1.0 2011-09-21 01:51:51 UTC 2015-07-21 06:59:39 UTC FDB029207 Cyanosulfurous acid anion The OSCN- ion inhibits bacterial glyceraldehyde 3-P dehydrogenases (11, 24) and thereby stops the bacterial production of acids from sugars. The inhibition of bacterial acid production by OSCN- has been implicated as playing an important role in the prevention of dental caries lactoperoxidase in the presence of thiocyanate detoxifies hydrogen peroxide by converting it into OSCN-, and OSCN- prevents bacteria from excreting hydrogen peroxide by inhibiting glyceraldehyde 3-P dehydrogenase. Because of this inhibition, no NADH is generated in the bacteria, and the hydrogen peroxide-producing NADH oxidases become short of their substrate, NADH. This inhibition of glycolysis usually has a bacteriostatic effect. In recent studies, significant levels of OSCN- have been found in saliva collected directly from the ducts of the salivary glands . This indicates that hydrogen peroxide is actually produced within the salivary glands; thus, lactoperoxidase and thiocyanate may also play an important role in protecting the salivary glands and ducts against hydrogen peroxide toxicity. The products of the lactoperoxidase-thiocyanate-hydrogen peroxide reaction have also been reported to be bactericidal. This effect has been ascribed to OSCN-, but it has also been suggested that higher oxyacids of the thiocyanate ion, cyanosulfurous and cyanosulfuric acids, may be formed in the lactoperoxidase reaction, and these acids may be the effective molecular species in the killing [HMDB] CNSu cyanosulfurous acid CH2NO2S 92.097 91.980624003 dihydroxy-lambda3-sulfanecarbonitrile dihydroxy-lambda3-sulfanecarbonitrile O[S](O)C#N InChI=1S/CH2NO2S/c2-1-5(3)4/h3-4H QYFNKYSGTDITHU-UHFFFAOYSA-N belongs to the class of organic compounds known as thiocyanates. These are salts or esters of thiocyanic acid, with the general formula RSC#N (R=alkyl, aryl). Thiocyanates Organic compounds Organosulfur compounds Thiocyanates Aliphatic acyclic compounds Hydrocarbon derivatives Organic oxygen compounds Organonitrogen compounds Organopnictogen compounds Aliphatic acyclic compound Hydrocarbon derivative Organic nitrogen compound Organic oxygen compound Organonitrogen compound Organopnictogen compound Thiocyanate Solid logp -0.52 ALOGPS logs -0.55 ALOGPS solubility 2.62e+01 g/l ALOGPS logp -0.57 ChemAxon pka_strongest_acidic 12.21 ChemAxon pka_strongest_basic -3.9 ChemAxon iupac dihydroxy-lambda3-sulfanecarbonitrile ChemAxon average_mass 92.097 ChemAxon mono_mass 91.980624003 ChemAxon smiles O[S](O)C#N ChemAxon formula CH2NO2S ChemAxon inchi InChI=1S/CH2NO2S/c2-1-5(3)4/h3-4H ChemAxon inchikey QYFNKYSGTDITHU-UHFFFAOYSA-N ChemAxon polar_surface_area 64.25 ChemAxon refractivity 17.54 ChemAxon polarizability 7.01 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 298558 Specdb::MsMs 298559 Specdb::MsMs 298560 Specdb::MsMs 340345 Specdb::MsMs 340346 Specdb::MsMs 340347 Specdb::MsMs 2679367 Specdb::MsMs 2679368 Specdb::MsMs 2679369 Specdb::MsMs 3026070 Specdb::MsMs 3026071 Specdb::MsMs 3026072 Specdb::CMs 14737 Specdb::CMs 170812 HMDB12916