1.0 2011-09-21 00:31:50 UTC 2015-10-09 22:33:02 UTC FDB023575 Guaifenesin Guaifenesin (INN) or guaiphenesin (former BAN) is an expectorant drug usually taken orally to assist the expectoration ('bringing up') of phlegm from the airways in acute respiratory tract infections. It is a common ingredient in many over-the-counter cough/cold medications. Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia. It was first approved by the Food and Drug Administration (FDA) in 1952. Guaifenesin works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing. [HMDB] 3-(2-Methoxyphenoxy)-1,2-propanediol 3-(o-Methoxyphenoxy)-1,2-propanediol 3-(o-Methoxyphenoxy)-propanediol-1,2 3-o-Methoxyphenoxypropane 1:2-diol a-Glyceryl guaiacol ether a-Glyceryl guaiacolate ether Actifed C Aeronesin alpha-Glyceryl guaiacol ether alpha-Glyceryl guaiacolate ether Amonidren Amonidrin Aresol Benylin-E Bronchol glycerin ether Glycerin guaiacolate Glycero-guaiacol ether Glycerol a-(2-methoxyphenyl) ether Glycerol a-(o-methoxyphenyl)ether Glycerol a-guaiacyl ether Glycerol a-guiacyl ether Glycerol a-monoguaiacol ether Glycerol guaiacolate Glycerol mono(2-methoxyphenyl) ether Glycerol-a-guajakolether Glycerol-alpha-guajakolether Glyceryl guaiacol Glyceryl guaiacol ether Glyceryl guaiacolate Glyceryl guaiacolate ether Glyceryl guaiacyl ether Glyceryl guaicolate Glyceryl guiacolate Glycerylguaiacol Guaiacol glycerol ether Guaiacol glyceryl ether Guaiacolglicerinetere Guaiacuran Guaiacurane Guaiacyl glyceryl ether Guaiamar Guaianesin Guaicol glycerine ether Guaicol glyceryl ether Guaifenesin Guaifenesine Guaiphenesin Guaiphenesine Guaiphesin Hustosil Methoxypropanediol Methphenoxydiol Metossipropandiolo o-Methoxyphenyl glyceryl ether Organidin NR Pneumomist Propanosedyl Reduton Robitussin C10H14O4 198.2158 198.089208936 3-(2-methoxyphenoxy)propane-1,2-diol guaifenesin 93-14-1 COC1=CC=CC=C1OCC(O)CO InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 HSRJKNPTNIJEKV-UHFFFAOYSA-N belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. Anisoles Organic compounds Benzenoids Phenol ethers Anisoles Aromatic homomonocyclic compounds 1,2-diols Alkyl aryl ethers Hydrocarbon derivatives Methoxybenzenes Phenoxy compounds Primary alcohols Secondary alcohols 1,2-diol Alcohol Alkyl aryl ether Anisole Aromatic homomonocyclic compound Ether Hydrocarbon derivative Methoxybenzene Monocyclic benzene moiety Organic oxygen compound Organooxygen compound Phenoxy compound Primary alcohol Secondary alcohol Solid logp 0.76 ALOGPS logs -1.12 ALOGPS solubility 1.49e+01 g/l ALOGPS logp 0.34 ChemAxon pka_strongest_acidic 13.62 ChemAxon pka_strongest_basic -3 ChemAxon iupac 3-(2-methoxyphenoxy)propane-1,2-diol ChemAxon average_mass 198.2158 ChemAxon mono_mass 198.089208936 ChemAxon smiles COC1=CC=CC=C1OCC(O)CO ChemAxon formula C10H14O4 ChemAxon inchi InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 ChemAxon inchikey HSRJKNPTNIJEKV-UHFFFAOYSA-N ChemAxon polar_surface_area 58.92 ChemAxon refractivity 51.24 ChemAxon polarizability 20.59 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 379 Specdb::NmrTwoD 1948 Specdb::MsIr 2276 Specdb::MsIr 2277 Specdb::MsIr 2278 Specdb::CMs 22869 Specdb::CMs 38831 Specdb::CMs 121187 Specdb::CMs 146327 Specdb::CMs 829061 Specdb::CMs 829062 Specdb::CMs 829063 Specdb::CMs 829064 Specdb::CMs 829065 Specdb::MsMs 104907 Specdb::MsMs 104908 Specdb::MsMs 104909 Specdb::MsMs 171276 Specdb::MsMs 171277 Specdb::MsMs 171278 Specdb::MsMs 374268 Specdb::MsMs 450731 Specdb::MsMs 2427106 Specdb::MsMs 2427107 Specdb::MsMs 2427108 Specdb::MsMs 2512035 Specdb::MsMs 2512036 Specdb::MsMs 2512037 Specdb::NmrOneD 2013 Specdb::NmrOneD 2705 Specdb::NmrOneD 3396 Specdb::NmrOneD 54882 Specdb::NmrOneD 54883 Specdb::NmrOneD 54884 Specdb::NmrOneD 54885 Specdb::NmrOneD 54886 Specdb::NmrOneD 54887 Specdb::NmrOneD 54888 Specdb::NmrOneD 54889 Specdb::NmrOneD 54890 Specdb::NmrOneD 54891 Specdb::NmrOneD 54892 Specdb::NmrOneD 54893 Specdb::NmrOneD 54894 Specdb::NmrOneD 54895 Specdb::NmrOneD 54896 Specdb::NmrOneD 54897 Specdb::NmrOneD 54898 Specdb::NmrOneD 54899 Specdb::NmrOneD 54900 Specdb::NmrOneD 54901 HMDB04998 #<Reference:0x000055ce31cef310> bitter