1.0 2011-09-21 00:32:04 UTC 2015-07-21 06:57:46 UTC FDB023591 Risperidone Risperidone is an atypical antipsychotic medication approved in 1993. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone (like other atypical antipsychotics) is also used to treat some forms of bipolar disorder, psychotic depression and Tourette syndrome. Generally lower doses are used for autistic spectrum disorders than are used for schizophrenia and other forms of psychosis; Risperidone is a very strong dopamine blocker (antagonist); Risperidone is a very strong dopamine blocker (antagonist); i.e., it inhibits functioning of postsynaptic dopamine receptors.; An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam; i.e., it inhibits functioning of postsynaptic dopamine receptors.; Risperidone (Belivon, Rispen, Risperdal; in the United States) is an atypical antipsychotic medication. It was approved by the United States Food and Drug Administration (FDA) in 1993. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone (like other atypical antipsychotics) is also used to treat some forms of bipolar disorder, psychotic depression and Tourette syndrome; risperidone has received approval from the Food and Drug Administration (FDA) for symptomatic treatment of irritability in autistic children and adolescents. Risperidone is now the most commonly prescribed antipsychotic medication in the United States. [HMDB] Belivon Buspirone Rispen Risperdal Risperdal M-Tab Risperidona Risperidone Risperidonum Risperin Rispolept Rispolin Sequinan Spiron C23H27FN4O2 410.4845 410.211804333 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one risperidone 106266-06-2 CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCCC2=N1 InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 RAPZEAPATHNIPO-UHFFFAOYSA-N belongs to the class of organic compounds known as pyridopyrimidines. Pyridopyrimidines are compounds containing a pyridopyrimidine, which consists of a pyridine fused to a pyrimidine. Pyridine is 6-membered ring consisting of five carbon atoms and a nitrogen atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. Pyridopyrimidines Organic compounds Organoheterocyclic compounds Pyridopyrimidines Aromatic heteropolycyclic compounds Aralkylamines Aryl fluorides Azacyclic compounds Benzenoids Benzisoxazoles Heteroaromatic compounds Hydrocarbon derivatives Isoxazoles Lactams Organic oxides Organofluorides Organooxygen compounds Organopnictogen compounds Oxacyclic compounds Piperidines Pyridines and derivatives Pyrimidones Trialkylamines Amine Aralkylamine Aromatic heteropolycyclic compound Aryl fluoride Aryl halide Azacycle Azole Benzenoid Benzisoxazole Heteroaromatic compound Hydrocarbon derivative Isoxazole Lactam Organic nitrogen compound Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Piperidine Pyridine Pyridopyrimidine Pyrimidine Pyrimidone Tertiary aliphatic amine Tertiary amine 1,2-benzoxazoles heteroarylpiperidine organofluorine compound pyridopyrimidine Solid logp 3.27 ALOGPS logs -3.38 ALOGPS solubility 1.71e-01 g/l ALOGPS logp 2.63 ChemAxon pka_strongest_basic 8.76 ChemAxon iupac 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one ChemAxon average_mass 410.4845 ChemAxon mono_mass 410.211804333 ChemAxon smiles CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCCC2=N1 ChemAxon formula C23H27FN4O2 ChemAxon inchi InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 ChemAxon inchikey RAPZEAPATHNIPO-UHFFFAOYSA-N ChemAxon polar_surface_area 61.94 ChemAxon refractivity 114.55 ChemAxon polarizability 45.27 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 4 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 21084 Specdb::CMs 165200 Specdb::MsMs 64044 Specdb::MsMs 64045 Specdb::MsMs 64046 Specdb::MsMs 121098 Specdb::MsMs 121099 Specdb::MsMs 121100 Specdb::MsMs 441049 Specdb::MsMs 441050 Specdb::MsMs 441051 Specdb::MsMs 441052 Specdb::MsMs 441053 Specdb::MsMs 444317 Specdb::MsMs 444318 Specdb::MsMs 444319 Specdb::MsMs 444320 Specdb::MsMs 444321 Specdb::MsMs 444322 Specdb::MsMs 444323 Specdb::MsMs 444324 Specdb::MsMs 444325 Specdb::MsMs 450691 Specdb::MsMs 450692 Specdb::MsMs 450971 Specdb::MsMs 450972 Specdb::MsMs 451572 HMDB05020 Beta-1 adrenergic receptor P08588 ADRB1 D(2) dopamine receptor P14416 DRD2 Histamine H1 receptor P35367 HRH1