1.0 2011-09-21 00:32:03 UTC 2015-10-09 22:33:19 UTC FDB023590 Amlodipine Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell; A long acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension; in angina it improves blood flow to the myocardium.; Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. [HMDB] 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid Amlodipine besilate Amlodipine besylate Amlodipine free base Amlodipino Amlodipinum AMVAZ Istin Norvasc Pelmec Racemic Amlodipine C20H25ClN2O5 408.876 408.145199627 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (+-)-amlodipine 88150-42-9 CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 HTIQEAQVCYTUBX-UHFFFAOYSA-N belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. Dihydropyridinecarboxylic acids and derivatives are compounds containing a dihydropyridine moiety bearing a carboxylic acid group. Dihydropyridinecarboxylic acids and derivatives Organic compounds Organoheterocyclic compounds Pyridines and derivatives Hydropyridines Aromatic heteromonocyclic compounds Amino acids and derivatives Aryl chlorides Azacyclic compounds Carbonyl compounds Chlorobenzenes Dialkyl ethers Dialkylamines Dicarboxylic acids and derivatives Enamines Enoate esters Hydrocarbon derivatives Methyl esters Monoalkylamines Organic oxides Organochlorides Organopnictogen compounds Vinylogous amides Alpha,beta-unsaturated carboxylic ester Amine Amino acid or derivatives Aromatic heteromonocyclic compound Aryl chloride Aryl halide Azacycle Benzenoid Carbonyl group Carboxylic acid derivative Carboxylic acid ester Chlorobenzene Dialkyl ether Dicarboxylic acid or derivatives Dihydropyridinecarboxylic acid derivative Enamine Enoate ester Ether Halobenzene Hydrocarbon derivative Methyl ester Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Primary aliphatic amine Primary amine Secondary aliphatic amine Secondary amine Vinylogous amide dihydropyridine ethyl ester methyl ester monochlorobenzenes primary amino compound Solid logp 2.22 ALOGPS logs -4.74 ALOGPS solubility 7.40e-03 g/l ALOGPS logp 1.64 ChemAxon pka_strongest_acidic 19.12 ChemAxon pka_strongest_basic 9.45 ChemAxon iupac 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ChemAxon average_mass 408.876 ChemAxon mono_mass 408.145199627 ChemAxon smiles CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC ChemAxon formula C20H25ClN2O5 ChemAxon inchi InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 ChemAxon inchikey HTIQEAQVCYTUBX-UHFFFAOYSA-N ChemAxon polar_surface_area 99.88 ChemAxon refractivity 108.64 ChemAxon polarizability 42.31 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrTwoD 1955 Specdb::NmrOneD 2020 Specdb::CMs 16864 Specdb::CMs 121305 Specdb::CMs 169722 Specdb::MsMs 245253 Specdb::MsMs 245254 Specdb::MsMs 245255 Specdb::MsMs 265200 Specdb::MsMs 265201 Specdb::MsMs 265202 Specdb::MsMs 441085 Specdb::MsMs 450768 Specdb::MsMs 2248883 Specdb::MsMs 2249487 Specdb::MsMs 2249636 Specdb::MsMs 2833434 Specdb::MsMs 2833435 Specdb::MsMs 2833436 Specdb::MsMs 2849551 Specdb::MsMs 2849552 Specdb::MsMs 2849553 HMDB05018 #<Reference:0x000055ce300ac748> #<Reference:0x000055ce300ac590>