1.0 2011-09-21 00:19:05 UTC 2015-10-09 22:31:20 UTC FDB022754 Medroxyprogesterone A synthetic progesterone (steroid hormone) involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. -- Wikipedia Progesterone's reproductive function serves to convert the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. Normal menstrual bleeding is a progesterone withdrawal bleeding. -- Wikipedia During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus. -- Wikipedia A synthetic progestational hormone used in veterinary practice as an estrus regulator. -- Pubchem [HMDB] 17-Hydroxy-6a-methyl-pregn-4-ene-3,20-dione 17-Hydroxy-6a-methylprogesterone 17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione 17-Hydroxy-6alpha-methylprogesterone 17-Hydroxy-6α-methyl-pregn-4-ene-3,20-dione 17-Hydroxy-6α-methylprogesterone 17a-Hydroxy-6a-methylprogesterone 17alpha-Hydroxy-6alpha-methylprogesterone 17α-hydroxy-6α-methylprogesterone 6a-Methyl-17a-hydroxyprogesterone 6a-Methyl-4-pregnen-17a-ol-3,20-dione 6alpha-Methyl-17alpha-hydroxyprogesterone 6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione 6α-methyl-17α-hydroxyprogesterone 6α-methyl-4-pregnen-17α-ol-3,20-dione Cycrin Depo-Provera Depo-Subq Provera 104 Farlutal Medrossiprogesterone Medroxiprogesterona Medroxiprogesteronum Medroxyprogesteron Medroxyprogesterone Acetate Medroxyprogesteronum Provera C22H32O3 344.4877 344.23514489 (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one 520-85-4 [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1 FRQMUZJSZHZSGN-HBNHAYAOSA-N belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. Gluco/mineralocorticoids, progestogins and derivatives Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Pregnane steroids Aliphatic homopolycyclic compounds 17-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Organic oxides Tertiary alcohols 17-hydroxysteroid 20-oxosteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Hydroxysteroid Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Progestogin-skeleton Tertiary alcohol 17alpha-hydroxy steroid 20-oxo steroid 3-oxo Delta(4)-steroid C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives Solid logp 3.52 ALOGPS logs -4.35 ALOGPS solubility 1.54e-02 g/l ALOGPS logp 3.69 ChemAxon pka_strongest_acidic 12.7 ChemAxon pka_strongest_basic -3.8 ChemAxon iupac (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one ChemAxon average_mass 344.4877 ChemAxon mono_mass 344.23514489 ChemAxon smiles [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C ChemAxon formula C22H32O3 ChemAxon inchi InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1 ChemAxon inchikey FRQMUZJSZHZSGN-HBNHAYAOSA-N ChemAxon polar_surface_area 54.37 ChemAxon refractivity 98.65 ChemAxon polarizability 40.07 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 3 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 1817 Specdb::NmrTwoD 1757 Specdb::CMs 20439 Specdb::CMs 38195 Specdb::CMs 135405 Specdb::CMs 143139 Specdb::MsMs 1893 Specdb::MsMs 1894 Specdb::MsMs 1895 Specdb::MsMs 311515 Specdb::MsMs 311516 Specdb::MsMs 311517 Specdb::MsMs 356533 Specdb::MsMs 356534 Specdb::MsMs 356535 Specdb::MsMs 374414 Specdb::MsMs 451052 Specdb::MsMs 451334 Specdb::MsMs 2227298 Specdb::MsMs 2227401 Specdb::MsMs 2229734 Specdb::MsMs 2229771 Specdb::MsMs 2232015 Specdb::MsMs 2232157 Specdb::MsMs 2233166 Specdb::MsMs 2234371 Specdb::MsMs 2234596 Specdb::MsMs 2244042 Specdb::MsMs 2246066 Specdb::MsMs 2255173 Specdb::MsMs 2255383 HMDB01939 Estrogen receptor P03372 ESR1 Progesterone receptor P06401 PGR