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Showing Compound L-1-glycero-3-phosphocholine (FDB030952)

Record Information
Version1.0
Creation date2015-05-07 20:35:58 UTC
Update date2025-11-19 03:02:36 UTC
Primary IDFDB030952
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameL-1-glycero-3-phosphocholine
DescriptionCholine alfoscerate, also known as glycerophosphocholine or choline glycerophosphate, is a member of the class of compounds known as glycerophosphocholines. Glycerophosphocholines are lipids containing a glycerol moiety carrying a phosphocholine at the 3-position. Choline alfoscerate is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Choline alfoscerate can be found in a number of food items such as radish, strawberry guava, yellow pond-lily, and pepper (c. baccatum), which makes choline alfoscerate a potential biomarker for the consumption of these food products. L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias .
CAS Number28319-77-9
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
SynonymSource
(2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphateChEBI
Alfoscerate de cholineChEBI
Alfoscerato de colinaChEBI
alpha-GlycerophosphorylcholineChEBI
Choline alphoscerateChEBI
Choline glycerophosphateChEBI
Cholini alfoscerasChEBI
Cholini glycerophosphasChEBI
Glicerofosfato de colinaChEBI
Glycerol phosphorylcholineChEBI
Glycerol-3-phosphatidylcholineChEBI
Glycerol-3-phosphocholineChEBI
Glycerophosphate de cholineChEBI
GlycerophosphorylcholineChEBI
GPChoChEBI
L-alpha-GlycerophosphocholineChEBI
L-alpha-GlycerophosphorylcholineChEBI
L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphate inner saltChEBI
sn-3-GPCChEBI
sn-Glycero-3-phosphocholineChEBI
sn-Glycerol 3-phosphocholineChEBI
GliatilinKegg
(2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphoric acidGenerator
Alfosceric acid de cholineGenerator
a-GlycerophosphorylcholineGenerator
Α-glycerophosphorylcholineGenerator
Choline alphosceric acidGenerator
Choline glycerophosphoric acidGenerator
Glycerophosphoric acid de cholineGenerator
L-a-GlycerophosphocholineGenerator
L-Α-glycerophosphocholineGenerator
L-a-GlycerophosphorylcholineGenerator
L-Α-glycerophosphorylcholineGenerator
L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphoric acid inner saltGenerator
Choline alfosceric acidHMDB
Glycerol 3 phosphocholineHMDB
GlycerylphosphorylcholineHMDB
Alphoscerate, cholineHMDB
L alpha GlycerylphosphorylcholineHMDB
3-Phosphocholine, glycerolHMDB
Glycerol 3-phosphocholineHMDB
L-alpha-GlycerylphosphorylcholineHMDB
Alfoscerate, cholineHMDB
Glycerophosphate, cholineHMDB
2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium inner saltHMDB
a-GlycerylphosphorylcholineHMDB
alpha-GlycerylphosphorylcholineHMDB
Choline alfoscerateHMDB
GlycerophosphatidylcholineHMDB
GPCHMDB
Hydrogen glycerophosphate cholineHMDB
CeretonHMDB
CholicerinHMDB
CholitilineHMDB
DelecitHMDB
Glycerol 3-phosphorylcholineHMDB
Glycerophosphoric acid choline esterHMDB
Glyceryl 3-phosphorylcholineHMDB
GlycerylphosphocholineHMDB
L-alpha-GPCHMDB
L-Α-GPCHMDB
L-Α-glycerylphosphorylcholineHMDB
O-(sn-Glycero-3-phosphoryl)-cholineHMDB
sn-Glycero-3-phosphorylcholineHMDB
Α-glycerylphosphorylcholineHMDB
GlycerophosphocholineChEBI
Predicted Properties
PropertyValueSource
Water Solubility8.96 g/LALOGPS
logP-2.6ALOGPS
logP-5.7ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area99.05 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity68.68 m³·mol⁻¹ChemAxon
Polarizability24.77 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC8H20NO6P
IUPAC name(2-{[(2R)-2,3-dihydroxypropyl phosphono]oxy}ethyl)trimethylazanium
InChI IdentifierInChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1
InChI KeySUHOQUVVVLNYQR-MRVPVSSYSA-N
Isomeric SMILES[H][C@@](O)(CO)COP([O-])(=O)OCC[N+](C)(C)C
Average Molecular Weight257.223
Monoisotopic Molecular Weight257.102824366
Classification
Description Belongs to the class of organic compounds known as glycerophosphocholines. These are lipids containing a glycerol moiety carrying a phosphocholine at the 3-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct ParentGlycerophosphocholines
Alternative Parents
Substituents
  • Glycero-3-phosphocholine
  • Phosphocholine
  • Dialkyl phosphate
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Tetraalkylammonium salt
  • Quaternary ammonium salt
  • 1,2-diol
  • Secondary alcohol
  • Organic nitrogen compound
  • Organic salt
  • Hydrocarbon derivative
  • Primary alcohol
  • Organic oxide
  • Organopnictogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Organoleptic effect:

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Process

Naturally occurring process:

Role

Industrial application:

Biological role:

Physico-Chemical Properties
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSL-1-glycero-3-phosphocholine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-001j-7910000000-79a0f6ec434740d09410Spectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TMS_2_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSL-1-glycero-3-phosphocholine, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-004i-9310000000-e2633e56c869520547102021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-1690000000-53ffc11b39ba8f89f8032021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-d4d2c5d7e0856e9486242021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-004i-9400000000-848201d8ac3bd454c67a2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Positivesplash10-01w1-9300000000-987e5431e2d611fa50322021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-2490000000-efb55f1ddbed9f1a87542021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Positivesplash10-0udi-1900000000-df7b0a6ce3c788063f532021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0zfr-0960000000-7df186ffc569be161b392021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-052r-9140000000-3347b58fbc5fe0b0a2012019-02-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a7r-9210000000-60118aed826a14bb4cb12019-02-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4r-9000000000-b6ac875e42841f04bcfc2019-02-22View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-0390000000-9adc870a20cd016e3aa22019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0kor-2920000000-b31eb4ca99ba45d9f9312019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9100000000-dec05a487d7ae73f1d272019-02-23View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-0090000000-bd45c4f9a61bbdbbd2d62021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a4i-3960000000-2d618fc6f1a9c434909c2021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-a5e502a2627af2048a1f2021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0960000000-782cafcc84f2e1b585612021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-0900000000-5fbae562ef71fe1bd5522021-09-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0079-9800000000-00d2deed17b9ac0f57892021-09-24View Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Spectrum
ChemSpider ID571409
ChEMBL IDCHEMBL1567463
KEGG Compound IDNot Available
Pubchem Compound ID657272
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDAlpha-GPC
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference