1.0 2011-09-21 01:46:21 UTC 2015-07-21 06:59:33 UTC FDB028860 Dimethylarsinous acid Dimethylarsinous acid is a reactive organic intermediate of dimethylarsinic acid involved in toxicity. Dimethylarsinous acid is detected in the urine of individuals who ingest arsenic-polluted drinking water. The cytogenetic study in V79 cells using iododimethylarsine, which is easily hydrolyzed to dimethylarsinous acid in water, revealed that dimethylarsinous acid was very cytotoxic (50% growth inhibition concentration; 1.1 (+-) 0.14 uM), and either induced aneuploids or a high rate of tetraploids (73% at 2.5 &#956;M). Dimethylarsinous acid caused mitotic arrest, since the mitotic index at toxic dose (5 &#956;M) was 13.9%, significantly higher than the control (2.7%). Dimethylarsinous acid significantly increased sister chromatid exchange (SCE) and chromosomal aberrations, most of which were chromatid gaps and chromatid breaks. The cytotoxicity and the activity of dimethylarsinous acid in inducing chromosomal aberration or SCE was as effective as arsenite, but the activity was much lower than that of mitomycin C, which was used as a positive control. The most potent effects of dimethylarsinous acid on the cells were induction of aneuploids, tetraploids and c-mitosis. The toxicity of dimethylarsinous acid is strongly related to the disturbance of the normal cell cycle.(PMID: 15276414) [HMDB] [As(CH3)2(OH)] Dimethylarsinite Dimethylarsinous-acid DmaIII Me2AsOH C2H7AsO 121.998 121.971286263 dimethylarsinous acid dimethylarsinous acid 55094-22-9 C[As](C)O InChI=1S/C2H7AsO/c1-3(2)4/h4H,1-2H3 VDEGQTCMQUFPFH-UHFFFAOYSA-N belongs to the class of organic compounds known as organoarsinous acids. These are as-hydrocarbyl compounds with the general formula R2As(OH), where R is an organic group. Organoarsinous acids Organic compounds Organic acids and derivatives Organoarsinous acids Aliphatic acyclic compounds Hydrocarbon derivatives Organic metalloid salts Organic oxygen compounds Organopnictogen compounds Oxygen-containing organoarsenic compounds Trivalent organic arsenic compounds Aliphatic acyclic compound Hydrocarbon derivative Organic metalloid salt Organic oxygen compound Organic salt Organoarsenic compound Organoarsinous acid Organopnictogen compound Oxygen-containing organoarsenic compound Trivalent organic arsenic compound a small molecule methylarsinous acid Solid logp -0.14 ALOGPS logs 0.04 ALOGPS solubility 1.33e+02 g/l ALOGPS logp 0.62 ChemAxon pka_strongest_acidic 12.64 ChemAxon pka_strongest_basic -3.8 ChemAxon iupac dimethylarsinous acid ChemAxon average_mass 121.998 ChemAxon mono_mass 121.971286263 ChemAxon smiles C[As](C)O ChemAxon formula C2H7AsO ChemAxon inchi InChI=1S/C2H7AsO/c1-3(2)4/h4H,1-2H3 ChemAxon inchikey VDEGQTCMQUFPFH-UHFFFAOYSA-N ChemAxon polar_surface_area 20.23 ChemAxon refractivity 14.12 ChemAxon polarizability 8.37 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 1 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 17588 Specdb::CMs 160152 Specdb::MsMs 9080 Specdb::MsMs 9081 Specdb::MsMs 9082 Specdb::MsMs 15752 Specdb::MsMs 15753 Specdb::MsMs 15754 Specdb::MsMs 2758991 Specdb::MsMs 2758992 Specdb::MsMs 2758993 Specdb::MsMs 2949309 Specdb::MsMs 2949310 Specdb::MsMs 2949311 Specdb::MsIr 2706 Specdb::MsIr 2707 Specdb::MsIr 2708 Specdb::NmrOneD 96498 Specdb::NmrOneD 96499 Specdb::NmrOneD 96500 Specdb::NmrOneD 96501 Specdb::NmrOneD 96502 Specdb::NmrOneD 96503 Specdb::NmrOneD 96504 Specdb::NmrOneD 96505 Specdb::NmrOneD 96506 Specdb::NmrOneD 96507 Specdb::NmrOneD 96508 Specdb::NmrOneD 96509 Specdb::NmrOneD 96510 Specdb::NmrOneD 96511 Specdb::NmrOneD 96512 Specdb::NmrOneD 96513 Specdb::NmrOneD 96514 Specdb::NmrOneD 96515 Specdb::NmrOneD 96516 Specdb::NmrOneD 96517 HMDB12216 23808 #<Reference:0x000055ce320457d0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823