1.0 2011-09-21 01:38:12 UTC 2018-05-28 18:38:10 UTC FDB028337 Uridine 2',3'-cyclic phosphate Uridine 2',3'-cyclic phosphate is a cyclic nucleotide. A cyclic nucleotide is any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. Cyclic phosphates are commonly found at the 3' end of mRNAs and other small RNAs. Uridine 2',3'-cyclic phosphate is a substrate for the enzyme 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase, EC 3.1.4.37) which hydrolyses it to Uridine 2'-phosphate. CNPase is a unique RNase in that it only cleaves nucleoside 2',3'-cyclic phosphates and not the RNA internucleotide linkage, like other RNases such as RNase A and RNase T1. [HMDB] 1-(2,3-O-Inico-a-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione 1-(2,3-O-Inico-alpha-delta-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione 1-(2,3-O-phosphinico-a-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione 1-(2,3-O-phosphinico-alpha-delta-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione 2',3'-cUMP 2',3'-Cyclic UMP CUMP Uridine 2',3'-cyclic monoate Uridine 2',3'-cyclic monophosphate Uridine 2',3'-cycloate Uridine 2',3'-cycloic acid Uridine, cyclic 2',3'-(hydrogen ate) Uridine, cyclic 2',3'-(hydrogen ic acid) C9H11N2O8P 306.166 306.02530185 1-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione 2',3'-cyclic ump 40632-52-8 OC[C@H]1O[C@H]([C@@H]2OP(O)(=O)O[C@H]12)N1C=CC(=O)NC1=O InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/t4-,6-,7-,8-/m1/s1 HWDMHJDYMFRXOX-XVFCMESISA-N belongs to the class of organic compounds known as 2',3'-cyclic pyrimidine nucleotides. These are pyrimidine nucleotides in which the oxygen atoms linked to the C2 and C3 carbon atoms of the ribose moiety are both bonded the same phosphorus atom of the phosphate group. 2',3'-cyclic pyrimidine nucleotides Organic compounds Nucleosides, nucleotides, and analogues Pyrimidine nucleotides Cyclic pyrimidine nucleotides Aromatic heteropolycyclic compounds Azacyclic compounds Dioxaphospholanes Heteroaromatic compounds Hydrocarbon derivatives Hydropyrimidines Lactams Monosaccharides Organic oxides Organic phosphoric acids and derivatives Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Primary alcohols Pyrimidones Ribonucleoside 3'-phosphates Tetrahydrofurans Ureas Vinylogous amides 1,3_dioxaphospholane 2',3'-cyclic pyrimidine ribonucleotide Alcohol Aromatic heteropolycyclic compound Azacycle Heteroaromatic compound Hydrocarbon derivative Hydropyrimidine Lactam Monosaccharide Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Primary alcohol Pyrimidine Pyrimidone Ribonucleoside 3'-phosphate Tetrahydrofuran Urea Vinylogous amide 2',3'-Cyclic nucleotides 2',3'-cyclic pyrimidine nucleotide Solid logp -1.30 ALOGPS logs -1.17 ALOGPS solubility 2.08e+01 g/l ALOGPS logp -1.6 ChemAxon pka_strongest_acidic 1.76 ChemAxon pka_strongest_basic -3 ChemAxon iupac 1-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione ChemAxon average_mass 306.166 ChemAxon mono_mass 306.02530185 ChemAxon smiles OC[C@H]1O[C@H]([C@@H]2OP(O)(=O)O[C@H]12)N1C=CC(=O)NC1=O ChemAxon formula C9H11N2O8P ChemAxon inchi InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/t4-,6-,7-,8-/m1/s1 ChemAxon inchikey HWDMHJDYMFRXOX-XVFCMESISA-N ChemAxon polar_surface_area 134.63 ChemAxon refractivity 59.66 ChemAxon polarizability 24.7 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 17324 Specdb::CMs 39736 Specdb::CMs 149191 Specdb::MsMs 23126 Specdb::MsMs 23127 Specdb::MsMs 23128 Specdb::MsMs 29924 Specdb::MsMs 29925 Specdb::MsMs 29926 Specdb::MsMs 2813501 Specdb::MsMs 2813502 Specdb::MsMs 2813503 Specdb::MsMs 2891550 Specdb::MsMs 2891551 Specdb::MsMs 2891552 Specdb::NmrOneD 93752 Specdb::NmrOneD 93753 Specdb::NmrOneD 93754 Specdb::NmrOneD 93755 Specdb::NmrOneD 93756 Specdb::NmrOneD 93757 Specdb::NmrOneD 93758 Specdb::NmrOneD 93759 Specdb::NmrOneD 93760 Specdb::NmrOneD 93761 Specdb::NmrOneD 93762 Specdb::NmrOneD 93763 Specdb::NmrOneD 93764 Specdb::NmrOneD 93765 Specdb::NmrOneD 93766 Specdb::NmrOneD 93767 Specdb::NmrOneD 93768 Specdb::NmrOneD 93769 Specdb::NmrOneD 93770 Specdb::NmrOneD 93771 HMDB11640 Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 2',3'-cyclic-nucleotide 3'-phosphodiesterase P09543 CNP