1.02011-09-21 00:25:02 UTC2015-07-21 06:57:31 UTCFDB023124ThromboxaneThromboxane is a member of the family of lipids known as eicosanoids. It is produced in platelets by thromboxane synthetase, which is produced from the endoperoxides by the cyclooxygenase (COX) enzyme from arachidonic acid. -- Wikipedia; Thromboxane is a vasoconstrictor, potent hypertensive agent, and facilitates the clumping of platelets. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The widely-used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. -- Wikipedia
Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways. [HMDB]Thromboxane a2C20H40O296.531296.307915902(2R,3S)-3-heptyl-2-octyloxane(2R,3S)-3-heptyl-2-octyl-oxane66719-58-2CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCCInChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1RZWIIPASKMUIAC-VQTJNVASSA-N belongs to the class of organic compounds known as thromboxanes. These are eicosanoids structurally characterized by the presence of a 6-member ether containing ring.ThromboxanesOrganic compoundsLipids and lipid-like moleculesFatty AcylsEicosanoidsAliphatic heteromonocyclic compoundsDialkyl ethersHydrocarbon derivativesOxacyclic compoundsOxanesAliphatic heteromonocyclic compoundDialkyl etherEtherHydrocarbon derivativeOrganic oxygen compoundOrganoheterocyclic compoundOrganooxygen compoundOxacycleOxaneThromboxaneSolidlogp8.56logs-7.39solubility1.22e-05 g/llogp7.61pka_strongest_basic-4.1iupac(2R,3S)-3-heptyl-2-octyloxaneaverage_mass296.531mono_mass296.307915902smilesCCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCCformulaC20H40OinchiInChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1inchikeyRZWIIPASKMUIAC-VQTJNVASSA-Npolar_surface_area9.23refractivity93.78polarizability41.15rotatable_bond_count13acceptor_count1donor_count0physiological_charge0formal_charge0Specdb::CMs23404Specdb::CMs136235Specdb::CMs143969Specdb::MsMs317908Specdb::MsMs317909Specdb::MsMs317910Specdb::MsMs364516Specdb::MsMs364517Specdb::MsMs364518Specdb::MsMs2427103Specdb::MsMs2427104Specdb::MsMs2427105Specdb::MsMs2511999Specdb::MsMs2512000Specdb::MsMs2512001HMDB03208#<Reference:0x0000555674b781d8>#<Reference:0x0000555674b78020>#<Reference:0x0000555674b6be10>#<Reference:0x0000555674b6bc58>#<Reference:0x0000555674b6baa0>#<Reference:0x0000555674b6b8e8>#<Reference:0x0000555674b6b730>#<Reference:0x0000555674b6b578>#<Reference:0x0000555674b6b3c0>#<Reference:0x0000555674b6b208>#<Reference:0x0000555674b6b050>#<Reference:0x0000555674b6ae20>#<Reference:0x0000555674b6abc8>#<Reference:0x0000555674b6a9e8>#<Reference:0x0000555674b6a830>#<Reference:0x0000555674b6a650>#<Reference:0x0000555674b6a498>#<Reference:0x0000555674b6a2e0>#<Reference:0x0000555674b6a0b0>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823