1.0 2011-09-21 00:26:00 UTC 2015-07-21 06:57:35 UTC FDB023190 2'-Deoxyinosine triphosphate 2'-Deoxyinosine triphosphate (dITP) is a deoxyribonucleotide that may be generated from dATP by slow, non-enzymatic hydrolysis or by reduction of ITP. Normally, the cellular dITP concentration is very low. The inability to demonstrate the synthesis of dITP in cellular preparations has been attributed to the presence in the cytoplasm of an inosine triphosphatase pyrophosphatase (ITPase, EC 3.6.1.19), an enzyme that does not permit accumulation of these nucleotides. dITP can be incorporated into DNA by polymerases. The deoxyribonucleotide dITP behaves as a dGTP analogue and is incorporated opposite cytosine with about 50% efficiency. Both isolated nuclei and purified DNA polymerases rapidly incorporated dITP into DNA. In the presence of ATP, dITP is stabilized in extracts of nuclei. dITP exist in all cells and is potentially mutagenic, and the levels of these nucleotides are controlled by ITPase. The function of this ubiquitous protein family is proposed to be the elimination of minor potentially mutagenic or clastogenic purine nucleoside triphosphates from the cell. (PMID: 11278832) [HMDB] 2'-Deoxy-inosine 5'-(tetrahydrogen triate) 2'-deoxy-Inosine 5'-(tetrahydrogen triphosphate) 2'-Deoxyinosine 5'-triate 2'-Deoxyinosine 5'-triic acid 2'-Deoxyinosine-5'-triate 2'-Deoxyinosine-5'-triic acid 2'-Deoxyinosine-5'-triphosphate 2'-Ditp Deoxyinosine 5'-triate Deoxyinosine 5'-triic acid Deoxyinosine 5'-triphosphate Deoxyinosine triate Deoxyinosine triphosphate dITP C10H15N4O13P3 492.1664 491.984846122 {[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid [hydroxy({hydroxy[(2R,3S,5R)-3-hydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphoryl}oxy)phosphoryl]oxyphosphonic acid 16595-02-1 O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=NC2=C1NC=NC2=O InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 UFJPAQSLHAGEBL-RRKCRQDMSA-N belongs to the class of organic compounds known as purine 2'-deoxyribonucleoside triphosphates. These are purine nucleotides with triphosphate group linked to the ribose moiety lacking a hydroxyl group at position 2. Purine 2'-deoxyribonucleoside triphosphates Organic compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine deoxyribonucleotides Aromatic heteropolycyclic compounds 6-oxopurines Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Hypoxanthines Monoalkyl phosphates N-substituted imidazoles Organic oxides Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Pyrimidones Secondary alcohols Tetrahydrofurans Vinylogous amides 6-oxopurine Alcohol Alkyl phosphate Aromatic heteropolycyclic compound Azacycle Azole Heteroaromatic compound Hydrocarbon derivative Hypoxanthine Imidazole Imidazopyrimidine Monoalkyl phosphate N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Phosphoric acid ester Purine Purine 2'-deoxyribonucleoside triphosphate Pyrimidine Pyrimidone Secondary alcohol Tetrahydrofuran Vinylogous amide deoxyinosine phosphate purine 2'-deoxyribonucleoside 5'-triphosphate Solid logp -0.26 ALOGPS logs -1.99 ALOGPS solubility 5.04e+00 g/l ALOGPS logp -3.8 ChemAxon pka_strongest_acidic 0.89 ChemAxon pka_strongest_basic 2.85 ChemAxon iupac {[hydroxy({[hydroxy({[(2R,3S,5R)-3-hydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid ChemAxon average_mass 492.1664 ChemAxon mono_mass 491.984846122 ChemAxon smiles O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=NC2=C1NC=NC2=O ChemAxon formula C10H15N4O13P3 ChemAxon inchi InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 ChemAxon inchikey UFJPAQSLHAGEBL-RRKCRQDMSA-N ChemAxon polar_surface_area 248.56 ChemAxon refractivity 92.01 ChemAxon polarizability 36.03 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 13 ChemAxon donor_count 6 ChemAxon physiological_charge -4 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 19663 Specdb::CMs 38622 Specdb::CMs 132748 Specdb::CMs 140482 Specdb::NmrOneD 28162 Specdb::NmrOneD 28163 Specdb::NmrOneD 28164 Specdb::NmrOneD 28165 Specdb::NmrOneD 28166 Specdb::NmrOneD 28167 Specdb::NmrOneD 28168 Specdb::NmrOneD 28169 Specdb::NmrOneD 28170 Specdb::NmrOneD 28171 Specdb::NmrOneD 28172 Specdb::NmrOneD 28173 Specdb::NmrOneD 28174 Specdb::NmrOneD 28175 Specdb::NmrOneD 28176 Specdb::NmrOneD 28177 Specdb::NmrOneD 28178 Specdb::NmrOneD 28179 Specdb::NmrOneD 28180 Specdb::NmrOneD 28181 Specdb::MsMs 24401 Specdb::MsMs 24402 Specdb::MsMs 24403 Specdb::MsMs 30959 Specdb::MsMs 30960 Specdb::MsMs 30961 Specdb::MsMs 2316452 Specdb::MsMs 2316453 Specdb::MsMs 2316454 Specdb::MsMs 2621699 Specdb::MsMs 2621700 Specdb::MsMs 2621701 HMDB03537 #<Reference:0x000055ce31d7b068> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823