1.0 2011-09-21 00:29:15 UTC 2015-07-21 06:57:41 UTC FDB023392 8-Isoprostane 8-isoprostane concentrations are elevated in asthma and increase with the clinical severity and during acute asthma episodes. Isoprostane is formed in the airways of asthmatic patients from peroxidation of poly-unsaturated fatty acids in cell membranes, the effect of reactive oxygen species resulting of the NADPH oxidase of eosinophils, neutrophils and alveolar macrophages, which produces superoxide anion which undergoes dismutation to H2O2. (PMID 16354413) 8-isoprostane is also elevated in Bronchopulmonary dysplasia, which remains an important cause of morbidity and mortality in extremely premature newborn infants receiving intensive care and is the most common contributing factor to severe respiratory morbidity and mortality in early childhood. (PMID 14980283) 8-Isoprostaglandin F(2a) is a marker of oxidative stress in the aqueous humour of patients with exfoliation syndrome (XFS) (PubMed ID 12598453) [HMDB] (1R,2S)-1-Heptyl-2-octylcyclopentane (8b)-Prostane (8beta)-Prostane (8β)-prostane 8-beta-prostane 8-Isoprostane C20H40 280.5316 280.31300128 (1R,2S)-1-heptyl-2-octylcyclopentane 8β-prostane 155976-51-5 [H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCC InChI=1S/C20H40/c1-3-5-7-9-11-13-16-20-18-14-17-19(20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m1/s1 UKVVPDHLUHAJNZ-UXHICEINSA-N belongs to the class of organic compounds known as cycloalkanes. These are saturated monocyclic hydrocarbons (with or without side chains). Cycloalkanes Organic compounds Hydrocarbons Saturated hydrocarbons Cycloalkanes Aliphatic homomonocyclic compounds Aliphatic homomonocyclic compound Cycloalkane 1-heptyl-2-octylcyclopentane Solid logp 9.29 ALOGPS logs -7.56 ALOGPS solubility 7.76e-06 g/l ALOGPS logp 8.58 ChemAxon iupac (1R,2S)-1-heptyl-2-octylcyclopentane ChemAxon average_mass 280.5316 ChemAxon mono_mass 280.31300128 ChemAxon smiles [H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCC ChemAxon formula C20H40 ChemAxon inchi InChI=1S/C20H40/c1-3-5-7-9-11-13-16-20-18-14-17-19(20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m1/s1 ChemAxon inchikey UKVVPDHLUHAJNZ-UXHICEINSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 91.92 ChemAxon polarizability 40.05 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Arachidonic Acid Metabolism SMP00075 map00590 Specdb::CMs 21612 Specdb::CMs 135175 Specdb::CMs 142909 Specdb::MsMs 69711 Specdb::MsMs 69712 Specdb::MsMs 69713 Specdb::MsMs 128043 Specdb::MsMs 128044 Specdb::MsMs 128045 Specdb::MsMs 2421492 Specdb::MsMs 2421493 Specdb::MsMs 2421494 Specdb::MsMs 2544892 Specdb::MsMs 2544893 Specdb::MsMs 2544894 HMDB04659 #<Reference:0x00007f093c029558> #<Reference:0x00007f093c029300> #<Reference:0x00007f093c0290d0> #<Reference:0x00007f093c028ea0> #<Reference:0x00007f093c028cc0> #<Reference:0x00007f093c028a40> #<Reference:0x00007f093c028888> #<Reference:0x00007f093c0286a8> #<Reference:0x00007f093c028450> #<Reference:0x00007f093c028298> #<Reference:0x00007f093c028090> #<Reference:0x000055ce331afe08> #<Reference:0x000055ce331afc50> #<Reference:0x000055ce331afa48> #<Reference:0x000055ce331af840> #<Reference:0x000055ce331af688> #<Reference:0x000055ce331af480> #<Reference:0x000055ce331af278> #<Reference:0x000055ce331af0c0> #<Reference:0x000055ce331aeeb8> #<Reference:0x000055ce331aecb0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823