1.0 2011-09-21 00:29:00 UTC 2015-07-21 06:57:39 UTC FDB023378 1D-Myo-inositol 1,4,5,6-tetrakisphosphate 1D-Myo-inositol 1,4,5,6-tetrakisphosphate has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains, and finally, it may contribute to transcriptional regulation. Inositol phosphates comprise a large family of intracellular signals which play many important roles in cell biology. These biological actions can be quite specific to one particular inositol phosphate. 1D-myo-Inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) is phosphorylated by inositolphosphate-multikinase (IPMK; this enzyme has the capacity to regulate the cellular levels of Ins(1,4,5,6)P4 in mammalian cells. (PMID: 16376887, 10720331, 8809047, 9405634) [HMDB] 1D-myo-Inositol 1,4,5,6-tetrakisate 1D-myo-Inositol 1,4,5,6-tetrakisic acid 1D-myo-Inositol 1,4,5,6-tetrakisphosphic acid D-myo-Inositol 1,4,5,6-tetrakisate D-myo-Inositol 1,4,5,6-tetrakisic acid D-myo-Inositol 1,4,5,6-tetrakisphosphate Inositol 1,4,5,6-tetrakisate Inositol 1,4,5,6-tetrakisic acid Inositol 1,4,5,6-tetrakisphosphate C6H16O18P4 500.0755 499.928709756 {[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid [(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid 121010-58-0 O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1 MRVYFOANPDTYBY-YORTWTKJSA-N belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. Inositol phosphates Organic compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Aliphatic homomonocyclic compounds 1,2-diols Cyclohexanols Hydrocarbon derivatives Monoalkyl phosphates Organic oxides 1,2-diol Aliphatic homomonocyclic compound Alkyl phosphate Cyclohexanol Hydrocarbon derivative Inositol phosphate Monoalkyl phosphate Organic oxide Organic phosphoric acid derivative Phosphoric acid ester Secondary alcohol myo-inositol tetrakisphosphate Solid logp -0.45 ALOGPS logs -1.64 ALOGPS solubility 1.15e+01 g/l ALOGPS logp -4.3 ChemAxon pka_strongest_acidic 0.24 ChemAxon iupac {[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid ChemAxon average_mass 500.0755 ChemAxon mono_mass 499.928709756 ChemAxon smiles O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O ChemAxon formula C6H16O18P4 ChemAxon inchi InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1 ChemAxon inchikey MRVYFOANPDTYBY-YORTWTKJSA-N ChemAxon polar_surface_area 307.5 ChemAxon refractivity 79.27 ChemAxon polarizability 34.03 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 14 ChemAxon donor_count 10 ChemAxon physiological_charge -8 ChemAxon formal_charge 0 ChemAxon Inositol Metabolism SMP00011 map00562 Inositol Phosphate Metabolism SMP00462 map00562 Specdb::CMs 2395 Specdb::CMs 38765 Specdb::CMs 166582 Specdb::MsMs 178065 Specdb::MsMs 178066 Specdb::MsMs 178067 Specdb::MsMs 180378 Specdb::MsMs 180379 Specdb::MsMs 180380 Specdb::MsMs 2696592 Specdb::MsMs 2696593 Specdb::MsMs 2696594 Specdb::MsMs 2982866 Specdb::MsMs 2982867 Specdb::MsMs 2982868 Specdb::NmrOneD 149880 Specdb::NmrOneD 149881 Specdb::NmrOneD 149882 Specdb::NmrOneD 149883 Specdb::NmrOneD 149884 Specdb::NmrOneD 149885 Specdb::NmrOneD 149886 Specdb::NmrOneD 149887 Specdb::NmrOneD 149888 Specdb::NmrOneD 149889 Specdb::NmrOneD 149890 Specdb::NmrOneD 149891 Specdb::NmrOneD 149892 Specdb::NmrOneD 149893 Specdb::NmrOneD 149894 Specdb::NmrOneD 149895 Specdb::NmrOneD 149896 Specdb::NmrOneD 149897 Specdb::NmrOneD 149898 Specdb::NmrOneD 149899 HMDB04527 16067 #<Reference:0x000055ce324829b0> #<Reference:0x000055ce324827f8> #<Reference:0x000055ce32482640> #<Reference:0x000055ce32482488> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Inositol polyphosphate multikinase Q8NFU5 IPMK