1.0 2011-09-21 00:37:43 UTC 2015-07-21 06:57:57 UTC FDB023967 Debrisoquine Debrisoquine is an adrenergic neuron-blocking drug. Genetic and environmental factors are determinants of the interindividual and interethnic variability in drug metabolism. Thus, interethnic differences in debrisoquine hydroxylation polymorphism (Cytochrome p450, subfamily IID, polypeptide 6, CYP2D6) might be partly responsible for the variation in haloperidol disposition between races. The influence of tobacco, ethanol, caffeine, gender, and oral contraceptive use on the debrisoquine metabolic ratio (MR) has been analyzed in panels of healthy volunteers. About 5-10% of European white population has a genetically determinant defect of the CYP2D6, one of the enzymes of cytochrome P-450. This defect leads to the impaired metabolism of many drugs including various psychopharmacological agents. The measurement of the hydroxylation of debrisoquine is a laboratory test which allows identifying such an individual. Patients who show an impaired hydroxylation of debrisoquine usually demonstrate severe side effects and poor outcome of psychopharmacotherapy. In practice, knowledge of a patient's debrisoquine metabolic phenotype is an advantage when prescribing tricyclic antidepressants and neuroleptics, as the drug concentration will be considerably higher in slow metabolisers than in the average patient. (PMID: 8839686, 1738265, 7878155) [HMDB] 3,4-dihydro-2(1H)-isoquinolinecarboximidamide Debrisochinum Debrisoquin debrisoquin sulfate Debrisoquin sulphate Debrisoquina Debrisoquinum Isocaramidine C10H13N3 175.2303 175.110947431 1,2,3,4-tetrahydroisoquinoline-2-carboximidamide debrisoquin 1131-64-2 NC(=N)N1CCC2=CC=CC=C2C1 InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) JWPGJSVJDAJRLW-UHFFFAOYSA-N belongs to the class of organic compounds known as tetrahydroisoquinolines. These are tetrahydrogenated isoquinoline derivatives. Tetrahydroisoquinolines Organic compounds Organoheterocyclic compounds Tetrahydroisoquinolines Aromatic heteropolycyclic compounds Azacyclic compounds Benzenoids Carboximidamides Guanidines Hydrocarbon derivatives Imines Organopnictogen compounds Aromatic heteropolycyclic compound Azacycle Benzenoid Carboximidamide Guanidine Hydrocarbon derivative Imine Organic nitrogen compound Organonitrogen compound Organopnictogen compound Tetrahydroisoquinoline carboxamidine isoquinolines Solid logp 0.58 ALOGPS logs -2.32 ALOGPS solubility 8.42e-01 g/l ALOGPS logp 1.07 ChemAxon pka_strongest_basic 12.47 ChemAxon iupac 1,2,3,4-tetrahydroisoquinoline-2-carboximidamide ChemAxon average_mass 175.2303 ChemAxon mono_mass 175.110947431 ChemAxon smiles NC(=N)N1CCC2=CC=CC=C2C1 ChemAxon formula C10H13N3 ChemAxon inchi InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) ChemAxon inchikey JWPGJSVJDAJRLW-UHFFFAOYSA-N ChemAxon polar_surface_area 53.11 ChemAxon refractivity 63.85 ChemAxon polarizability 19.48 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 6851 Specdb::CMs 151818 Specdb::MsIr 2415 Specdb::MsIr 2416 Specdb::MsIr 2417 Specdb::MsMs 250140 Specdb::MsMs 250141 Specdb::MsMs 250142 Specdb::MsMs 270078 Specdb::MsMs 270079 Specdb::MsMs 270080 Specdb::MsMs 2703617 Specdb::MsMs 2703618 Specdb::MsMs 2703619 Specdb::MsMs 3001420 Specdb::MsMs 3001421 Specdb::MsMs 3001422 HMDB06543 #<Reference:0x000055ce33433080> #<Reference:0x000055ce33432ec8> #<Reference:0x000055ce33432d10> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823