1.0 2011-09-21 01:38:41 UTC 2015-07-21 06:59:23 UTC FDB028368 Inosine 2',3'-cyclic phosphate Inosine-2′,3′-cyclic phosphate is a cyclic nucleotide. A cyclic nucleotide is any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. 2',3' cyclic IMP is a substrate for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37). This enzyme (also called CNP) catalyzes the chemical reaction: nucleoside 2',3'-cyclic phosphate + H2O <-> nucleoside 2'-phosphate. CNP is a myelin-associated enzyme that makes up 4% of total CNS myelin protein, and is thought to undergo significant age-associated changes. The absence of CNP causes axonal swelling and neuronal degeneration. The biological role of cyclic 2',3' monophosphates is not clear, although it is thought to have something to do with neuronal stasis or development. [HMDB] 2',3' cyclic IMP Inosine cyclic 2,3 monoate Inosine cyclic 2,3 monophosphate Inosine cyclic 2',3'-(hydrogen ate) Inosine cyclic 2',3'-(hydrogen phosphate) Inosine cyclic 2',3'-monoate Inosine cyclic 2',3'-monophosphate Inosine cyclic-2',3'-monoate Inosine cyclic-2',3'-monophosphate C10H11N4O7P 330.1907 330.036535238 9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-6,9-dihydro-3H-purin-6-one 9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-3H-purin-6-one 15569-30-9 OC[C@H]1O[C@H]([C@@H]2OP(O)(=O)O[C@H]12)N1C=NC2=C1NC=NC2=O InChI=1S/C10H11N4O7P/c15-1-4-6-7(21-22(17,18)20-6)10(19-4)14-3-13-5-8(14)11-2-12-9(5)16/h2-4,6-7,10,15H,1H2,(H,17,18)(H,11,12,16)/t4-,6-,7-,10-/m1/s1 SBJVDTBACUMFFD-KQYNXXCUSA-N belongs to the class of organic compounds known as 2',3'-cyclic purine nucleotides. These are purine nucleotides in which the oxygen atoms linked to the C2 and C3 carbon atoms of the ribose moiety are both bonded the same phosphorus atom of the phosphate group. 2',3'-cyclic purine nucleotides Organic compounds Nucleosides, nucleotides, and analogues Purine nucleotides Cyclic purine nucleotides Aromatic heteropolycyclic compounds 6-oxopurines Azacyclic compounds Dioxaphospholanes Heteroaromatic compounds Hydrocarbon derivatives Hypoxanthines Monosaccharides N-substituted imidazoles Organic oxides Organic phosphoric acids and derivatives Organonitrogen compounds Organopnictogen compounds Oxacyclic compounds Primary alcohols Pyrimidones Ribonucleoside 3'-phosphates Tetrahydrofurans Vinylogous amides 1,3_dioxaphospholane 2',3'-cyclic purine ribonucleotide 6-oxopurine Alcohol Aromatic heteropolycyclic compound Azacycle Azole Heteroaromatic compound Hydrocarbon derivative Hypoxanthine Imidazole Imidazopyrimidine Monosaccharide N-substituted imidazole Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Oxacycle Primary alcohol Purine Purinone Pyrimidine Pyrimidone Ribonucleoside 3'-phosphate Tetrahydrofuran Vinylogous amide Solid logp -1.12 ALOGPS logs -2.09 ALOGPS solubility 2.71e+00 g/l ALOGPS logp -2.2 ChemAxon pka_strongest_acidic 1.72 ChemAxon pka_strongest_basic 2.78 ChemAxon iupac 9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-6,9-dihydro-3H-purin-6-one ChemAxon average_mass 330.1907 ChemAxon mono_mass 330.036535238 ChemAxon smiles OC[C@H]1O[C@H]([C@@H]2OP(O)(=O)O[C@H]12)N1C=NC2=C1NC=NC2=O ChemAxon formula C10H11N4O7P ChemAxon inchi InChI=1S/C10H11N4O7P/c15-1-4-6-7(21-22(17,18)20-6)10(19-4)14-3-13-5-8(14)11-2-12-9(5)16/h2-4,6-7,10,15H,1H2,(H,17,18)(H,11,12,16)/t4-,6-,7-,10-/m1/s1 ChemAxon inchikey SBJVDTBACUMFFD-KQYNXXCUSA-N ChemAxon polar_surface_area 144.5 ChemAxon refractivity 67.99 ChemAxon polarizability 27.57 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 8 ChemAxon donor_count 3 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 11638 Specdb::CMs 39762 Specdb::CMs 136594 Specdb::CMs 144328 Specdb::MsMs 291688 Specdb::MsMs 291689 Specdb::MsMs 291690 Specdb::MsMs 331666 Specdb::MsMs 331667 Specdb::MsMs 331668 Specdb::MsMs 2695269 Specdb::MsMs 2695270 Specdb::MsMs 2695271 Specdb::MsMs 2986519 Specdb::MsMs 2986520 Specdb::MsMs 2986521 Specdb::NmrOneD 93932 Specdb::NmrOneD 93933 Specdb::NmrOneD 93934 Specdb::NmrOneD 93935 Specdb::NmrOneD 93936 Specdb::NmrOneD 93937 Specdb::NmrOneD 93938 Specdb::NmrOneD 93939 Specdb::NmrOneD 93940 Specdb::NmrOneD 93941 Specdb::NmrOneD 93942 Specdb::NmrOneD 93943 Specdb::NmrOneD 93944 Specdb::NmrOneD 93945 Specdb::NmrOneD 93946 Specdb::NmrOneD 93947 Specdb::NmrOneD 93948 Specdb::NmrOneD 93949 Specdb::NmrOneD 93950 Specdb::NmrOneD 93951 HMDB11680 Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 2',3'-cyclic-nucleotide 3'-phosphodiesterase P09543 CNP