1.0 2011-09-21 00:32:17 UTC 2015-07-21 06:57:47 UTC FDB023604 Sumatriptan Oftentimes, serotonin levels in the brain become extremely erratic before the onset of a migraine. In an attempt to stabilize this, sumatriptan is administered to help aid in leveling the serotonin levels in the brain. Sumatriptan is structurally similar to serotonin, and is a 5-HT (5-HT1D) agonist, which is one of the receptors that serotonin binds to. The specific receptor subtype it activates is present in the cranial and basilar arteries. Activation of these receptors causes vasoconstriction of those dilated arteries. Sumatriptan is also shown to decrease the activity of the trigeminal nerve.; Sumatriptan is a triptan drug including a sulfonamide group structurally similar to serotonin, and is a 5-HT (5-HT1D) agonist, which is one of the receptors that serotonin binds to. Oftentimes, serotonin levels in the brain become extremely erratic before the onset of a migraine. In an attempt to stabilize this, sumatriptan is administered to help aid in leveling the serotonin levels in the brain.; A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraines.; Sumatriptan (Imitrex, Imigran,Imigran Recovery ) is a triptan drug including a sulfonamide group which was originally developed by Glaxo for the treatment of migraine headaches. [HMDB] (3-[2-(dimethylamino)Ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide (3-[2-(dimethylamino)Ethyl]-1H-indol-5-yl)-N-methylmethanesulphonamide 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulphonamide 3-(2-(dimethylamino)Ethyl)-N-methyl-1H-indole-5-methanesulfonamide 3-(2-(dimethylamino)Ethyl)-N-methyl-1H-indole-5-methanesulphonamide 3-[2-(dimethylamino)Ethyl]-N-methylindole-5-methanesulfonamide 3-[2-(dimethylamino)Ethyl]-N-methylindole-5-methanesulphonamide Imigran Imigran Recovery Imitrex Sumatran Sumatriptan Sumatriptanum Sumax C14H21N3O2S 295.4 295.135447621 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide sumatriptan 103628-46-2 CNS(=O)(=O)CC1=CC2=C(NC=C2CCN(C)C)C=C1 InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 KQKPFRSPSRPDEB-UHFFFAOYSA-N belongs to the class of organic compounds known as tryptamines and derivatives. Tryptamines and derivatives are compounds containing the tryptamine backbone, which is structurally characterized by an indole ring substituted at the 3-position by an ethanamine. Tryptamines and derivatives Organic compounds Organoheterocyclic compounds Indoles and derivatives Tryptamines and derivatives Aromatic heteropolycyclic compounds 3-alkylindoles Aminosulfonyl compounds Aralkylamines Azacyclic compounds Benzenoids Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organic sulfonamides Organopnictogen compounds Organosulfonamides Substituted pyrroles Trialkylamines 3-alkylindole Amine Aminosulfonyl compound Aralkylamine Aromatic heteropolycyclic compound Azacycle Benzenoid Heteroaromatic compound Hydrocarbon derivative Indole Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid amide Organic sulfonic acid or derivatives Organonitrogen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Pyrrole Substituted pyrrole Sulfonyl Tertiary aliphatic amine Tertiary amine Tryptamine sulfonamide tryptamines Solid logp 1.17 ALOGPS logs -3.37 ALOGPS solubility 1.27e-01 g/l ALOGPS logp 0.74 ChemAxon pka_strongest_acidic 11.24 ChemAxon pka_strongest_basic 9.54 ChemAxon iupac 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide ChemAxon average_mass 295.4 ChemAxon mono_mass 295.135447621 ChemAxon smiles CNS(=O)(=O)CC1=CC2=C(NC=C2CCN(C)C)C=C1 ChemAxon formula C14H21N3O2S ChemAxon inchi InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 ChemAxon inchikey KQKPFRSPSRPDEB-UHFFFAOYSA-N ChemAxon polar_surface_area 65.2 ChemAxon refractivity 82.08 ChemAxon polarizability 32.31 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 417 Specdb::CMs 23533 Specdb::CMs 152288 Specdb::MsMs 107388 Specdb::MsMs 107389 Specdb::MsMs 107390 Specdb::MsMs 174360 Specdb::MsMs 174361 Specdb::MsMs 174362 Specdb::MsMs 374435 Specdb::MsMs 374826 Specdb::MsMs 451096 Specdb::MsMs 451526 Specdb::MsMs 2233568 Specdb::MsMs 2235349 Specdb::MsMs 2379255 Specdb::MsMs 2379256 Specdb::MsMs 2379257 Specdb::MsMs 2556642 Specdb::MsMs 2556643 Specdb::MsMs 2556644 HMDB05037 10650 #<Reference:0x000055ce333b9fa0> #<Reference:0x000055ce333b9de8> 5-hydroxytryptamine receptor 1B P28222 HTR1B 5-hydroxytryptamine receptor 1D P28221 HTR1D 5-hydroxytryptamine receptor 1F P30939 HTR1F Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 IKBKB