1.0 2011-09-21 00:36:46 UTC 2015-07-21 06:57:56 UTC FDB023912 Selenophosphate Selenophosphate is the universal selenium donor that is required for the formation of selenium dependent enzymes and selenium tRNAs (i.e.: selenocysteyl-tRNA). Selenophosphate is also the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Selenophosphate synthetase (EC 2.7.9.3, human SPS1, product of the selD gene) produces monoselenophosphate from selenide and ATP. The SPS1-encoded enzyme depends on a selenium salvage system that recycles L-selenocysteine. Selenophosphate synthetase genes play a role in cancer cell's response to ionizing radiation and its reaction product, selenophosphate, might be involved in cancer prevention in a p53-dependent manner and could be applied to development of a novel cancer therapy. (PMID: 8986768, 10609888, 16786570) [HMDB] Dihydroxy-oxido-selanylideneorane dihydroxy-oxido-selanylidenephosphorane Orus monoselenide Orus selenide (pse) Phosphorus monoselenide Phosphorus selenide (PSe) Selenoxo-ino selenoxo-phosphino H2O3PSe 159.95 160.89067727 hydrogen hydroxy(selanylidene)phosphonite hydrogen hydroxy(selanylidene)phosphonite 289702-60-9 OP(O)([O-])=[Se] InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5)/p-1 JRPHGDYSKGJTKZ-UHFFFAOYSA-M belongs to the class of inorganic compounds known as non-metal phosphonates. These are inorganic non-metallic compounds containing a phosphonate as its largest oxoanion. Non-metal phosphonates Inorganic compounds Homogeneous non-metal compounds Non-metal oxoanionic compounds Non-metal phosphonates Inorganic oxides Inorganic oxide Non-metal phosphonate Solid logp -1.1 ChemAxon pka_strongest_acidic -6.3 ChemAxon iupac hydrogen hydroxy(selanylidene)phosphonite ChemAxon average_mass 159.95 ChemAxon mono_mass 160.89067727 ChemAxon smiles OP(O)([O-])=[Se] ChemAxon formula H2O3PSe ChemAxon inchi InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5)/p-1 ChemAxon inchikey JRPHGDYSKGJTKZ-UHFFFAOYSA-M ChemAxon polar_surface_area 63.52 ChemAxon refractivity 25.2 ChemAxon polarizability 6.87 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -3 ChemAxon formal_charge -1 ChemAxon Selenoamino Acid Metabolism SMP00029 map00450 Specdb::MsMs 27590 Specdb::MsMs 27591 Specdb::MsMs 27592 Specdb::MsMs 34148 Specdb::MsMs 34149 Specdb::MsMs 34150 HMDB06407 #<Reference:0x000055ce31f8bb28> #<Reference:0x000055ce31f8b970> #<Reference:0x000055ce31f8b7b8> O-phosphoseryl-tRNA(Sec) selenium transferase Q9HD40 SEPSECS Selenide, water dikinase 1 P49903 SEPHS1 Selenide, water dikinase 2 Q99611 SEPHS2