1.0 2011-09-21 00:32:07 UTC 2015-07-21 06:57:47 UTC FDB023594 Zolpidem Some users take zolpidem recreationally for these side effects. However, it may be less common than benzodiazepine abuse. In the United States, recreational use may be less common than in countries where the drug is available as a less expensive generic. Zolpidem can become addictive if taken for extended periods of time, due to dependence on its ability to put one to sleep or to the euphoria it can sometimes produce. Like most addictive drugs, a tolerance in the zolpidem user develops and increases all the more quickly the longer she or he has been regularly taking it. Under the influence of the drug it is common to take more zolpidem than is necessary due to either forgetting that one has already taken a pill (elderly users are particularly at risk here), or knowingly taking more than the prescribed dosage. Users with a predilection for abuse are advised to keep additional zolpidem in a safe place that is unlikely to be remembered or accessed while intoxicated to avoid this risk. A trustworthy friend or relative is the best defense if such people are available; otherwise, a box or cupboard locked with a combination padlock is a good defense against this tendency, as the abovementioned side-effects can easily prevent a user from operating such a lock while under the drug's influence; Zolpidem is a prescription drug used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). Some trade names of zolpidem are Ambien, Stilnox, Stilnoct, Hypnogen or Myslee. Its hypnotic effects are similar to those of the benzodiazepines, but it is classified as an imidazopyridine, and the anticonvulsant and muscle relaxant effects only appear at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Such drastically increased doses are more likely to induce one or more negative side effects, including hallucinations and/or amnesia. (See below.); Some users take zolpidem recreationally for these side effects. However, it may be less common than benzodiazepine abuse. In the United States, recreational use may be less common than in countries where the drug is available as a less expensive generic. Zolpidem can become addictive if taken for extended periods of time, due to dependence on its ability to put one to sleep or to the euphoria it can sometimes produce. Like most addictive drugs, a tolerance in the zolpidem user develops and increases all the more quickly the longer she or he has been regularly taking it. Under the influence of the drug it is common to take more zolpidem than is necessary due to either forgetting that one has already taken a pill (elderly users are particularly at risk here), or knowingly taking more than the prescribed dosage. Users with a predilection for abuse are advised to keep additional zolpidem in a safe place that is unlikely to be remembered or accessed while intoxicated to avoid this risk. A trustworthy friend or relative is the best defense if such people are available; Recreational zolpidem use is speculated to lead to tolerance and dependence much more quickly than prescribed use. Recreational use is rising, as demonstrated by the use of street names for the pill, such as: 'A' (which is most likely due to the imprint on the Ambien CR brand of zolpidem, which consists of a capital A along with a tilde, which looks roughly like A~, as well as for sedative and calming effects, 'A+' is a street name for Adderall, named so because of its stimulant effects) and 'zombie pills' (because of the waking sleep/sensory deprivation effect some users have reported experiencing). Another buzz term for Ambien is 'tic-tacs', referring to the shape and color of commonly abused 10mg tablets; Zolpidem is a prescription drug used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). Its hypnotic effects are similar to those of the benzodiazepines, but it is actually classified as an imidazopyridine, and the anticonvulsant and muscle relaxant effects only appear at 10 and 20 times the dose required for sedation, respectively.[2] For that reason, it has never been approved for either muscle relaxation or seizure prevention. Such drastically increased doses are likely to induce one or more negative side effects, including hallucinations and/or amnesia.; Zolpidem is a prescription drug used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). Some trade names of zolpidem are Ambien, Stilnox, Stilnoct, Hypnogen or Myslee. Its hypnotic effects are similar to those of the benzodiazepines, but it is actually classified as an imidazopyridine, and the anticonvulsant and muscle relaxant effects only appear at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Such drastically increased doses are more inclined to induce one or more negative side effects, including hallucinations and/or amnesia. (See below.); otherwise, a box or cupboard locked with a combination padlock is a good defense against this tendency, as the abovementioned side-effects can easily prevent a user from operating such a lock while under the drug's influence. [HMDB] Ambien Hypnogen Myslee N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamide Stilnoct Stilnox zolpidem Ambien Zolpidem tartrate Zolpidemum C19H21N3O 307.3895 307.168462309 N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide zolpidem 82626-48-0 CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond. Phenylimidazoles Organic compounds Organoheterocyclic compounds Azoles Imidazoles Aromatic heteropolycyclic compounds Azacyclic compounds Carbonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Imidazo[1,2-a]pyridines Imidazopyridines Methylpyridines N-substituted imidazoles Organic oxides Organonitrogen compounds Organopnictogen compounds Tertiary carboxylic acid amides Toluenes 4-phenylimidazole 5-phenylimidazole Aromatic heteropolycyclic compound Azacycle Benzenoid Carbonyl group Carboxamide group Carboxylic acid derivative Heteroaromatic compound Hydrocarbon derivative Imidazo[1,2-a]pyridine Imidazopyridine Methylpyridine Monocyclic benzene moiety N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyridine Tertiary carboxylic acid amide Toluene imidazopyridine Solid logp 3.15 ALOGPS logs -3.99 ALOGPS solubility 3.13e-02 g/l ALOGPS logp 3.02 ChemAxon pka_strongest_basic 5.65 ChemAxon iupac N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide ChemAxon average_mass 307.3895 ChemAxon mono_mass 307.168462309 ChemAxon smiles CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1 ChemAxon formula C19H21N3O ChemAxon inchi InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ChemAxon inchikey ZAFYATHCZYHLPB-UHFFFAOYSA-N ChemAxon polar_surface_area 37.61 ChemAxon refractivity 93.58 ChemAxon polarizability 35.06 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 254 Specdb::CMs 20168 Specdb::CMs 130510 Specdb::CMs 138244 Specdb::MsMs 101799 Specdb::MsMs 101800 Specdb::MsMs 101801 Specdb::MsMs 167484 Specdb::MsMs 167485 Specdb::MsMs 167486 Specdb::MsMs 450973 Specdb::MsMs 2247939 Specdb::MsMs 2291595 Specdb::MsMs 2291596 Specdb::MsMs 2291597 Specdb::MsMs 2643948 Specdb::MsMs 2643949 Specdb::MsMs 2643950 HMDB05023 #<Reference:0x000055ce3083a118> #<Reference:0x000055ce30839e48> #<Reference:0x000055ce30839bc8> 14-3-3 protein beta/alpha P31946 YWHAB 14-3-3 protein gamma P61981 YWHAG 14-3-3 protein zeta/delta P63104 YWHAZ Phosphoserine aminotransferase Q9Y617 PSAT1 Transaldolase P37837 TALDO1