1.0 2011-09-21 00:32:02 UTC 2015-07-21 06:57:46 UTC FDB023589 Pantoprazole Pantozol; Pantoprazole (brand names Pantopan in Italy; Protium; Protonix; Pantozol; Pantor; Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained; Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained. Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance; Protium; Pantor; Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained; Protonix; Pantoprazole (brand names Pantopan in Italy [HMDB] Pantoloc Pantoprazol Pantoprazole sodium Pantoprazole Sodium Hydrate Pantoprazolum Pantozol Protonix Protonix I.V. C16H15F2N3O4S 383.37 383.075133083 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole pantoprazole 102625-70-7 COC1=C(OC)C(CS(=O)C2=NC3=C(N2)C=C(OC(F)F)C=C3)=NC=C1 InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21) IQPSEEYGBUAQFF-UHFFFAOYSA-N belongs to the class of organic compounds known as sulfinylbenzimidazoles. These are polycyclic aromatic compounds containing a sulfinyl group attached at the position 2 of a benzimidazole moiety. Sulfinylbenzimidazoles Organic compounds Organoheterocyclic compounds Benzimidazoles Sulfinylbenzimidazoles Aromatic heteropolycyclic compounds Alkyl aryl ethers Alkyl fluorides Azacyclic compounds Benzenoids Heteroaromatic compounds Hydrocarbon derivatives Imidazoles Organic oxides Organofluorides Organonitrogen compounds Organopnictogen compounds Pyridines and derivatives Sulfinyl compounds Sulfoxides Alkyl aryl ether Alkyl fluoride Alkyl halide Aromatic heteropolycyclic compound Azacycle Azole Benzenoid Ether Heteroaromatic compound Hydrocarbon derivative Imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfur compound Pyridine Sulfinyl compound Sulfinylbenzimidazole Sulfoxide aromatic ether benzimidazoles organofluorine compound pyridines sulfoxide Solid logp 2.11 ALOGPS logs -2.89 ALOGPS solubility 4.95e-01 g/l ALOGPS logp 2.18 ChemAxon pka_strongest_acidic 9.15 ChemAxon pka_strongest_basic 3.55 ChemAxon iupac 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole ChemAxon average_mass 383.37 ChemAxon mono_mass 383.075133083 ChemAxon smiles COC1=C(OC)C(CS(=O)C2=NC3=C(N2)C=C(OC(F)F)C=C3)=NC=C1 ChemAxon formula C16H15F2N3O4S ChemAxon inchi InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21) ChemAxon inchikey IQPSEEYGBUAQFF-UHFFFAOYSA-N ChemAxon polar_surface_area 86.33 ChemAxon refractivity 90.05 ChemAxon polarizability 35.17 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 6 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 14386 Specdb::CMs 128918 Specdb::CMs 166754 Specdb::MsMs 55479 Specdb::MsMs 55480 Specdb::MsMs 55481 Specdb::MsMs 110634 Specdb::MsMs 110635 Specdb::MsMs 110636 Specdb::MsMs 435797 Specdb::MsMs 435798 Specdb::MsMs 435799 Specdb::MsMs 435800 Specdb::MsMs 435801 Specdb::MsMs 435802 Specdb::MsMs 435803 Specdb::MsMs 435804 Specdb::MsMs 435805 Specdb::MsMs 435806 Specdb::MsMs 435807 Specdb::MsMs 435808 Specdb::MsMs 435809 Specdb::MsMs 435810 Specdb::MsMs 440589 Specdb::MsMs 442225 Specdb::MsMs 442226 Specdb::MsMs 442227 Specdb::MsMs 442228 HMDB05017 bitter Potassium-transporting ATPase alpha chain 1 P20648 ATP4A Potassium-transporting ATPase alpha chain 2 P54707 ATP12A