Record Information
Version1.0
Creation date2011-09-21 01:39:24 UTC
Update date2019-11-26 03:21:28 UTC
Primary IDFDB028413
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameGlycyl-glycine
DescriptionThe simplest peptide, made of two glycine molecules; used in the synthesis of more complicated peptides. Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895) [HMDB]
CAS Number556-50-3
Structure
Thumb
Synonyms
SynonymSource
2-(Aminoacetamido)acetic acidChEBI
[(Aminoacetyl)amino]acetic acidChEBI
Gly-glyChEBI
Gly2ChEBI
Glycine dipeptideChEBI
N-GlycylglycineChEBI
2-(Aminoacetamido)acetateGenerator
[(Aminoacetyl)amino]acetateGenerator
((Aminoacetyl)amino)acetic acidHMDB
alpha-GlycylglycineHMDB
DiglycineHMDB
N-GLYCYL- glycineHMDB
Glycylglycine hydrochlorideHMDB
Glycyl glycineHMDB
Glycylglycine monohydrochlorideHMDB
Hydrochloride, glycylglycineHMDB
Monohydrochloride, glycylglycineHMDB
N GlycylglycineHMDB
Glycyl-glycineMeSH
((aminoacetyl)amino)acetic acidhmdb
[(aminoacetyl)amino]acetic acidhmdb
alpha-glycylglycinehmdb
Diglycine (van)hmdb
GlycylglycineChEBI
n-GLYCYL- Glycinehmdb
N-glycylglycinehmdb
Predicted Properties
PropertyValueSource
Water Solubility82.1 g/LALOGPS
logP-3.2ALOGPS
logP-4.5ChemAxon
logS-0.21ALOGPS
pKa (Strongest Acidic)3.52ChemAxon
pKa (Strongest Basic)8.14ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.42 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity28.81 m³·mol⁻¹ChemAxon
Polarizability12.01 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC4H8N2O3
IUPAC name2-(2-aminoacetamido)acetic acid
InChI IdentifierInChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
InChI KeyYMAWOPBAYDPSLA-UHFFFAOYSA-N
Isomeric SMILESNCC(=O)NCC(O)=O
Average Molecular Weight132.1179
Monoisotopic Molecular Weight132.053492132
Classification
Description Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentDipeptides
Alternative Parents
Substituents
  • Alpha-dipeptide
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Alpha-amino acid or derivatives
  • Amino acid or derivatives
  • Carboxamide group
  • Amino acid
  • Secondary carboxylic acid amide
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Primary aliphatic amine
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organopnictogen compound
  • Amine
  • Organic oxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location:

Source:

Process

Naturally occurring process:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSGlycyl-glycine, 4 TMS, GC-MS Spectrumsplash10-00di-2910000000-ba948ec1f3049dba6890Spectrum
GC-MSGlycyl-glycine, 3 TMS, GC-MS Spectrumsplash10-00di-2900000000-91132b8ff819b3ae47dcSpectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-001i-9000000000-e81c9e2483d01587c1bdSpectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-001i-9000000000-156d6e678bff48157df2Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-4cc7d622d8302ea78998Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-1910000000-4b3d1fa3d216c551cb12Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-588aa5f9b282e25fb005Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-9700000000-de41939f179394ca4fd9Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-9800000000-6a5f2500f08c12371f1fSpectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-2910000000-ba948ec1f3049dba6890Spectrum
GC-MSGlycyl-glycine, non-derivatized, GC-MS Spectrumsplash10-00di-2900000000-91132b8ff819b3ae47dcSpectrum
Predicted GC-MSGlycyl-glycine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a59-9000000000-8abf1a0641d024ca8310Spectrum
Predicted GC-MSGlycyl-glycine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-05a9-9100000000-7a4991aa2e80bb0b6709Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-0900000000-ed69bb1a3dbb10d0d5e8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00dr-9100000000-d1fb7ab0c1ba8cc65835Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00di-9000000000-7ba83a3b96d2fc869ebeSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-00di-9000000000-6173af951359b504bcd8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0006-9000000000-939e8bb535cf95146346Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-008i-9800000000-bda55e81f5401b1bf95fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-003r-6900000000-086c493e2bef9931c65eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-004i-9000000000-6446e10ba29e02e8889dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-004i-9000000000-414da3e4ba078845db83Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-004i-9000000000-838fb02e1a4a51356aacSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-01b9-9000000000-2dce65916bdcc5799b7bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-001i-0900000000-7bab12a2074040375089Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9500000000-5bb432a63f09472025a8Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00gi-9000000000-985944270c18616f5da3Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-05e9-9000000000-4ad263a0b78114d654fdSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-4900000000-c1e049bc22bd20fc2b12Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0089-9500000000-1039b99bd3cc506dcfdbSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0abc-9100000000-1cf10876a736a8090b01Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
ChemSpider ID10690
ChEMBL IDCHEMBL292467
KEGG Compound IDC02037
Pubchem Compound ID11163
Pubchem Substance IDNot Available
ChEBI ID17201
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB11733
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference