1.02011-09-21 01:52:13 UTC2015-07-21 06:59:39 UTCFDB029229IsoniazidIsoniazid (also called isonicotinyl hydrazine or INH; sold as Laniazid, Nydrazid) is an organic compound that is the first-line antituberculosis medication in prevention and treatment. First discovered in 1912 as an inhibitor of the MAO enzyme, it was first used as an antidepressant, but discontinued due to side effects. In 1951, it was later discovered that isoniazid was effective against TB. Isoniazid is never used on its own to treat active tuberculosis because resistance quickly develops.; Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically <i>M. tuberculosis</i>, <i>M. bovis</i> and <i>M. kansasii</i>. It is a highly specific agent, ineffective against other microorganisms. Isoniazid is bactericidal to rapidly-dividing mycobacteria, but is bacteriostatic if the mycobacterium is slow-growing.; Isoniazid is a prodrug and must be activated by bacterial catalase. It is activated by catalase-peroxidase enzyme KatG which couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to ketoenoylreductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of Isoniazid, including nitric oxide, that has also been shown to be important in the action of another antimycobacterial prodrug PA824. [HMDB](HBD) Human beta-defensin-1 & INH4-(Hydrazinocarbonyl)pyridine4-Pyridinecarbonylhydrazine4-Pyridinecarboxylic acid hydrazide4-Pyridinecarboxylic acid, hydrazide4-Pyridinecarboxylic hydrazide4-Pyridylcarbonyl hydrazide4-PyridylcarbonylhydrazideAbdizideAmidonAndrazideAnidrasonaAntimicinaAntituberkulosumArmacideArmazidArmazideAtcotibineAzt + isoniazidAzurenBacillenBacillinCedinCedin (aerosol)CemidonChemiazidChemidonContinazineCortinazineCotinazinCotinizinDefoninDibutinDiforinDinacrinDitubinDom-Isoniazid 300mg TabletsDow-isoniazidEbideneEralonErtubanEutizonEvalonFetefuFimaleneFRS-3FSR 3FSR-3FtivazideGINKHIAHid rasonilHidranizilHidrasonilHidrultaHidrunHycozidHydraHydrazidHydrazideHydrazide, isonicotinic acidHyozidHyzydI.a.II.a.I.I3377_FLUKAI3377_SIGMAIdo-tebinIdrazide dell'acido isonicotinico [italian]IdrazilINAHINHInh-burgthalINHd20InizidIscotinIsidrinaIsmazideIsobicinaIsocidIsocideneIsoco tinIsocotinIsohydrazideIsokinIsolynIsoneritIsonexIsoniacidIsoniazid (JP15/USP/INN)Isoniazid [ban:inn:jan]Isoniazid [inn:ban:jan]Isoniazid & CRL8131Isoniazid & eepIsoniazid & propolisIsoniazid daily for 9 monthsIsoniazid saIsoniazid(isonicotinic acid)Isoniazida [inn-spanish]IsoniazideIsoniazidum [inn-latin]IsonicazideIsonicidIsonicoIsonicotanIsonicotilIsonicotinate hydrazideIsonicotinhydrazidIsonicotinic acid hydrazideIsonicotinic hydrazideIsonicotinohydrazideisonicotinohydrazide (ACD/Name 4.0)Isonicotinoyl hydrazideIsonicotinoylhydrazideIsonicotinoylhydrazineIsonicotinsaeurehydrazid [german]Isonicotinyl hydrazideIsonicotinyl hydrazineIsonicotinylhydrazideIsonicotinylhydrazineIsonideIsonidrinIsonikazidIsonilexIsoninIsonindonIsoniritIsonitonIsonizidaIsonizideIsopyrinIsotamineIsotamine powderIsotamine Syr Pediatric 50mg/5mlIsotamine-100Isotamine-300IsotebeIsotebezidIsotinylIsozidIsozid eIsozideIsozydISZLaniazidLaniazid (TN)LaniozidLanizidMixture nameMybasannchembio884-comp3Neo-tizideNeotebenNeoxinNeumandinNevinNiadrinNiazidNicazideNicetalNicizinaNiconylNicotibinaNicotibineNicotisanNicozideNidatonNidra zidNidrazidNikozidNiplenNitadonNitebanNitebannsc 9659NydrazidNyscozidPelazidPercinPhthisenPhthivazidePms-Isoniazid 100mg/TabPms-Isoniazid 300mg/TabPms-Isoniazid Syrup 50mg/5mlPms-Isoniazid Tab 50mgPreparation 6424Prestwick_578PycazidePyreazidPyricidinPyridicinpyridine-4-carbohydrazidePyrizidinRaumanonRazideRetozideRifamateRifaterRimicidRimif onRimifonRimiphoneRimitsidRobiselinRobisellinRoxifenRu-ef-TBRY-ef-TBSanohidrazinaSauterazidSauterzidStanozideTB-phloginTB-razideTB-visTebecidTebemidTebenicTebexinTebilonTebosTeebaconinTekazinTibazideTibemidTibiazideTibisonTibivisTibusanTubazidTubazideTubecoTubecotubercidTubercidTuberianTubiconTubilysinTubizidTubomelTyvidUnicocydeUnicozydeUsaf cb-2VazadrineVederonWLN: T6NJ DVMZZidafimiaZinadonZonazideC6H7N3O137.1393137.058911861pyridine-4-carbohydrazideisoniazid54-85-3NNC(=O)C1=CC=NC=C1InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)QRXWMOHMRWLFEY-UHFFFAOYSA-N belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. Pyridinecarboxylic acids and derivatives are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.Pyridinecarboxylic acids and derivativesOrganic compoundsOrganoheterocyclic compoundsPyridines and derivativesPyridinecarboxylic acids and derivativesAromatic heteromonocyclic compoundsAzacyclic compoundsCarboxylic acid hydrazidesHeteroaromatic compoundsHydrocarbon derivativesOrganic oxidesOrganonitrogen compoundsOrganooxygen compoundsOrganopnictogen compoundsAromatic heteromonocyclic compoundAzacycleCarboxylic acid derivativeCarboxylic acid hydrazideHeteroaromatic compoundHydrocarbon derivativeOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPyridine carboxylic acid or derivativesa small moleculecarbohydrazidelogp-0.71logs-0.59solubility3.49e+01 g/llogp-0.69pka_strongest_acidic13.61pka_strongest_basic3.35iupacpyridine-4-carbohydrazideaverage_mass137.1393mono_mass137.058911861smilesNNC(=O)C1=CC=NC=C1formulaC6H7N3OinchiInChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)inchikeyQRXWMOHMRWLFEY-UHFFFAOYSA-Npolar_surface_area68.01refractivity37.46polarizability13.21rotatable_bond_count1acceptor_count3donor_count2physiological_charge0formal_charge0Specdb::EiMs761Specdb::MsIr3169Specdb::MsIr3170Specdb::MsIr3171Specdb::CMs17893Specdb::CMs161833Specdb::NmrOneD2448Specdb::NmrOneD3136Specdb::NmrOneD103078Specdb::NmrOneD103079Specdb::NmrOneD103080Specdb::NmrOneD103081Specdb::NmrOneD103082Specdb::NmrOneD103083Specdb::NmrOneD103084Specdb::NmrOneD103085Specdb::NmrOneD103086Specdb::NmrOneD103087Specdb::NmrOneD103088Specdb::NmrOneD103089Specdb::NmrOneD103090Specdb::NmrOneD103091Specdb::NmrOneD103092Specdb::NmrOneD103093Specdb::NmrOneD103094Specdb::NmrOneD103095Specdb::NmrOneD103096Specdb::NmrOneD103097Specdb::MsMs69615Specdb::MsMs69616Specdb::MsMs69617Specdb::MsMs127935Specdb::MsMs127936Specdb::MsMs127937Specdb::MsMs438007Specdb::MsMs438008Specdb::MsMs438009Specdb::MsMs438010Specdb::MsMs438011Specdb::MsMs446400Specdb::MsMs446401Specdb::MsMs446402Specdb::MsMs446403Specdb::MsMs446404Specdb::MsMs3219745Specdb::MsMs3219746Specdb::MsMs3219747Specdb::MsMs3219748Specdb::MsMs3219749Specdb::MsMs3219750HMDB129826030