1.0 2011-09-21 00:18:53 UTC 2015-10-09 22:31:18 UTC FDB022740 Clotrimazole Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. -- Pubchem; There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs.; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. -- Wikipedia; An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.; Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. -- Wikipedia; Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch. [HMDB] (Chlorotrityl)imidazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(a-(2-Chlorophenyl)benzhydryl)imidazole 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole 1-(O-chloro-a,a-Diphenylbenzyl)imidazole 1-(O-chloro-alpha,alpha-Diphenylbenzyl)imidazole 1-(O-chloro-α,α-diphenylbenzyl)imidazole 1-(o-Chlorotrityl)imidazole 1-(α-(2-chlorophenyl)benzhydryl)imidazole Canesten Canesten 1-Day Cream Combi-Pak Canesten 1-Day Therapy Canesten 3-Day Therapy Canesten 6-Day Therapy Canesten Combi-Pak 1-Day Therapy Canesten Combi-Pak 3-Day Therapy Canesten Cream Canesten Solution Canestine Chlotrimazole Clotrimaderm Clotrimaderm Cream Clotrimazol Clotrimazole Clotrimazolum Desamix F Empecid Fem Care FemCare Gyne lotrimin Gyne-lotrimin Gyne-Lotrimin 3 Gyne-Lotrimin 3 Combination Pack Gyne-Lotrimin Combination Pack Gyne-Lotrimin3 Gyne-Lotrimin3 Combination Pack Gynix Lopac-C-6019 Lotrimax Lotrimin Lotrimin AF Lotrimin AF Cream Lotrimin AF Jock-Itch Cream Lotrimin AF Lotion Lotrimin AF Solution Lotrimin Cream Lotrimin Lotion Lotrimin Solution Lotrisone Mono-baycuten Monobaycuten Mycelax Mycelex Mycelex 7 Mycelex Cream Mycelex G Mycelex OTC Mycelex Solution Mycelex Troches Mycelex Twin Pack Mycelex-7 Mycelex-7 Combination Pack Mycelex-G Mycelex: MycosporinRimazole Myclo Cream Myclo Solution Myclo Spray Solution Myclo-Gyne Mycosporin Mykosporin Neo-Zol Cream Otomax Pedisafe Prestwick_120 Rimazole Tibatin Trimysten Trivagizole 3 Veltrim C22H17ClN2 344.837 344.108026261 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole clotrimazole 23593-75-1 ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1 InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H VNFPBHJOKIVQEB-UHFFFAOYSA-N belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety. Triphenyl compounds Organic compounds Benzenoids Triphenyl compounds Aromatic heteromonocyclic compounds Aryl chlorides Azacyclic compounds Chlorobenzenes Heteroaromatic compounds Hydrocarbon derivatives N-substituted imidazoles Organochlorides Organonitrogen compounds Organopnictogen compounds Aromatic heteromonocyclic compound Aryl chloride Aryl halide Azacycle Azole Chlorobenzene Halobenzene Heteroaromatic compound Hydrocarbon derivative Imidazole Monocyclic benzene moiety N-substituted imidazole Organic nitrogen compound Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Triphenyl compound a small molecule conazole antifungal drug imidazole antifungal drug imidazoles monochlorobenzenes Solid logp 5.48 ALOGPS logs -5.37 ALOGPS solubility 1.47e-03 g/l ALOGPS logp 5.84 ChemAxon pka_strongest_basic 6.62 ChemAxon iupac 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole ChemAxon average_mass 344.837 ChemAxon mono_mass 344.108026261 ChemAxon smiles ClC1=CC=CC=C1C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1 ChemAxon formula C22H17ClN2 ChemAxon inchi InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H ChemAxon inchikey VNFPBHJOKIVQEB-UHFFFAOYSA-N ChemAxon polar_surface_area 17.82 ChemAxon refractivity 103.76 ChemAxon polarizability 36.25 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 1109 Specdb::NmrOneD 1801 Specdb::CMs 7276 Specdb::CMs 164903 Specdb::NmrTwoD 1741 Specdb::MsMs 1846 Specdb::MsMs 1847 Specdb::MsMs 1848 Specdb::MsMs 252693 Specdb::MsMs 252694 Specdb::MsMs 252695 Specdb::MsMs 272634 Specdb::MsMs 272635 Specdb::MsMs 272636 Specdb::MsMs 442132 Specdb::MsMs 442133 Specdb::MsMs 442134 Specdb::MsMs 442135 Specdb::MsMs 450685 Specdb::MsMs 451125 Specdb::MsMs 451308 Specdb::MsMs 452374 Specdb::MsMs 2226285 Specdb::MsMs 2228404 Specdb::MsMs 2228646 Specdb::MsMs 2230823 Specdb::MsMs 2233355 Specdb::MsMs 2243338 Specdb::MsMs 2246703 Specdb::MsMs 2247596 HMDB01922 3764 CL6 #<Reference:0x000055ce309d38a8> #<Reference:0x000055ce309d36c8> #<Reference:0x000055ce309d3510> ATP synthase subunit b, mitochondrial P24539 ATP5F1 ATP synthase subunit epsilon-like protein, mitochondrial Q5VTU8 ATP5EP2 Disintegrin and metalloproteinase domain-containing protein 9 Q13443 ADAM9