Record Information
Version1.0
Creation date2011-09-21 00:34:58 UTC
Update date2015-07-21 06:57:52 UTC
Primary IDFDB023805
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameNorbolethone
DescriptionNorbolethone is a 19-nor anabolic steroid first synthesized in 1966. During the 1960s it was administered to humans in efficacy studies concerned with short stature and underweight conditions. It has never been reported by doping control laboratories prior to 2001. Norbolethone was identified in two urine samples from one athlete by matching the mass spectra and chromatographic retention times with those of a reference standard. The samples also contained at least one likely metabolite. The samples were also unusual because the concentrations of endogenous steroids were exceptionally low. Since norbolethone is not known to be marketed by any pharmaceutical company, a clandestine source of norbolethone may exist. Norbolethone matches the description for what is described as a "designer steroid." Androgenic anabolic steroids (AAS) are defined as natural, synthetic or semi-synthetic drugs chemicals derived from testosterone, used with the aim to improve physical performance by increasing both muscle strength and mass. Despite their reported toxicological effects on the cardiovascular, hepatic and neuro-endocrine systems, the AAS have been extensively used in sports activities. (PMID: 12112254) [HMDB]
CAS Number1235-15-0
Structure
Thumb
Synonyms
SynonymSource
13-EHDPOMeSH
13-Ethyl-17-hydroxy-18,19-dinor-17-pregn-4-en-20-yn-3-oneMeSH
NorboletoneChEMBL, HMDB
(+/-)-13,17a-diethyl-17b-hydroxygon-4-en-3-oneHMDB
(+/-)-13-ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-3-oneHMDB
(+/-)-13b,17a-diethyl-17b-hydroxygon-4-en-3-oneHMDB
(+/-)-17a-ethyl-18-homo-19-nortestosteroneHMDB
(17a)-(+/-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-3-oneHMDB
13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-3-oneHMDB
DL-13,17a-Diethyl-17-hydroxygon-4-en-3-oneHMDB
DL-13,17a-Diethyl-17b-hydroxygon-4-en-3-oneHMDB
DL-17b-Hydroxy-13b,17a-diethylgon-4-en-3-oneHMDB
DL-NorbolethoneHMDB
GenabolHMDB
Wy 3475HMDB
(+/-)-13-ethyl-17-hydroxy-18,19-Dinor-17a-pregn-4-en-3-onehmdb
(+/-)-13,17a-Diethyl-17b-hydroxygon-4-en-3-onehmdb
(+/-)-13b,17a-Diethyl-17b-hydroxygon-4-en-3-onehmdb
(+/-)-17a-Ethyl-18-homo-19-nortestosteronehmdb
(17a)-(+/-)-13-ethyl-17-hydroxy-18,19-Dinorpregn-4-en-3-onehmdb
13-ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-3-onehmdb
dl-13,17a-Diethyl-17-hydroxygon-4-en-3-onehmdb
dl-17b-Hydroxy-13b,17a-diethylgon-4-en-3-onehmdb
Predicted Properties
PropertyValueSource
Water Solubility0.0098 g/LALOGPS
logP4.02ALOGPS
logP4.31ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)19.28ChemAxon
pKa (Strongest Basic)-0.13ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity93.72 m³·mol⁻¹ChemAxon
Polarizability38.16 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC21H32O2
IUPAC name(1S,2R,10R,11S,14S,15S)-14,15-diethyl-14-hydroxytetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
InChI IdentifierInChI=1S/C21H32O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h13,16-19,23H,3-12H2,1-2H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChI KeyFTBJKONNNSKOLX-XUDSTZEESA-N
Isomeric SMILES[H][C@@]12CC[C@@](O)(CC)[C@@]1(CC)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
Average Molecular Weight316.4776
Monoisotopic Molecular Weight316.240230268
Classification
Description Belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassPregnane steroids
Direct ParentGluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • 17-hydroxysteroid
  • Oxosteroid
  • Hydroxysteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Cyclic alcohol
  • Tertiary alcohol
  • Cyclic ketone
  • Ketone
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Alcohol
  • Organooxygen compound
  • Organic oxide
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Process

Naturally occurring process:

Role

Biological role:

Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSNorbolethone, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-000i-1291000000-d413aaf2b4edf2000360Spectrum
Predicted GC-MSNorbolethone, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0c00-1119000000-352ad6792758ae9d94d7Spectrum
Predicted GC-MSNorbolethone, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00kb-0095000000-cda25eaf9c10361b9222Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-0191000000-7aa90a3e0c0842920d99Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-05di-1690000000-4a138059002b023720e8Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0029000000-98b78b3afa508c81ab7bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-014i-0069000000-9be5f2e135e6a2d1b47dSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-052s-0090000000-810ee3872d7cdf37d1e0Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0009000000-be6e06313d0abca8e664Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-014i-0019000000-eb65f94e6914722e1b9cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-014i-0092000000-3816ecdb5ba24754d396Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00kb-0096000000-12094c8bb5dfd35602b9Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-01ba-0791000000-6a375c28af2bcbf46d2bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0691-1900000000-118c6246477fc37b89c4Spectrum
NMRNot Available
ChemSpider ID59638
ChEMBL IDCHEMBL2105134
KEGG Compound IDD05204
Pubchem Compound ID66255
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB06026
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNorbolethone
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference