1.0 2011-09-21 00:18:58 UTC 2015-10-09 22:31:18 UTC FDB022745 Hydrochlorothiazide A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. -- Pubchem Hydrochlorothiazide (Apo-Hydro, Aquazide H, Microzide, Oretic), sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug that acts by inhibiting the kidney's ability to retain water. This reduces the volume of the blood, decreasing peripheral vascular resistance. Chlorothiazide, a carbonic anhydrase inhibitor. --Wikipedia [HMDB] 3,4-Dihydrochlorothiazide Acuretic Aldactazide Aldoril Apresazide Aquarills Aquarius Bremil Caplaril Capozide Chlorosulthiadil Chlorothiazide Chlorsulfonamidodihydrobenzothiadiazine dioxide Chlorzide Cidrex Dichlorosal Dichlotiazid Dichlotride Diclotride Dihydrochlorothiazid Dihydrochlorothiazide Dihydrochlorothiazidum Dihydrochlorurit Dihydrochlorurite Dihydroxychlorothiazidum Direma Disalunil Diuril Drenol Dyazide Esidrex Esidrix Esimil Fluvin HCTZ HCZ Hidril Hidrochlortiazid Hidroclorotiazida Hidroronol Hidrotiazida Hydril Hydro-Aquil Hydro-D Hydro-Diuril Hydrochloro Thiazide Hydrochlorothiazid Hydrochlorothiazide Hydrochlorothiazide Intensol Hydrochlorothiazidum Hydrochlorthiazide Hydrodiuretic Hydrodiuril Hydropres Hydrosaluric Hydrothide Hydrozide Hypothiazid Hypothiazide Hyzaar Idrotiazide Inderide Ivaugan Jen-Diril Lopressor HCT Lotensin HCT Maschitt Maxzide Megadiuril Microzide Moduretic Nefrix Neo-codema Neoflumen Newtolide Oretic Panurin Prinzide Ro-hydrazide Ser-Ap-Es Servithiazid Thiaretic Thiuretic Thlaretic Timolide Unipres Urodiazin Vaseretic Vetidrex Ziac Zide C7H8ClN3O4S2 297.739 296.964474846 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide 58-93-5 NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1 InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13) JZUFKLXOESDKRF-UHFFFAOYSA-N belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position. 1,2,4-benzothiadiazine-1,1-dioxides Organic compounds Organoheterocyclic compounds Thiadiazines Benzothiadiazines Aromatic heteropolycyclic compounds Aminosulfonyl compounds Aryl chlorides Azacyclic compounds Benzenoids Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds Organosulfonamides Secondary alkylarylamines 1,2,4-benzothiadiazine-1,1-dioxide Amine Aminosulfonyl compound Aromatic heteropolycyclic compound Aryl chloride Aryl halide Azacycle Benzenoid Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organochloride Organohalogen compound Organonitrogen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Secondary aliphatic/aromatic amine Secondary amine Sulfonyl benzothiadiazine organochlorine compound sulfonamide Solid logp -0.16 ALOGPS logs -2.12 ALOGPS solubility 2.24e+00 g/l ALOGPS logp -0.58 ChemAxon pka_strongest_acidic 9.09 ChemAxon pka_strongest_basic -2.7 ChemAxon iupac 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide ChemAxon average_mass 297.739 ChemAxon mono_mass 296.964474846 ChemAxon smiles NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1 ChemAxon formula C7H8ClN3O4S2 ChemAxon inchi InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13) ChemAxon inchikey JZUFKLXOESDKRF-UHFFFAOYSA-N ChemAxon polar_surface_area 118.36 ChemAxon refractivity 63.11 ChemAxon polarizability 25.35 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 1807 Specdb::NmrOneD 2503 Specdb::NmrOneD 3200 Specdb::CMs 7529 Specdb::CMs 132612 Specdb::CMs 140346 Specdb::EiMs 450 Specdb::NmrTwoD 1747 Specdb::MsMs 1863 Specdb::MsMs 1864 Specdb::MsMs 1865 Specdb::MsMs 254301 Specdb::MsMs 254302 Specdb::MsMs 254303 Specdb::MsMs 274242 Specdb::MsMs 274243 Specdb::MsMs 274244 Specdb::MsMs 374502 Specdb::MsMs 435918 Specdb::MsMs 435919 Specdb::MsMs 435920 Specdb::MsMs 435921 Specdb::MsMs 435922 Specdb::MsMs 435923 Specdb::MsMs 435924 Specdb::MsMs 435925 Specdb::MsMs 435926 Specdb::MsMs 435927 Specdb::MsMs 435928 Specdb::MsMs 435929 Specdb::MsMs 435930 Specdb::MsMs 435931 Specdb::MsMs 436908 HMDB01928 HCZ #<Reference:0x000055ce304c3638> #<Reference:0x000055ce304c3480> #<Reference:0x000055ce304c3278> #<Reference:0x000055ce304c3098> #<Reference:0x000055ce304c2eb8> #<Reference:0x000055ce304c2d00> #<Reference:0x000055ce304c2af8> #<Reference:0x000055ce304c2940> #<Reference:0x000055ce304c2788> #<Reference:0x000055ce304c2558> #<Reference:0x000055ce304c2378> #<Reference:0x000055ce304c21c0> #<Reference:0x000055ce304c2008> #<Reference:0x000055ce304c1e50> #<Reference:0x000055ce304c1c98>