1.0 2011-09-21 00:32:06 UTC 2015-07-21 06:57:47 UTC FDB023593 Pravastatin Pravastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Pravastatin was identified originally in a mold called Nocardia autotrophica by researchers of the Sankyo Pharma Inc; An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (hydroxymethylglutaryl CoA reductases); In medicine and pharmacology, pravastatin (Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. [HMDB] (+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoate (+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid (3R,5R)-7-[(1S,2S,6S,8S,8AR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid 3beta-Hydroxycompactin Eptastatin Mevalothin Pravachol Pravastatin acid Pravastatin sodium Pravastatina Pravastatine Pravastatinum Selektine C23H36O7 424.5277 424.246103506 (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid PRAV 81093-37-0 [H][C@@](O)(CC[C@]1([H])C2C(C=C[C@]1([H])C)=C[C@@]([H])(O)C[C@]2([H])OC(=O)[C@@]([H])(C)CC)C[C@@]([H])(O)CC(O)=O InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22?/m0/s1 TUZYXOIXSAXUGO-HBFVYRAQSA-N belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain. Medium-chain hydroxy acids and derivatives Organic compounds Organic acids and derivatives Hydroxy acids and derivatives Medium-chain hydroxy acids and derivatives Aliphatic homopolycyclic compounds Beta hydroxy acids and derivatives Branched fatty acids Carbonyl compounds Carboxylic acid esters Carboxylic acids Dicarboxylic acids and derivatives Fatty acid esters Fatty alcohols Hydrocarbon derivatives Hydroxy fatty acids Medium-chain fatty acids Organic oxides Secondary alcohols Alcohol Aliphatic homopolycyclic compound Beta-hydroxy acid Branched fatty acid Carbonyl group Carboxylic acid Carboxylic acid derivative Carboxylic acid ester Dicarboxylic acid or derivatives Fatty acid ester Fatty acyl Fatty alcohol Hydrocarbon derivative Hydroxy fatty acid Medium-chain fatty acid Medium-chain hydroxy acid Organic oxide Organic oxygen compound Organooxygen compound Secondary alcohol Solid logp 2.23 ALOGPS logs -3.24 ALOGPS solubility 2.42e-01 g/l ALOGPS logp 1.65 ChemAxon pka_strongest_acidic 4.21 ChemAxon pka_strongest_basic -2.7 ChemAxon iupac (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid ChemAxon average_mass 424.5277 ChemAxon mono_mass 424.246103506 ChemAxon smiles [H][C@@](O)(CC[C@]1([H])C2C(C=C[C@]1([H])C)=C[C@@]([H])(O)C[C@]2([H])OC(=O)[C@@]([H])(C)CC)C[C@@]([H])(O)CC(O)=O ChemAxon formula C23H36O7 ChemAxon inchi InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22?/m0/s1 ChemAxon inchikey TUZYXOIXSAXUGO-HBFVYRAQSA-N ChemAxon polar_surface_area 124.29 ChemAxon refractivity 113.6 ChemAxon polarizability 46.24 ChemAxon rotatable_bond_count 11 ChemAxon acceptor_count 6 ChemAxon donor_count 4 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon HMDB05022 #<Reference:0x000055ce316a2c50> #<Reference:0x000055ce316a2a70> #<Reference:0x000055ce316a28b8> #<Reference:0x000055ce316a2688> #<Reference:0x000055ce316a24d0> #<Reference:0x000055ce316a22a0> #<Reference:0x000055ce316a2098> 3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMGCR