1.0 2011-09-21 00:24:54 UTC 2025-11-19 02:43:15 UTC FDB023115 N-Methylnicotinamide N-methylnicotinamide is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-methylnicotinamide indicates niacin deficiency. (PMID: 16207585). In patients with liver cirrhosis nicotinamide methylation is increased leading to a rise in urinary N-methylnicotinamide. The hyperfunction of this methylating pathway might play a protective role against the toxic effect of intracellular accumulation of nicotinamide deriving from the catabolic state of cirrhosis. N-methylnicotinamide is known to inhibit choline transport and reduce choline clearance out of the brain. [HMDB] 3-(Methylcarbamoyl)pyridine 3-(N-Methylcarbamoyl)pyridine N -Methyl nicotineamide N-Methyl nicotineamide N-Methyl-3-pyridinecarboxamide N-methylnicotinamide N-Methylpyridine-3-carboxamide Nicotinate methylamide Nicotinic acid methylamide C7H8N2O 136.1512 136.063662888 N-methylpyridine-3-carboxamide N'methylnicotinamide 114-33-0 CNC(=O)C1=CN=CC=C1 InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10) ZYVXHFWBYUDDBM-UHFFFAOYSA-N belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group. Nicotinamides Organic compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Aromatic heteromonocyclic compounds Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Secondary carboxylic acid amides Aromatic heteromonocyclic compound Azacycle Carboxamide group Carboxylic acid derivative Heteroaromatic compound Hydrocarbon derivative Nicotinamide Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary carboxylic acid amide pyridinecarboxamide Solid logp 0.65 ALOGPS logs -1.70 ALOGPS solubility 2.70e+00 g/l ALOGPS logp -0.17 ChemAxon pka_strongest_acidic 13.75 ChemAxon pka_strongest_basic 3.62 ChemAxon iupac N-methylpyridine-3-carboxamide ChemAxon average_mass 136.1512 ChemAxon mono_mass 136.063662888 ChemAxon smiles CNC(=O)C1=CN=CC=C1 ChemAxon formula C7H8N2O ChemAxon inchi InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10) ChemAxon inchikey ZYVXHFWBYUDDBM-UHFFFAOYSA-N ChemAxon polar_surface_area 41.99 ChemAxon refractivity 37.88 ChemAxon polarizability 13.87 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1865 Specdb::CMs 13108 Specdb::CMs 135385 Specdb::CMs 143119 Specdb::NmrOneD 1930 Specdb::NmrOneD 129338 Specdb::NmrOneD 129339 Specdb::NmrOneD 129340 Specdb::NmrOneD 129341 Specdb::NmrOneD 129342 Specdb::NmrOneD 129343 Specdb::NmrOneD 129344 Specdb::NmrOneD 129345 Specdb::NmrOneD 129346 Specdb::NmrOneD 129347 Specdb::NmrOneD 129348 Specdb::NmrOneD 129349 Specdb::NmrOneD 129350 Specdb::NmrOneD 129351 Specdb::NmrOneD 129352 Specdb::NmrOneD 129353 Specdb::NmrOneD 129354 Specdb::NmrOneD 129355 Specdb::NmrOneD 129356 Specdb::NmrOneD 129357 Specdb::NmrOneD 166319 Specdb::NmrOneD 166360 Specdb::MsMs 64467 Specdb::MsMs 64468 Specdb::MsMs 64469 Specdb::MsMs 121626 Specdb::MsMs 121627 Specdb::MsMs 121628 Specdb::MsMs 2236660 Specdb::MsMs 2236729 Specdb::MsMs 2238775 Specdb::MsMs 2238795 Specdb::MsMs 2240786 Specdb::MsMs 2240925 Specdb::MsMs 2242811 Specdb::MsMs 2243011 Specdb::MsMs 2247045 Specdb::MsMs 2744604 Specdb::MsMs 2744605 Specdb::MsMs 2744606 Specdb::MsMs 2936968 Specdb::MsMs 2936969 Specdb::MsMs 2936970 Specdb::MsIr 6 Specdb::MsIr 26 Specdb::MsIr 47 Specdb::MsIr 1886 Specdb::MsIr 1887 Specdb::MsIr 1888 HMDB03152 #<Reference:0x000055ce31e5e660> #<Reference:0x000055ce31e5e4a8> #<Reference:0x000055ce31e5e2f0> #<Reference:0x000055ce31e5e138> #<Reference:0x000055ce31e5df80> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823