1.0 2011-09-21 01:50:43 UTC 2015-07-21 06:59:38 UTC FDB029141 17-HETE Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (?)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 ?M the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive [HMDB] (5Z,8Z,11Z,14Z)-17-Hydroxyeicosa-5,8,11,14-tetraenoate (5Z,8Z,11Z,14Z)-17-Hydroxyeicosa-5,8,11,14-tetraenoic acid (all-cis)-17-Hydroxy-5,8,11,14-eicosatetraenoate (all-cis)-17-Hydroxy-5,8,11,14-eicosatetraenoic acid (all-cis)-17-Hydroxy-5,8,11,14-icosatetraenoate (all-cis)-17-Hydroxy-5,8,11,14-icosatetraenoic acid 17-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate 17-Hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid 17-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate 17-hydroxyeicosa-all-cis-5,8,11,14-tetraenoic acid 17-hydroxyeicosatetraenate C20H32O3 320.4663 320.23514489 (5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic acid 17-hete 128914-47-6 CCCC(O)C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O InChI=1S/C20H32O3/c1-2-16-19(21)17-14-12-10-8-6-4-3-5-7-9-11-13-15-18-20(22)23/h3,5-6,8-9,11-12,14,19,21H,2,4,7,10,13,15-18H2,1H3,(H,22,23)/b5-3-,8-6-,11-9-,14-12- OPPIPPRXLIDJKN-JPURVOHMSA-N belongs to the class of organic compounds known as hydroxyeicosatetraenoic acids. These are eicosanoic acids with an attached hydroxyl group and four CC double bonds. Hydroxyeicosatetraenoic acids Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic acyclic compounds Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Hydroxy fatty acids Long-chain fatty acids Monocarboxylic acids and derivatives Organic oxides Secondary alcohols Unsaturated fatty acids Alcohol Aliphatic acyclic compound Carbonyl group Carboxylic acid Carboxylic acid derivative Fatty acid Hydrocarbon derivative Hydroxy fatty acid Hydroxyeicosatetraenoic acid Long-chain fatty acid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Secondary alcohol Unsaturated fatty acid HETE Hydroxy/hydroperoxyeicosatetraenoic acids Solid logp 5.79 ALOGPS logs -5.19 ALOGPS solubility 2.07e-03 g/l ALOGPS logp 5.2 ChemAxon pka_strongest_acidic 4.82 ChemAxon pka_strongest_basic -1.3 ChemAxon iupac (5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic acid ChemAxon average_mass 320.4663 ChemAxon mono_mass 320.23514489 ChemAxon smiles CCCC(O)C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O ChemAxon formula C20H32O3 ChemAxon inchi InChI=1S/C20H32O3/c1-2-16-19(21)17-14-12-10-8-6-4-3-5-7-9-11-13-15-18-20(22)23/h3,5-6,8-9,11-12,14,19,21H,2,4,7,10,13,15-18H2,1H3,(H,22,23)/b5-3-,8-6-,11-9-,14-12- ChemAxon inchikey OPPIPPRXLIDJKN-JPURVOHMSA-N ChemAxon polar_surface_area 57.53 ChemAxon refractivity 101.62 ChemAxon polarizability 38 ChemAxon rotatable_bond_count 14 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 25472 Specdb::CMs 39970 Specdb::CMs 134269 Specdb::CMs 142003 Specdb::MsMs 322447 Specdb::MsMs 322448 Specdb::MsMs 322449 Specdb::MsMs 370354 Specdb::MsMs 370355 Specdb::MsMs 370356 Specdb::MsMs 2679382 Specdb::MsMs 2679383 Specdb::MsMs 2679384 Specdb::MsMs 3026082 Specdb::MsMs 3026083 Specdb::MsMs 3026084 HMDB12598