1.0 2011-09-21 00:18:52 UTC 2018-05-28 18:33:54 UTC FDB022739 1,1-Dimethylbiguanide 1,1-Dimethylbiguanide or Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. [HMDB] 1,1-Dimethyl biguanide Diabefagos Diabex Diaformin Dianben Dimethylbiguanide DMBG Fortamet Glucophage Glumetza Meguan Metformin Metiguanide N,N-Dimethylbiguanide N1,N1-Dimethylbiguanide Obimet Riomet C4H11N5 129.1636 129.101445377 1-carbamimidamido-N,N-dimethylmethanimidamide metformin 1115-70-4 CN(C)C(=N)NC(N)=N InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) XZWYZXLIPXDOLR-UHFFFAOYSA-N belongs to the class of organic compounds known as biguanides. These are organic compounds containing two N-linked guanidines. Biguanides Organic compounds Organic nitrogen compounds Organonitrogen compounds Guanidines Aliphatic acyclic compounds Carboximidamides Hydrocarbon derivatives Imines Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Aliphatic acyclic compound Biguanide Carboximidamide Hydrocarbon derivative Imine Organic 1,3-dipolar compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound guanidines Solid logp -1.83 ALOGPS logs -1.97 ALOGPS solubility 1.38e+00 g/l ALOGPS logp -0.92 ChemAxon pka_strongest_basic 12.33 ChemAxon iupac 1-carbamimidamido-N,N-dimethylmethanimidamide ChemAxon average_mass 129.1636 ChemAxon mono_mass 129.101445377 ChemAxon smiles CN(C)C(=N)NC(N)=N ChemAxon formula C4H11N5 ChemAxon inchi InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) ChemAxon inchikey XZWYZXLIPXDOLR-UHFFFAOYSA-N ChemAxon polar_surface_area 88.99 ChemAxon refractivity 56.64 ChemAxon polarizability 13.43 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 5 ChemAxon donor_count 4 ChemAxon physiological_charge 2 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1740 Specdb::CMs 8532 Specdb::CMs 163652 Specdb::MsIr 1469 Specdb::MsIr 1470 Specdb::MsIr 1471 Specdb::NmrOneD 1800 Specdb::NmrOneD 148640 Specdb::NmrOneD 148641 Specdb::NmrOneD 148642 Specdb::NmrOneD 148643 Specdb::NmrOneD 148644 Specdb::NmrOneD 148645 Specdb::NmrOneD 148646 Specdb::NmrOneD 148647 Specdb::NmrOneD 148648 Specdb::NmrOneD 148649 Specdb::NmrOneD 148650 Specdb::NmrOneD 148651 Specdb::NmrOneD 148652 Specdb::NmrOneD 148653 Specdb::NmrOneD 148654 Specdb::NmrOneD 148655 Specdb::NmrOneD 148656 Specdb::NmrOneD 148657 Specdb::NmrOneD 148658 Specdb::NmrOneD 148659 Specdb::MsMs 1843 Specdb::MsMs 1844 Specdb::MsMs 1845 Specdb::MsMs 5607 Specdb::MsMs 5608 Specdb::MsMs 5609 Specdb::MsMs 5610 Specdb::MsMs 5611 Specdb::MsMs 260292 Specdb::MsMs 260293 Specdb::MsMs 260294 Specdb::MsMs 280227 Specdb::MsMs 280228 Specdb::MsMs 280229 Specdb::MsMs 440938 Specdb::MsMs 440939 Specdb::MsMs 440940 Specdb::MsMs 442407 Specdb::MsMs 442408 Specdb::MsMs 442409 Specdb::MsMs 442410 Specdb::MsMs 442411 Specdb::MsMs 442412 Specdb::MsMs 442413 Specdb::MsMs 442414 HMDB01921 #<Reference:0x000055ce302c7848> #<Reference:0x000055ce302c7690> #<Reference:0x000055ce302c74d8> #<Reference:0x000055ce302c7320> #<Reference:0x000055ce302c7168> #<Reference:0x000055ce302c6f88> #<Reference:0x000055ce302c6d30> #<Reference:0x000055ce302c6b78> #<Reference:0x000055ce302c6998> #<Reference:0x000055ce302c6768> #<Reference:0x000055ce302c6218> #<Reference:0x000055ce302c5e80> #<Reference:0x000055ce302c5cc8> #<Reference:0x000055ce302c5b10> #<Reference:0x000055ce302c5958> #<Reference:0x000055ce302c57a0> #<Reference:0x000055ce302c55e8> #<Reference:0x000055ce302c53e0> #<Reference:0x000055ce302c5228> #<Reference:0x000055ce302c5070> bitter