1.02011-09-21 01:45:07 UTC2015-07-21 06:59:32 UTCFDB028799(R)-2,3-Dihydroxy-isovalerate(R) 2,3-Dihydroxy-isovalerate is an intermediate in valine, leucine and isoleucine biosynthesis. The pathway of valine biosynthesis is a four-step pathway that shares all of its steps with the parallel pathway of isoleucine biosynthesis. These entwined pathways are part of the superpathway of leucine, valine, and isoleucine biosynthesis , that generates not only isoleucine and valine, but also leucine. (R) 2,3-Dihydroxy-isovalerate is generated from 3-Hydroxy-3-methyl-2-oxobutanoic acid via the enzyme ketol-acid reductoisomerase (EC 1.1.1.86) then it is converted to 2-Oxoisovalerate via the dihydroxy-acid dehydratase (EC:4.2.1.9). [HMDB](2R)-2,3-dihydroxy-3-methylbutanoate(2R)-2,3-dihydroxy-3-methylbutanoic acid(R)-2,3-dihydroxy-3-methylbutanoate(R)-2,3-dihydroxy-3-methylbutanoic acid(R)-2,3-Dihydroxy-isovaleric acidC5H10O4134.1305134.057908808(2R)-2,3-dihydroxy-3-methylbutanoic acid(R)-2,3-dihydroxy-isovalerateCC(C)(O)[C@@H](O)C(O)=OInChI=1S/C5H10O4/c1-5(2,9)3(6)4(7)8/h3,6,9H,1-2H3,(H,7,8)/t3-/m0/s1JTEYKUFKXGDTEU-VKHMYHEASA-N belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group.Hydroxy fatty acidsOrganic compoundsLipids and lipid-like moleculesFatty AcylsFatty acids and conjugatesAliphatic acyclic compounds1,2-diolsAlpha hydroxy acids and derivativesCarbonyl compoundsCarboxylic acidsHydrocarbon derivativesMethyl-branched fatty acidsMonocarboxylic acids and derivativesMonosaccharidesOrganic oxidesSecondary alcoholsShort-chain hydroxy acids and derivativesTertiary alcohols1,2-diolAlcoholAliphatic acyclic compoundAlpha-hydroxy acidBranched fatty acidCarbonyl groupCarboxylic acidCarboxylic acid derivativeHydrocarbon derivativeHydroxy acidHydroxy fatty acidMethyl-branched fatty acidMonocarboxylic acid or derivativesMonosaccharideOrganic oxideOrganic oxygen compoundOrganooxygen compoundSecondary alcoholShort-chain hydroxy acidTertiary alcohol2,3-dihydroxy-3-methylbutanoic acidSolidlogp-0.83logs0.60solubility5.29e+02 g/llogp-0.82pka_strongest_acidic3.8pka_strongest_basic-3.2iupac(2R)-2,3-dihydroxy-3-methylbutanoic acidaverage_mass134.1305mono_mass134.057908808smilesCC(C)(O)[C@@H](O)C(O)=OformulaC5H10O4inchiInChI=1S/C5H10O4/c1-5(2,9)3(6)4(7)8/h3,6,9H,1-2H3,(H,7,8)/t3-/m0/s1inchikeyJTEYKUFKXGDTEU-VKHMYHEASA-Npolar_surface_area77.76refractivity29.44polarizability12.48rotatable_bond_count2acceptor_count4donor_count3physiological_charge-1formal_charge0Specdb::CMs3242Specdb::CMs39827Specdb::CMs160651Specdb::MsIr2657Specdb::MsIr2658Specdb::MsIr2659Specdb::NmrOneD151250Specdb::NmrOneD151251Specdb::NmrOneD151252Specdb::NmrOneD151253Specdb::NmrOneD151254Specdb::NmrOneD151255Specdb::NmrOneD151256Specdb::NmrOneD151257Specdb::NmrOneD151258Specdb::NmrOneD151259Specdb::NmrOneD151260Specdb::NmrOneD151261Specdb::NmrOneD151262Specdb::NmrOneD151263Specdb::NmrOneD151264Specdb::NmrOneD151265Specdb::NmrOneD151266Specdb::NmrOneD151267Specdb::NmrOneD151268Specdb::NmrOneD151269Specdb::MsMs23120Specdb::MsMs23121Specdb::MsMs23122Specdb::MsMs29918Specdb::MsMs29919Specdb::MsMs29920Specdb::MsMs2380829Specdb::MsMs2380830Specdb::MsMs2380831Specdb::MsMs2558124Specdb::MsMs2558125Specdb::MsMs2558126HMDB1214115684AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823