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Showing Compound GDP-α-D-mannose (FDB030881)

Record Information
Version1.0
Creation date2015-05-07 20:23:36 UTC
Update date2020-09-17 15:38:49 UTC
Primary IDFDB030881
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameGDP-α-D-mannose
DescriptionGuanosine diphosphate mannose, also known as gdpmannose or GDP-alpha-D-mannose, belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group. Guanosine diphosphate mannose is a strong basic compound (based on its pKa). Guanosine diphosphate mannose exists in all living species, ranging from bacteria to humans. Within humans, guanosine diphosphate mannose participates in a number of enzymatic reactions. In particular, guanosine diphosphate mannose can be biosynthesized from D-mannose 1-phosphate through its interaction with the enzyme mannose-1-phosphate guanyltransferase beta. In addition, guanosine diphosphate mannose can be converted into GDP-4-dehydro-6-deoxy-D-mannose; which is catalyzed by the enzyme GDP-mannose 4,6 dehydratase. In humans, guanosine diphosphate mannose is involved in the metabolic disorder called fructosuria. Outside of the human body, Guanosine diphosphate mannose has been detected, but not quantified in, several different foods, such as other bread, feijoa, chanterelles, cherimoya, and romaine lettuces. This could make guanosine diphosphate mannose a potential biomarker for the consumption of these foods. The alpha-anomer of GDP-D-mannose.
CAS Number3123-67-9
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
SynonymSource
GDP-D-MannoseChEBI
GDPmannoseChEBI
Guanosine 5'-(trihydrogen diphosphate), mono-alpha-D-mannopyranosyl esterChEBI
Guanosine diphosphomannoseChEBI
Guanosine pyrophosphate mannoseChEBI
GDP-alpha-D-MannoseKegg
Guanosine 5'-(trihydrogen diphosphate), mono-a-D-mannopyranosyl esterGenerator
Guanosine 5'-(trihydrogen diphosphate), mono-α-D-mannopyranosyl esterGenerator
Guanosine 5'-(trihydrogen diphosphoric acid), mono-a-D-mannopyranosyl esterGenerator
Guanosine 5'-(trihydrogen diphosphoric acid), mono-alpha-D-mannopyranosyl esterGenerator
Guanosine 5'-(trihydrogen diphosphoric acid), mono-α-D-mannopyranosyl esterGenerator
Guanosine pyrophosphoric acid mannoseGenerator
GDP-a-D-MannoseGenerator
GDP-Α-D-mannoseGenerator
Guanosine diphosphoric acid mannoseGenerator
GDP MannoseHMDB
GDP-GlucoseHMDB
GDP-MannoseHMDB
Pyrophosphate mannose, guanosineHMDB
Diphosphomannose, guanosineHMDB
Mannose, guanosine diphosphateHMDB
Diphosphate mannose, guanosineHMDB
Mannose, guanosine pyrophosphateHMDB
Mannose, GDPHMDB
Guanosine 5'-(trihydrogen diphosphate) p'-mannosyl esterHMDB
Guanosine 5'-(trihydrogen pyrophosphate) mono-D-mannosyl esterHMDB
Guanosine 5'-(trihydrogen pyrophosphate) monomannopyranosyl esterHMDB
Guanosine 5'-(trihydrogen pyrophosphate) monomannosyl esterHMDB
Guanosine 5'-diphosphate D-mannoseHMDB
Guanosine 5'-pyrophosphate D-mannosyl esterHMDB
Guanosine 5'-pyrophosphate alpha-D-mannosyl esterHMDB
Guanosine 5'-pyrophosphate α-D-mannosyl esterHMDB
Guanosine 5’-(trihydrogen diphosphate) p’-mannosyl esterHMDB
Guanosine 5’-(trihydrogen pyrophosphate) mono-D-mannosyl esterHMDB
Guanosine 5’-(trihydrogen pyrophosphate) monomannopyranosyl esterHMDB
Guanosine 5’-(trihydrogen pyrophosphate) monomannosyl esterHMDB
Guanosine 5’-diphosphate D-mannoseHMDB
Guanosine 5’-pyrophosphate D-mannosyl esterHMDB
Guanosine 5’-pyrophosphate α-D-mannosyl esterHMDB
Guanosine diphosphate mannoseHMDB
Predicted Properties
PropertyValueSource
Water Solubility7.77 g/LALOGPS
logP-1.8ALOGPS
logP-5.3ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)1.73ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count16ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area327.43 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity118.51 m³·mol⁻¹ChemAxon
Polarizability48.72 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC16H25N5O16P2
IUPAC name[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid
InChI IdentifierInChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1
InChI KeyMVMSCBBUIHUTGJ-GDJBGNAASA-N
Isomeric SMILESNC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1
Average Molecular Weight605.3411
Monoisotopic Molecular Weight605.077152801
Classification
Description Belongs to the class of organic compounds known as purine nucleotide sugars. These are purine nucleotides bound to a saccharide derivative through the terminal phosphate group.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine nucleotide sugars
Direct ParentPurine nucleotide sugars
Alternative Parents
Substituents
  • Purine nucleotide sugar
  • Purine ribonucleoside diphosphate
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • Monosaccharide phosphate
  • Organic pyrophosphate
  • Imidazopyrimidine
  • Purine
  • Hydroxypyrimidine
  • Monoalkyl phosphate
  • Monosaccharide
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Oxane
  • Phosphoric acid ester
  • Alkyl phosphate
  • Pyrimidine
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Imidazole
  • Azole
  • Secondary alcohol
  • Polyol
  • Oxacycle
  • Organoheterocyclic compound
  • Azacycle
  • Organic oxygen compound
  • Alcohol
  • Organic oxide
  • Primary alcohol
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organooxygen compound
  • Organic nitrogen compound
  • Organopnictogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Biological location:

Source:

Physico-Chemical Properties
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSGDP-α-D-mannose, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-05bu-5842490000-d73f755e03b8ad234b29Spectrum
Predicted GC-MSGDP-α-D-mannose, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-01r6-7882509000-02adbc06a0f79e803d88Spectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_7, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_8, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_9, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_1_10, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_7, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_8, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_9, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_10, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_11, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_12, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_13, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSGDP-α-D-mannose, TMS_2_14, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 32V, positivesplash10-0a4i-0000209000-fa2b35ba4f2fbdff74a32020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 32V, negativesplash10-0udi-3401309000-93213e14894fde4ba5c22020-07-21View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0001309000-586a7f020650fe518e5f2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Positivesplash10-0udi-0900000000-bba5489b865ff8d5ba782021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0006-0100900000-d5b51af9c9e0965031972021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900400000-3410bfae1c82b5e089992021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-00b9-9434300000-661dad8f3e9cd9b10a382021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0000009000-c84788b57e1d68c3a2992021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0910510000-30a5518df6f0f53ad7b72015-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0910000000-48aef418f3aa94cc35f82015-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-1900000000-438261daf883fac47d6c2015-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-1901325000-e5d0bcd5db4a59b606f82015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-1901100000-a8c00836fd0ca5a71ad12015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0pdl-3900000000-358726d071759c859d9e2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0000009000-3f663b5fce4f431e1e252021-09-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-4701986000-bb5e3a66be23d7de55e62021-09-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-05i0-3911810000-ee275d8a12bcf1e5065c2021-09-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0900002000-37d2f661727ecc1c915a2021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900001000-de8f3c7c7e6a620f0e902021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udr-2930000000-7a0fc600f843201b86c42021-09-24View Spectrum
NMRNot Available
ChemSpider IDNot Available
ChEMBL IDNot Available
KEGG Compound IDNot Available
Pubchem Compound IDNot Available
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference