1.0 2011-09-21 00:29:09 UTC 2025-11-19 02:43:56 UTC FDB023386 Calusterone Calusterone is an androgenic steroid. Calusterone induce given orally induce a marked decrease (between 30 and 70% depending on the dose) in the binding capacity of oestradiol-17beta to specific uterine receptors in vivo. As an androgen, calusterone has been used as a therapeutic agent in postmenopausal women with metastatic breast cancer; the addition of a potent hormonal agent to effective cytotoxic chemotherapy improves the results of treatment of women with metastatic breast cancer. Calusterone is tested in sport screening; fast and sensitive method for the comprehensive screening of anabolic agents and other banned doping substances using gas chromatography/tandem mass spectrometry (GC/MS/MS) with an external ionization ion trap mass spectrometer have been developed for the parent substances and their metabolites. (PMID: 17610244, 12375280, 153787, 2325376, 12375280) [HMDB] (7b,17b)-17-hydroxy-7,17-dimethyl-Androst-4-en-3-one 17-beta-hydroxy-7-beta-17-dimethyl androst-4-en-3-one 17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one 17-dimethyl-17beta-hydroxy-7beta-Androst-4-en-3-one 17-hydroxy-7,17-dimethylandrost-4-en-3-one 17b-hydroxy-7b,17-dimethyl-Androst-4-en-3-one 17b-Hydroxy-7b,17-dimethylandrost-4-en-3-one 17beta-Dimethyl testosterone 17beta-Hydroxy-7beta-17-dimethylandrost-4-en-3-one 17beta-Hydroxy-7beta-17alpha-dimethylandrost-4-ene-3-one 7-beta-17-alpha-dimethyltestosterone 7-beta,17-alpha-Dimethyl testosterone 7-beta,17-Dimethyltestosterone 7beta-Dimethyltestosterone 7beta,17alpha-Dimethyltestosterone 7beta,17beta-Dimethyltestosterone Calusteron Calusterona Calusteronum Dimethyltestosterone Methosarb C21H32O2 316.4776 316.240230268 (1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one calusterone 17021-26-0 [H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](C)CC2=CC(=O)CC[C@]12C InChI=1S/C21H32O2/c1-13-11-14-12-15(22)5-8-19(14,2)16-6-9-20(3)17(18(13)16)7-10-21(20,4)23/h12-13,16-18,23H,5-11H2,1-4H3/t13-,16-,17-,18+,19-,20-,21-/m0/s1 IVFYLRMMHVYGJH-PVPPCFLZSA-N belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. Androgens and derivatives Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Androstane steroids Aliphatic homopolycyclic compounds 17-hydroxysteroids 3-oxo delta-4-steroids Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Organic oxides Tertiary alcohols 17-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aliphatic homopolycyclic compound Androgen-skeleton Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Hydroxysteroid Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Tertiary alcohol Solid logp 3.55 ALOGPS logs -4.45 ALOGPS solubility 1.12e-02 g/l ALOGPS logp 3.93 ChemAxon pka_strongest_acidic 19.56 ChemAxon pka_strongest_basic -0.53 ChemAxon iupac (1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one ChemAxon average_mass 316.4776 ChemAxon mono_mass 316.240230268 ChemAxon smiles [H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](C)CC2=CC(=O)CC[C@]12C ChemAxon formula C21H32O2 ChemAxon inchi InChI=1S/C21H32O2/c1-13-11-14-12-15(22)5-8-19(14,2)16-6-9-20(3)17(18(13)16)7-10-21(20,4)23/h12-13,16-18,23H,5-11H2,1-4H3/t13-,16-,17-,18+,19-,20-,21-/m0/s1 ChemAxon inchikey IVFYLRMMHVYGJH-PVPPCFLZSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 93.62 ChemAxon polarizability 37.77 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 11430 Specdb::CMs 38773 Specdb::CMs 153642 Specdb::MsMs 251640 Specdb::MsMs 251641 Specdb::MsMs 251642 Specdb::MsMs 271581 Specdb::MsMs 271582 Specdb::MsMs 271583 Specdb::MsMs 2381912 Specdb::MsMs 2381913 Specdb::MsMs 2381914 Specdb::MsMs 2581221 Specdb::MsMs 2581222 Specdb::MsMs 2581223 HMDB04627 #<Reference:0x000055ce31ca8eb0> #<Reference:0x000055ce31ca8ca8> #<Reference:0x000055ce31ca8ac8> #<Reference:0x000055ce31ca8910>