1.0 2011-09-21 01:26:33 UTC 2025-11-19 02:53:18 UTC FDB027561 Resolvin E1 Resolvin E1 is a resolvin, a bioactive oxygenated product of EPA (eicosapentaenoic acid). It is a inflammation-resolving lipid mediator. RvE1 reduces neutrophil hyper-function, it also prevents the initiation and progression of tissue destruction (PMID: 16373400). RvE1, can also act as a host response modulator in the control of the inflammatory diseases that also involve bone loss such as periodontitis and arthritis. RvE1 has been shown to display specific binding sites on human neutrophils with an apparent Kd of 47 nM (PMID: 15753205; 16373400). RvE1 is a potent modulator of leukocytes as well as selective platelet responses in blood and platelet-rich plasma (PMID: 18480426). [HMDB] 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA resolvin E1 resolvinE1 RvE1 C20H30O5 350.4492 350.20932407 5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid 5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid CCC(O)C=CC=CCC(O)C=CC=CC=CC(O)CCCC(O)=O InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25) AOPOCGPBAIARAV-UHFFFAOYSA-N belongs to the class of organic compounds known as hydroxyeicosapentaenoic acids. These are eicosanoic acids with an attached hydroxyl group and five CC double bonds. Hydroxyeicosapentaenoic acids Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic acyclic compounds Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Hydroxy fatty acids Long-chain fatty acids Monocarboxylic acids and derivatives Organic oxides Polyols Secondary alcohols Unsaturated fatty acids Alcohol Aliphatic acyclic compound Carbonyl group Carboxylic acid Carboxylic acid derivative Fatty acid Hydrocarbon derivative Hydroxy fatty acid Hydroxyeicosapentaenoic acid Long-chain fatty acid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Polyol Secondary alcohol Unsaturated fatty acid Solid logp 4.24 ALOGPS logs -3.89 ALOGPS solubility 4.50e-02 g/l ALOGPS logp 2.53 ChemAxon pka_strongest_acidic 4.65 ChemAxon pka_strongest_basic -1.1 ChemAxon iupac 5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid ChemAxon average_mass 350.4492 ChemAxon mono_mass 350.20932407 ChemAxon smiles CCC(O)C=CC=CCC(O)C=CC=CC=CC(O)CCCC(O)=O ChemAxon formula C20H30O5 ChemAxon inchi InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25) ChemAxon inchikey AOPOCGPBAIARAV-UHFFFAOYSA-N ChemAxon polar_surface_area 97.99 ChemAxon refractivity 105.62 ChemAxon polarizability 41.82 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 5 ChemAxon donor_count 4 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 112779 Specdb::CMs 126333 Specdb::CMs 970593 Specdb::CMs 970594 Specdb::CMs 970595 Specdb::CMs 970596 Specdb::CMs 970597 Specdb::CMs 970598 Specdb::CMs 970599 Specdb::CMs 970600 Specdb::CMs 970601 Specdb::CMs 970602 Specdb::CMs 970603 Specdb::CMs 970604 Specdb::CMs 970605 Specdb::CMs 970606 Specdb::CMs 970607 Specdb::CMs 970608 Specdb::CMs 970609 Specdb::CMs 970610 Specdb::CMs 970611 Specdb::CMs 970612 Specdb::CMs 970613 Specdb::CMs 970614 Specdb::CMs 970615 HMDB10410 #<Reference:0x000055ce32d46560> #<Reference:0x000055ce32d463a8> #<Reference:0x000055ce32d461c8> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823