1.0 2011-09-21 00:31:59 UTC 2015-07-21 06:57:46 UTC FDB023585 Olanzapine Olanzapine was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression. It has also been established in treating depression off-label because of its mood-stabilizing properties and its ability to increase the efficacy of antidepressants. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company. It is available as a pill that comes in the strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg and as as Zydis orally disintegrating tablets in the strengths of 5 mg, 10 mg, 15 mg, and 20 mg. It is also available as a rapid-acting intramuscular injection for short term acute use.; Olanzapine (oh-LAN-za-peen, sold as Zyprexa, Zydis, or in combination with fluoxetine, as Symbyax) was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression. [HMDB] Lanzac Olanzapina Olanzapine Olanzapinum Zyprexa Zyprexa Intramuscular Zyprexa Zydis C17H20N4S 312.432 312.14086735 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,8,10,12-hexaene zyprexa 132539-06-1 CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 KVWDHTXUZHCGIO-UHFFFAOYSA-N belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms). Benzodiazepines Organic compounds Organoheterocyclic compounds Benzodiazepines Aromatic heteropolycyclic compounds 1,4-diazepines 2,3,5-trisubstituted thiophenes Azacyclic compounds Benzenoids Carboxamidines Heteroaromatic compounds Hydrocarbon derivatives Imidolactams N-arylated-2-aminothiophenes N-methylpiperazines Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Secondary amines Thienodiazepines Trialkylamines 1,4-diazinane 2,3,5-trisubstituted thiophene 2-aminothiophene Amidine Amine Aromatic heteropolycyclic compound Azacycle Benzenoid Benzodiazepine Carboxylic acid amidine Heteroaromatic compound Hydrocarbon derivative Imidolactam N-alkylpiperazine N-arylated-2-aminothiophene N-methylpiperazine Organic 1,3-dipolar compound Organic nitrogen compound Organonitrogen compound Organopnictogen compound Para-diazepine Piperazine Propargyl-type 1,3-dipolar organic compound Secondary amine Tertiary aliphatic amine Tertiary amine Thieno-para-diazepine Thiophene N-arylpiperazine N-methylpiperazine benzodiazepine Solid logp 3.61 ALOGPS logs -3.52 ALOGPS solubility 9.42e-02 g/l ALOGPS logp 3.39 ChemAxon pka_strongest_acidic 14.17 ChemAxon pka_strongest_basic 7.24 ChemAxon iupac 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),5,8,10,12-hexaene ChemAxon average_mass 312.432 ChemAxon mono_mass 312.14086735 ChemAxon smiles CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 ChemAxon formula C17H20N4S ChemAxon inchi InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 ChemAxon inchikey KVWDHTXUZHCGIO-UHFFFAOYSA-N ChemAxon polar_surface_area 30.87 ChemAxon refractivity 93.87 ChemAxon polarizability 35.37 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 4 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 16150 Specdb::CMs 132250 Specdb::CMs 139984 Specdb::MsMs 49164 Specdb::MsMs 49165 Specdb::MsMs 49166 Specdb::MsMs 114738 Specdb::MsMs 114739 Specdb::MsMs 114740 Specdb::MsMs 374330 Specdb::MsMs 374383 Specdb::MsMs 374943 Specdb::MsMs 441068 Specdb::MsMs 441069 Specdb::MsMs 441070 Specdb::MsMs 441071 Specdb::MsMs 441072 Specdb::MsMs 450853 Specdb::MsMs 450854 Specdb::MsMs 450969 Specdb::MsMs 450970 Specdb::MsMs 451707 Specdb::MsMs 2227090 Specdb::MsMs 2227493 Specdb::MsMs 2236362 Specdb::MsMs 2237043 Specdb::MsMs 2238421 Specdb::MsMs 2239138 HMDB05012 #<Reference:0x000055ce32596478> #<Reference:0x000055ce325962c0> #<Reference:0x000055ce32596108> #<Reference:0x000055ce32595f50> #<Reference:0x000055ce32595d98> D(2) dopamine receptor P14416 DRD2 D(4) dopamine receptor P21917 DRD4 Histamine H1 receptor P35367 HRH1