1.0 2011-09-21 00:22:12 UTC 2015-07-21 06:57:26 UTC FDB022947 N-Acetylcadaverine N-Acetylcadaverine is the acetylated form of the polyamine cadaverine. Cadaverine is produced by the breakdown of amino acids in living and dead organisms and is toxic in large doses. Cadaverine is largely responsible for the foul odor of putrefying flesh, but also contributes to the odor of such processes as bad breath and bacterial vaginosis. Cadaverine is also found in semen. Polyamines (and their acetylated forms) are known to be closely related with cell growth, cell proliferation, and synthesis of proteins and nucleic acids. Their concentrations are adjusted either by regulating the activity levels of the biosynthetic and catabolic reactions or by controlling the net direction of polyamine acetylation-deacetylation. In Alzheimer's disease (AD), the neurotoxic amyloid β-peptide is known to up-regulate polyamine metabolism by increasing ornithine decarboxylase activity and polyamine uptake by initiating free radical damage. Because of these findings, polyamines have been considered to play an important role in response to neurodegenerative conditions. Altered levels of polyamines have been found in tissue, hair and body fluids of patients with neuromuscular diseases and neurodegenerative conditions. (PMID: 17723614) [HMDB] Acetylcadaverine Monoacetyl cadaverine N-(5-aminopentyl)acetamide C7H16N2O 144.2147 144.126263144 N-(5-aminopentyl)acetamide N-acetylcadaverine 32343-73-0 CC(=O)NCCCCCN InChI=1S/C7H16N2O/c1-7(10)9-6-4-2-3-5-8/h2-6,8H2,1H3,(H,9,10) RMOIHHAKNOFHOE-UHFFFAOYSA-N belongs to the class of organic compounds known as acetamides. These are organic compounds with the general formula RNHC(=O)CH3, where R= organyl group. Acetamides Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Aliphatic acyclic compounds Amino acids and derivatives Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organopnictogen compounds Secondary carboxylic acid amides Acetamide Aliphatic acyclic compound Amine Amino acid or derivatives Carbonyl group Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary aliphatic amine Primary amine Secondary carboxylic acid amide Solid logp -0.40 ALOGPS logs -0.78 ALOGPS solubility 2.37e+01 g/l ALOGPS logp -0.58 ChemAxon pka_strongest_acidic 16.53 ChemAxon pka_strongest_basic 10.21 ChemAxon iupac N-(5-aminopentyl)acetamide ChemAxon average_mass 144.2147 ChemAxon mono_mass 144.126263144 ChemAxon smiles CC(=O)NCCCCCN ChemAxon formula C7H16N2O ChemAxon inchi InChI=1S/C7H16N2O/c1-7(10)9-6-4-2-3-5-8/h2-6,8H2,1H3,(H,9,10) ChemAxon inchikey RMOIHHAKNOFHOE-UHFFFAOYSA-N ChemAxon polar_surface_area 55.12 ChemAxon refractivity 41.42 ChemAxon polarizability 17.36 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 2 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 11182 Specdb::CMs 148905 Specdb::MsIr 1719 Specdb::MsIr 1720 Specdb::MsIr 1721 Specdb::MsMs 100776 Specdb::MsMs 100777 Specdb::MsMs 100778 Specdb::MsMs 166218 Specdb::MsMs 166219 Specdb::MsMs 166220 Specdb::MsMs 2840703 Specdb::MsMs 2840704 Specdb::MsMs 2840705 Specdb::MsMs 2865081 Specdb::MsMs 2865082 Specdb::MsMs 2865083 Specdb::NmrOneD 115978 Specdb::NmrOneD 115979 Specdb::NmrOneD 115980 Specdb::NmrOneD 115981 Specdb::NmrOneD 115982 Specdb::NmrOneD 115983 Specdb::NmrOneD 115984 Specdb::NmrOneD 115985 Specdb::NmrOneD 115986 Specdb::NmrOneD 115987 Specdb::NmrOneD 115988 Specdb::NmrOneD 115989 Specdb::NmrOneD 115990 Specdb::NmrOneD 115991 Specdb::NmrOneD 115992 Specdb::NmrOneD 115993 Specdb::NmrOneD 115994 Specdb::NmrOneD 115995 Specdb::NmrOneD 115996 Specdb::NmrOneD 115997 HMDB02284 #<Reference:0x000055ce31f00618> #<Reference:0x000055ce31f00460> #<Reference:0x000055ce31f002a8> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823