1.0 2011-09-21 00:27:17 UTC 2015-07-21 06:57:37 UTC FDB023274 19-Oxotestosterone 19-Oxotestosterone is catalyzed by Aromatase (EC 1.14.14.1),also called estrogen synthetase (a cytochrome P450 enzyme which catalyzes the formation of aromatic C18 estrogens from C19 androgens; it is symbolized CYP19) into oestrogens via sequential oxidations at the 19-methyl group. Biosynthesis of estrogens from C19 steroids is catalyzed by aromatase and its tissue-specific expression is determined at least in part by alternative use of tissue-specific promoters, which give rise to transcripts with unique 5-prime noncoding termini.(OMIM 107910) [HMDB] C19H28O2 288.4244 288.20893014 (1S,2R,10R,11R,14R,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (1S,2R,10R,11R,14R,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one 4075-13-2 [H][C@@]1(O)CC[C@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15+,16-,17+,18-,19-/m0/s1 MUMGGOZAMZWBJJ-WXJALIKYSA-N belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. Androgens and derivatives Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Androstane steroids Aliphatic homopolycyclic compounds 17-hydroxysteroids 3-oxo delta-4-steroids Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Organic oxides Secondary alcohols 17-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Androgen-skeleton Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Hydroxysteroid Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Secondary alcohol Solid logp 2.99 ALOGPS logs -3.94 ALOGPS solubility 3.33e-02 g/l ALOGPS logp 3.37 ChemAxon pka_strongest_acidic 19.09 ChemAxon pka_strongest_basic -0.88 ChemAxon iupac (1S,2R,10R,11R,14R,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one ChemAxon average_mass 288.4244 ChemAxon mono_mass 288.20893014 ChemAxon smiles [H][C@@]1(O)CC[C@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C ChemAxon formula C19H28O2 ChemAxon inchi InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15+,16-,17+,18-,19-/m0/s1 ChemAxon inchikey MUMGGOZAMZWBJJ-WXJALIKYSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 84.43 ChemAxon polarizability 33.84 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Androgen and Estrogen Metabolism SMP00068 map00150 HMDB03959 #<Reference:0x000055ce32548700> #<Reference:0x000055ce32548548> #<Reference:0x000055ce32548390> #<Reference:0x000055ce325481d8> #<Reference:0x000055ce32548020> #<Reference:0x000055ce32547e68> #<Reference:0x000055ce32547cb0> #<Reference:0x000055ce32547af8> #<Reference:0x000055ce32547940> #<Reference:0x000055ce32547788> #<Reference:0x000055ce325475d0> #<Reference:0x000055ce32547418> #<Reference:0x000055ce32547260> #<Reference:0x000055ce325470a8> #<Reference:0x000055ce32546ef0> #<Reference:0x000055ce32546d38> #<Reference:0x000055ce32546b80> #<Reference:0x000055ce325469c8> #<Reference:0x000055ce32546810> #<Reference:0x000055ce32546658> 3-oxo-5-beta-steroid 4-dehydrogenase P51857 AKR1D1 Cytochrome P450 2D6 Q6NWU0 CYP2D6 Cytochrome P450, family 1, subfamily A, polypeptide 1 A0N0X8 CYP1A1