1.0 2011-09-21 00:18:59 UTC 2025-11-19 02:42:25 UTC FDB022746 Levofloxacin Levofloxacin is a synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin is marketed by Ortho-McNeil under the trade name Levaquin. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin. -- Wikipedia [HMDB] (-)-Ofloxacin (3S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate (3S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylate (S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylate (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid (S)-Ofloxacin Floxin L-Ofloxacin Levofloxacin Levofloxacin hydrate Levofloxacine Levofloxacino Levofloxacinum Ofloxacin Ofloxacin S-(-)-form Quixin C18H20FN3O4 361.3675 361.143784348 (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid 100986-85-4 C[C@H]1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1 GSDSWSVVBLHKDQ-JTQLQIEISA-N belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions. Quinoline carboxylic acids Organic compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids Aromatic heteropolycyclic compounds Alkyl aryl ethers Amino acids Aminoquinolines and derivatives Aryl fluorides Azacyclic compounds Benzenoids Benzoxazines Carboxylic acids Dialkylarylamines Fluoroquinolones Haloquinolines Heteroaromatic compounds Hydrocarbon derivatives Hydroquinolines Hydroquinolones Monocarboxylic acids and derivatives N-arylpiperazines N-methylpiperazines Organic oxides Organofluorides Organopnictogen compounds Oxacyclic compounds Pyridinecarboxylic acids Trialkylamines Vinylogous amides 1,4-diazinane Alkyl aryl ether Amine Amino acid Amino acid or derivatives Aminoquinoline Aromatic heteropolycyclic compound Aryl fluoride Aryl halide Azacycle Benzenoid Benzoxazine Carboxylic acid Carboxylic acid derivative Dialkylarylamine Dihydroquinoline Dihydroquinolone Ether Fluoroquinolone Haloquinoline Heteroaromatic compound Hydrocarbon derivative Monocarboxylic acid or derivatives N-alkylpiperazine N-arylpiperazine N-methylpiperazine Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Piperazine Pyridine Pyridine carboxylic acid Pyridine carboxylic acid or derivatives Quinoline-3-carboxylic acid Tertiary aliphatic amine Tertiary aliphatic/aromatic amine Tertiary amine Vinylogous amide fluoroquinolone antibiotic ofloxacin quinolone antibiotic Solid logp -0.02 ALOGPS logs -2.40 ALOGPS solubility 1.44e+00 g/l ALOGPS logp 0.65 ChemAxon pka_strongest_acidic 5.45 ChemAxon pka_strongest_basic 6.2 ChemAxon iupac (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid ChemAxon average_mass 361.3675 ChemAxon mono_mass 361.143784348 ChemAxon smiles C[C@H]1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(F)=C2N1CCN(C)CC1 ChemAxon formula C18H20FN3O4 ChemAxon inchi InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1 ChemAxon inchikey GSDSWSVVBLHKDQ-JTQLQIEISA-N ChemAxon polar_surface_area 73.32 ChemAxon refractivity 94.94 ChemAxon polarizability 36.69 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 7 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1748 Specdb::CMs 13175 Specdb::CMs 38188 Specdb::CMs 168879 Specdb::NmrOneD 1808 Specdb::NmrOneD 148660 Specdb::NmrOneD 148661 Specdb::NmrOneD 148662 Specdb::NmrOneD 148663 Specdb::NmrOneD 148664 Specdb::NmrOneD 148665 Specdb::NmrOneD 148666 Specdb::NmrOneD 148667 Specdb::NmrOneD 148668 Specdb::NmrOneD 148669 Specdb::NmrOneD 148670 Specdb::NmrOneD 148671 Specdb::NmrOneD 148672 Specdb::NmrOneD 148673 Specdb::NmrOneD 148674 Specdb::NmrOneD 148675 Specdb::NmrOneD 148676 Specdb::NmrOneD 148677 Specdb::NmrOneD 148678 Specdb::NmrOneD 148679 Specdb::MsMs 1866 Specdb::MsMs 1867 Specdb::MsMs 1868 Specdb::MsMs 250026 Specdb::MsMs 250027 Specdb::MsMs 250028 Specdb::MsMs 269964 Specdb::MsMs 269965 Specdb::MsMs 269966 Specdb::MsMs 443993 Specdb::MsMs 443994 Specdb::MsMs 443995 Specdb::MsMs 443996 Specdb::MsMs 443997 Specdb::MsMs 451030 Specdb::MsMs 451309 Specdb::MsMs 2237425 Specdb::MsMs 2239510 Specdb::MsMs 2248476 Specdb::MsMs 2249923 Specdb::MsMs 2757534 Specdb::MsMs 2757535 Specdb::MsMs 2757536 Specdb::MsMs 2947929 Specdb::MsMs 2947930 HMDB01929 LFX #<Reference:0x000055ce323bdb38> #<Reference:0x000055ce323bd958> #<Reference:0x000055ce323bd7a0> #<Reference:0x000055ce323bd5e8> bitter DNA topoisomerase 2-alpha P11388 TOP2A