1.0 2011-09-21 00:32:16 UTC 2015-10-09 22:33:06 UTC FDB023602 Ondansetron Ondansetron is a well tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drugs use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system; Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors; A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties; Ondansetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors. [HMDB] Ondansetron Zofran Zofran odt Zophren Zudan C18H19N3O 293.363 293.152812245 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one ondansetron 99614-02-5 CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2 InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 FELGMEQIXOGIFQ-UHFFFAOYSA-N belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring. Carbazoles Organic compounds Organoheterocyclic compounds Indoles and derivatives Carbazoles Aromatic heteropolycyclic compounds Aryl alkyl ketones Azacyclic compounds Benzenoids Heteroaromatic compounds Hydrocarbon derivatives Indoles N-alkylindoles N-methylpyrroles N-substituted imidazoles Organic oxides Organonitrogen compounds Organopnictogen compounds Vinylogous amides Aromatic heteropolycyclic compound Aryl alkyl ketone Aryl ketone Azacycle Azole Benzenoid Carbazole Heteroaromatic compound Hydrocarbon derivative Imidazole Indole Ketone N-alkylindole N-methylpyrrole N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyrrole Substituted pyrrole Vinylogous amide carbazoles Solid logp 2.56 ALOGPS logs -3.07 ALOGPS solubility 2.48e-01 g/l ALOGPS logp 2.35 ChemAxon pka_strongest_acidic 15.39 ChemAxon pka_strongest_basic 7.34 ChemAxon iupac 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one ChemAxon average_mass 293.363 ChemAxon mono_mass 293.152812245 ChemAxon smiles CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2 ChemAxon formula C18H19N3O ChemAxon inchi InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 ChemAxon inchikey FELGMEQIXOGIFQ-UHFFFAOYSA-N ChemAxon polar_surface_area 39.82 ChemAxon refractivity 86.78 ChemAxon polarizability 33.16 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 2021 Specdb::NmrTwoD 1956 Specdb::CMs 23367 Specdb::CMs 147166 Specdb::MsMs 89406 Specdb::MsMs 89407 Specdb::MsMs 89408 Specdb::MsMs 152334 Specdb::MsMs 152335 Specdb::MsMs 152336 Specdb::MsMs 451031 Specdb::MsMs 452363 Specdb::MsMs 2228064 Specdb::MsMs 2229005 Specdb::MsMs 2230456 Specdb::MsMs 2231438 Specdb::MsMs 2232745 Specdb::MsMs 2233870 Specdb::MsMs 2235087 Specdb::MsMs 2237306 Specdb::MsMs 2316419 Specdb::MsMs 2316420 Specdb::MsMs 2316421 Specdb::MsMs 2621783 Specdb::MsMs 2621784 Specdb::MsMs 2621785 HMDB05035 #<Reference:0x000055ce335c2db0> #<Reference:0x000055ce335c2bf8> 5-hydroxytryptamine receptor 3A P46098 HTR3A 5-hydroxytryptamine receptor 6 P50406 HTR6