1.0 2011-09-21 01:52:19 UTC 2015-07-21 06:59:40 UTC FDB029237 Leukotriene C5 Leukotriene C5 is a slow reacting substance derived from eicosapentaenoic acid.Leukotriene C5 has similar biological activity on the isolated guinea pig ileum but is less potent than is leukotriene C4. Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways. [HMDB] LTC(,5) C30H45N3O9S 623.758 623.287650743 (5S,6R,7E,9E,11Z,14Z,17Z)-6-{[(2R)-2-[(4R)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14,17-pentaenoic acid (5S,6R,7E,9E,11Z,14Z,17Z)-6-{[(2R)-2-[(4R)-4-amino-4-carboxybutanamido]-2-(carboxymethylcarbamoyl)ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14,17-pentaenoic acid 75207-09-9 CC\C=C/C\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O InChI=1S/C30H45N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h3-4,6-7,9-13,16,22-25,34H,2,5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b4-3-,7-6-,10-9-,12-11+,16-13+/t22-,23+,24+,25-/m1/s1 OSBTVMNXIHRFGN-KERZFGRDSA-N belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds. Oligopeptides Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aromatic heteromonocyclic compounds 1-hydroxy-2-unsubstituted benzenoids Alanine and derivatives Alpha amino acid amides Amino acids Amphetamines and derivatives Azacyclic compounds Carbonyl compounds Carboximidamides Carboxylic acids Guanidines Heteroaromatic compounds Histidine and derivatives Hydrocarbon derivatives Imidazolyl carboxylic acids and derivatives Isoleucine and derivatives Monoalkylamines Monocarboxylic acids and derivatives N-acyl amines N-acyl-L-alpha-amino acids N-acylpyrrolidines Organic oxides Phenylalanine and derivatives Phenylpropanoic acids Proline and derivatives Propargyl-type 1,3-dipolar organic compounds Pyrrolidinecarboxamides Secondary carboxylic acid amides Tertiary carboxylic acid amides Tyrosine and derivatives 1-hydroxy-2-unsubstituted benzenoid 3-phenylpropanoic-acid Alanine or derivatives Alpha-amino acid amide Alpha-amino acid or derivatives Alpha-oligopeptide Amine Amino acid Amino acid or derivatives Amphetamine or derivatives Aromatic heteromonocyclic compound Azacycle Azole Benzenoid Carbonyl group Carboxamide group Carboximidamide Carboxylic acid Fatty acyl Fatty amide Guanidine Heteroaromatic compound Histidine or derivatives Hydrocarbon derivative Imidazole Imidazolyl carboxylic acid derivative Isoleucine or derivatives Monocarboxylic acid or derivatives Monocyclic benzene moiety N-acyl-alpha amino acid or derivatives N-acyl-alpha-amino acid N-acyl-amine N-acyl-l-alpha-amino acid N-acylpyrrolidine N-substituted-alpha-amino acid Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Phenol Phenylalanine or derivatives Primary aliphatic amine Primary amine Proline or derivatives Propargyl-type 1,3-dipolar organic compound Pyrrolidine Pyrrolidine carboxylic acid or derivatives Pyrrolidine-2-carboxamide Secondary carboxylic acid amide Tertiary carboxylic acid amide Tyrosine or derivatives Solid logp -0.18 ALOGPS logs -5.23 ALOGPS solubility 3.65e-03 g/l ALOGPS logp -0.38 ChemAxon pka_strongest_acidic 1.8 ChemAxon pka_strongest_basic 9.31 ChemAxon iupac (5S,6R,7E,9E,11Z,14Z,17Z)-6-{[(2R)-2-[(4R)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14,17-pentaenoic acid ChemAxon average_mass 623.758 ChemAxon mono_mass 623.287650743 ChemAxon smiles CC\C=C/C\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O ChemAxon formula C30H45N3O9S ChemAxon inchi InChI=1S/C30H45N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h3-4,6-7,9-13,16,22-25,34H,2,5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b4-3-,7-6-,10-9-,12-11+,16-13+/t22-,23+,24+,25-/m1/s1 ChemAxon inchikey OSBTVMNXIHRFGN-KERZFGRDSA-N ChemAxon polar_surface_area 216.35 ChemAxon refractivity 169.63 ChemAxon polarizability 67.42 ChemAxon rotatable_bond_count 24 ChemAxon acceptor_count 10 ChemAxon donor_count 7 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 313993 Specdb::MsMs 313994 Specdb::MsMs 313995 Specdb::MsMs 359623 Specdb::MsMs 359624 Specdb::MsMs 359625 Specdb::MsMs 2325981 Specdb::MsMs 2325982 Specdb::MsMs 2325983 Specdb::MsMs 2612749 Specdb::MsMs 2612750 Specdb::MsMs 2612751 Specdb::NmrOneD 98358 Specdb::NmrOneD 98359 Specdb::NmrOneD 98360 Specdb::NmrOneD 98361 Specdb::NmrOneD 98362 Specdb::NmrOneD 98363 Specdb::NmrOneD 98364 Specdb::NmrOneD 98365 Specdb::NmrOneD 98366 Specdb::NmrOneD 98367 Specdb::NmrOneD 98368 Specdb::NmrOneD 98369 Specdb::NmrOneD 98370 Specdb::NmrOneD 98371 Specdb::NmrOneD 98372 Specdb::NmrOneD 98373 Specdb::NmrOneD 98374 Specdb::NmrOneD 98375 Specdb::NmrOneD 98376 Specdb::NmrOneD 98377 Specdb::CMs 21584 Specdb::CMs 40027 Specdb::CMs 547878 Specdb::CMs 547879 Specdb::CMs 547880 Specdb::CMs 547881 Specdb::CMs 547882 Specdb::CMs 547883 Specdb::CMs 547884 Specdb::CMs 547885 Specdb::CMs 547886 Specdb::CMs 547887 Specdb::CMs 547888 Specdb::CMs 547889 Specdb::CMs 547890 Specdb::CMs 547891 Specdb::CMs 547892 Specdb::CMs 547893 Specdb::CMs 547894 Specdb::CMs 547895 Specdb::CMs 547896 Specdb::CMs 547897 Specdb::CMs 547898 Specdb::CMs 547899 Specdb::CMs 547900 HMDB12993