1.0 2011-09-21 01:58:09 UTC 2015-07-21 06:59:46 UTC FDB029593 1,4-Dithiothreitol Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT has an epimeric compound, dithioerythritol. A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins. Cleland's reagent DL-threo-1,4-Dimercapto-2,3-butanediol DTT threo-1,4-Dimercapto-2,3-butanediol C4H10O2S2 154.251 154.012220944 (2R,3R)-1,4-disulfanylbutane-2,3-diol L-dithiothreitol 3483-12-3 O[C@@H](CS)[C@@H](O)CS InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1 VHJLVAABSRFDPM-IMJSIDKUSA-N belongs to the class of organic compounds known as 1,2-diols. These are polyols containing an alcohol group at two adjacent positions. 1,2-diols Organic compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Aliphatic acyclic compounds Alkylthiols Hydrocarbon derivatives Secondary alcohols 1,2-diol Aliphatic acyclic compound Alkylthiol Hydrocarbon derivative Organosulfur compound Secondary alcohol 1,4-dithiothreitol Solid logp 0.18 ALOGPS logs -1.48 ALOGPS solubility 5.14e+00 g/l ALOGPS logp -0.28 ChemAxon pka_strongest_acidic 9.62 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (2R,3R)-1,4-disulfanylbutane-2,3-diol ChemAxon average_mass 154.251 ChemAxon mono_mass 154.012220944 ChemAxon smiles O[C@@H](CS)[C@@H](O)CS ChemAxon formula C4H10O2S2 ChemAxon inchi InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1 ChemAxon inchikey VHJLVAABSRFDPM-IMJSIDKUSA-N ChemAxon polar_surface_area 40.46 ChemAxon refractivity 38.84 ChemAxon polarizability 15.68 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 2 ChemAxon donor_count 4 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 1540 Specdb::CMs 8250 Specdb::CMs 31573 Specdb::CMs 40128 Specdb::CMs 155369 Specdb::MsIr 2910 Specdb::MsIr 2911 Specdb::MsIr 2912 Specdb::MsMs 258639 Specdb::MsMs 258640 Specdb::MsMs 258641 Specdb::MsMs 278577 Specdb::MsMs 278578 Specdb::MsMs 278579 Specdb::MsMs 2792297 Specdb::MsMs 2792298 Specdb::MsMs 2792299 Specdb::MsMs 2917406 Specdb::MsMs 2917407 Specdb::MsMs 2917408 Specdb::NmrOneD 99698 Specdb::NmrOneD 99699 Specdb::NmrOneD 99700 Specdb::NmrOneD 99701 Specdb::NmrOneD 99702 Specdb::NmrOneD 99703 Specdb::NmrOneD 99704 Specdb::NmrOneD 99705 Specdb::NmrOneD 99706 Specdb::NmrOneD 99707 Specdb::NmrOneD 99708 Specdb::NmrOneD 99709 Specdb::NmrOneD 99710 Specdb::NmrOneD 99711 Specdb::NmrOneD 99712 Specdb::NmrOneD 99713 Specdb::NmrOneD 99714 Specdb::NmrOneD 99715 Specdb::NmrOneD 99716 Specdb::NmrOneD 99717 HMDB13593 18320 DTT Vitamin K epoxide reductase complex subunit 1 Q9BQB6 VKORC1