1.0 2011-09-21 00:24:15 UTC 2015-07-21 06:57:30 UTC FDB023072 Testosterone sulfate Testerone is a predominantly male hormone, though females do produce certain amounts of it. The primary female hormone is estrogen and males also produce certain amounts of this hormone. testosterone causes the appearance of male traits (i.e deepening voice, pubic and facial hairs, muscular build, etc.) The keto group on C-17 is reduced to an alcohol to yield testosterone. testosterone is a steroid hormone from the androgen group. testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. On average, the adult male body produces about twenty times the amount of testosterone that an adult female's body does. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-alpha -dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha-reductase(5-alpha-reduktas). DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. It is important to note that if there is a too low amount of 5-alpha-reductase(5-alfa-reduktas), the body (of a human) will -continue- growing into a female with testicles. [HMDB] 17-O-Sulfotestosterone 17beta-(Sulfooxy)androst-4-en-3-one Testosterone 17-sulfate Testosterone 17-sulphate Testosterone 17b-sulfate Testosterone 17b-sulphate Testosterone hydrogen sulfate Testosterone hydrogen sulphate Testosterone monosulfate Testosterone monosulphate Testosterone sulfate Testosterone sulfic acid Testosterone sulphate Testosterone-17-sulfate Testosterone-17-sulphate Testosterone-17b-sulfate Testosterone-17b-sulfuric acid Testosterone-17b-sulphate Testosterone-17b-sulphuric acid Testosterone-17beta-sulfate Testosterone-17beta-sulfuric acid Testosterone-17beta-sulphate Testosterone-17beta-sulphuric acid Testosterone-17β-sulfate Testosterone-17β-sulfuric acid Testosterone-17β-sulphate Testosterone-17β-sulphuric acid C19H28O5S 368.488 368.165744696 [(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl]oxidanesulfonic acid testosterone sulfate 651-45-6 [H][C@@]12CC[C@H](OS(O)(=O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1 WAQBISPOEAOCOG-DYKIIFRCSA-N belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton. Sulfated steroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Sulfated steroids Aliphatic homopolycyclic compounds 3-oxo delta-4-steroids Alkyl sulfates Androgens and derivatives Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Organic oxides Sulfuric acid monoesters 3-oxo-delta-4-steroid 3-oxosteroid Aliphatic homopolycyclic compound Alkyl sulfate Androgen-skeleton Androstane-skeleton Carbonyl group Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organic sulfuric acid or derivatives Organooxygen compound Oxosteroid Sulfate-ester Sulfated steroid skeleton Sulfuric acid ester Sulfuric acid monoester 3-oxo steroid Sulfates androstanoid steroid sulfate Solid logp 0.13 ALOGPS logs -4.72 ALOGPS solubility 7.02e-03 g/l ALOGPS logp 3.42 ChemAxon pka_strongest_acidic -1.3 ChemAxon pka_strongest_basic -4.8 ChemAxon iupac [(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl]oxidanesulfonic acid ChemAxon average_mass 368.488 ChemAxon mono_mass 368.165744696 ChemAxon smiles [H][C@@]12CC[C@H](OS(O)(=O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C19H28O5S ChemAxon inchi InChI=1S/C19H28O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h11,14-17H,3-10H2,1-2H3,(H,21,22,23)/t14-,15-,16-,17-,18-,19-/m0/s1 ChemAxon inchikey WAQBISPOEAOCOG-DYKIIFRCSA-N ChemAxon polar_surface_area 80.67 ChemAxon refractivity 94.42 ChemAxon polarizability 39.59 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 13479 Specdb::CMs 151164 Specdb::MsMs 50553 Specdb::MsMs 50554 Specdb::MsMs 50555 Specdb::MsMs 147102 Specdb::MsMs 147103 Specdb::MsMs 147104 Specdb::MsMs 2335114 Specdb::MsMs 2335115 Specdb::MsMs 2335116 Specdb::MsMs 2626718 Specdb::MsMs 2626719 Specdb::MsMs 2626720 HMDB02833 #<Reference:0x000055ce3354fd38> #<Reference:0x000055ce3354fa90> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 3-oxo-5-alpha-steroid 4-dehydrogenase 1 P18405 SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 2 P31213 SRD5A2 3-oxo-5-beta-steroid 4-dehydrogenase P51857 AKR1D1 Cytochrome P450 2D6 Q6NWU0 CYP2D6 Cytochrome P450, family 1, subfamily A, polypeptide 1 A0N0X8 CYP1A1 Testosterone 17-beta-dehydrogenase 3 P37058 HSD17B3 UDP-glucuronosyltransferase 1-1 P22309 UGT1A1 UDP-glucuronosyltransferase 1-3 P35503 UGT1A3 UDP-glucuronosyltransferase 1-4 P22310 UGT1A4 UDP-glucuronosyltransferase 1-5 P35504 UGT1A5 UDP-glucuronosyltransferase 1-6 P19224 UGT1A6 UDP-glucuronosyltransferase 1-9 O60656 UGT1A9 UDP-glucuronosyltransferase 2A1 Q9Y4X1 UGT2A1 UDP-glucuronosyltransferase 2A3 Q6UWM9 UGT2A3 UDP-glucuronosyltransferase 2B11 O75310 UGT2B11 UDP-glucuronosyltransferase 2B15 P54855 UGT2B15 UDP-glucuronosyltransferase 2B17 O75795 UGT2B17 UDP-glucuronosyltransferase 2B28 Q9BY64 UGT2B28 UDP-glucuronosyltransferase 2B4 P06133 UGT2B4 UDP-glucuronosyltransferase 2B7 P16662 UGT2B7