1.0 2011-09-21 01:50:04 UTC 2015-07-21 06:59:37 UTC FDB029097 1,2-Dehydrosalsolinol 1,2-dehydrosalsolinol(1-methyl-6,7-dihydroxy-3,4-dihydroisoquinolines) is formed through the decarboxylation of salsolinol-1-carboxylic acid (1-methyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline-1-carboxylic acid), a novel endogenous catecholic adduct of dopamine and pyruvic acid, examined in nuclei-free homogenates of rat liver, whole brain, and kidney, as well as in buffer only. Liquid chromatographic analysis of incubations for varying times (30 min to 5 h) showed that the tetrahydroisoquinoline substrate decarboxylated oxidatively, forming the DSAL (PMID: 3369867) It is involved in Tyrosine Metabolism [HMDB] 1-methyl-6,7-dihydroxy-3,4-dihydroisoquinolines 3,4-dihydro-1-methyl-6,7-Isoquinolinediol DSAL C10H11NO2 177.1998 177.078978601 1-methyl-3,4-dihydroisoquinoline-6,7-diol 1-methyl-3,4-dihydroisoquinoline-6,7-diol 4602-81-7 CC1=NCCC2=C1C=C(O)C(O)=C2 InChI=1S/C10H11NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-5,12-13H,2-3H2,1H3 DWHSGRLKLUGKOU-UHFFFAOYSA-N belongs to the class of organic compounds known as dihydroisoquinolines. These are isoquinoline derivatives where exactly two carbon atoms joined by an aromatic bond are linked with a hydrogen atom each, resulting in a CC single bond. Dihydroisoquinolines Organic compounds Organoheterocyclic compounds Dihydroisoquinolines Aromatic heteropolycyclic compounds 1-hydroxy-2-unsubstituted benzenoids Azacyclic compounds Hydrocarbon derivatives Ketimines Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds 1-hydroxy-2-unsubstituted benzenoid Aromatic heteropolycyclic compound Azacycle Benzenoid Dihydroisoquinoline Hydrocarbon derivative Imine Ketimine Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Solid logp 1.19 ALOGPS logs -2.36 ALOGPS solubility 7.81e-01 g/l ALOGPS logp 1.2 ChemAxon pka_strongest_acidic 9.31 ChemAxon pka_strongest_basic 5.96 ChemAxon iupac 1-methyl-3,4-dihydroisoquinoline-6,7-diol ChemAxon average_mass 177.1998 ChemAxon mono_mass 177.078978601 ChemAxon smiles CC1=NCCC2=C1C=C(O)C(O)=C2 ChemAxon formula C10H11NO2 ChemAxon inchi InChI=1S/C10H11NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-5,12-13H,2-3H2,1H3 ChemAxon inchikey DWHSGRLKLUGKOU-UHFFFAOYSA-N ChemAxon polar_surface_area 52.82 ChemAxon refractivity 50.69 ChemAxon polarizability 18.65 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsIr 2783 Specdb::MsIr 2784 Specdb::MsIr 2785 Specdb::CMs 39933 Specdb::CMs 69476 Specdb::CMs 161532 Specdb::MsMs 1332814 Specdb::MsMs 1332815 Specdb::MsMs 1332816 Specdb::MsMs 1447057 Specdb::MsMs 1447058 Specdb::MsMs 1447059 Specdb::MsMs 3053477 Specdb::MsMs 3053478 Specdb::MsMs 3053479 Specdb::MsMs 3116370 Specdb::MsMs 3116371 Specdb::MsMs 3116372 HMDB12490 #<Reference:0x000055ce322f3360>