1.0 2011-09-21 00:34:30 UTC 2015-07-21 06:57:51 UTC FDB023772 Testosterone enanthate testosterone enanthate is used in androgen substitution to replace testosterone at levels as close to physiological levels as is possible. For some androgen-dependent functions testosterone is a pro-hormone, peripherally converted to 5alpha-dihydrotestosterone (DHT) and 17beta-estradiol (E2), of which the levels preferably should be within normal physiological ranges. Furthermore, androgens should have a good safety profile without adverse effects on the prostate, serum lipids, liver or respiratory function, and they must be convenient to use and patient-friendly, with a relative independence from medical services. Natural testosterone is viewed as the best androgen for substitution in hypogonadal men. testosterone enanthate is used to treat male hypogonadism. Male hypogonadism is one of the most common endocrinologic syndromes. The diagnosis is based on clinical signs and symptoms plus laboratory confirmation via the measurement of low morning testosterone levels on two different occasions. Serum luteinizing hormone and follicle-stimulating hormone levels distinguish between primary (hypergonadotropic) and secondary (hypogonadotropic) hypogonadism. Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism. In primary hypogonadal men the on bone mineral density (BMD) responds dose dependently to testosterone substitution, whereas in secondary hypogonadism only testosterone enanthate treatment significantly increased the BMD. In all mammalian species studied to date, testosterone has been found to be the predominant intratesticular steroid. In volunteers receiving hormonal contraception by using a combination of testosterone enanthate and levonorgestrel, there is a profound reduction of both intratesticular testosterone concentration and androgen bioactivity. High doses of testosterone enanthate can normalize hematocrit values of maintenance hemodialysis patients with replenished bone marrow iron stores. testosterone enanthate is classified as a prohibited substance by the World Anti-Doping Agency (WADA) and its use may be detected by way of the urinary testosterone/epitestosterone (T/E) ratio. (PMID: 16185098, 16467270, 15329035, 17530941, 17484401, 4028529, 12792150) [HMDB] 17-((1-Oxoheptyl)oxy)androst-4-en-3-one 17-Hydroxyandrost-4-en-3-one, 17-heptanoate 17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid 17b-Hydroxyandrost-4-en-3-one heptanoate 17b-Hydroxyandrost-4-en-3-one heptanoic acid 17beta-Enanthoxyandrost-4-en-3-one 17beta-Hydroxyandrost-4-en-3-one enanthate 17beta-Hydroxyandrost-4-en-3-one heptanoate 17beta-Hydroxyandrost-4-en-3-one heptanoic acid 17β-hydroxyandrost-4-en-3-one heptanoate 17β-hydroxyandrost-4-en-3-one heptanoic acid 4-Androsten-17beta-ol-3-one 17-enanthate 4-Androsten-3-one 17beta-enanthate Androgyn L.A. Andropository Androtardyl Atlatest DEA No. 4000 Delatest Delatestryl DePatestrye Depo-Testro Med Ditate Durathate Everone Exten test Malogen L.A. Malogen L.A.200 Orquisteron-E Primotestone Reposo TMD Testanthate Testate Testenate Testinon Testoenant Testonenant Testosterone 17-enanthate Testosterone 17-enanthic acid Testosterone 17beta-heptanoate Testosterone 17beta-heptanoic acid Testosterone enantate Testosterone heptanoate Testosterone heptanoic acid Testosterone heptoate Testosterone heptoic acid Testosterone heptylate Testosterone oenanthate Testostroval C26H40O3 400.594 400.297745146 (1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl heptanoate everone 315-37-7 [H][C@@]12CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C InChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1 VOCBWIIFXDYGNZ-IXKNJLPQSA-N belongs to the class of organic compounds known as steroid esters. Steroid esters are compounds containing a steroid moiety which bears a carboxylic acid ester group. Steroid esters Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroid esters Aliphatic homopolycyclic compounds 3-oxo delta-4-steroids Androgens and derivatives Carboxylic acid esters Cyclohexenones Delta-4-steroids Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides 3-oxo-delta-4-steroid 3-oxosteroid Aliphatic homopolycyclic compound Androgen-skeleton Androstane-skeleton Carbonyl group Carboxylic acid derivative Carboxylic acid ester Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Steroid ester C19 steroids (androgens) and derivatives C19 steroids (androgens) and derivatives enanthate ester sterol ester Solid logp 5.11 ALOGPS logs -5.94 ALOGPS solubility 4.63e-04 g/l ALOGPS logp 6.29 ChemAxon pka_strongest_acidic 19.09 ChemAxon pka_strongest_basic -4.8 ChemAxon iupac (1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl heptanoate ChemAxon average_mass 400.594 ChemAxon mono_mass 400.297745146 ChemAxon smiles [H][C@@]12CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon formula C26H40O3 ChemAxon inchi InChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-23-12-11-21-20-10-9-18-17-19(27)13-15-25(18,2)22(20)14-16-26(21,23)3/h17,20-23H,4-16H2,1-3H3/t20-,21-,22-,23-,25-,26-/m0/s1 ChemAxon inchikey VOCBWIIFXDYGNZ-IXKNJLPQSA-N ChemAxon polar_surface_area 43.37 ChemAxon refractivity 116.61 ChemAxon polarizability 49.2 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 10923 Specdb::CMs 138042 Specdb::CMs 145776 Specdb::MsMs 290053 Specdb::MsMs 290054 Specdb::MsMs 290055 Specdb::MsMs 329656 Specdb::MsMs 329657 Specdb::MsMs 329658 Specdb::MsMs 2703728 Specdb::MsMs 2703729 Specdb::MsMs 2703730 Specdb::MsMs 3001660 Specdb::MsMs 3001661 Specdb::MsMs 3001662 HMDB05814 #<Reference:0x000055ce32b6c6b8> #<Reference:0x000055ce32b6c4d8> #<Reference:0x000055ce32b6c320> #<Reference:0x000055ce32b6c0c8> #<Reference:0x000055ce32b67f00> #<Reference:0x000055ce32b67c58> #<Reference:0x000055ce32b679b0>