Record Information
Version1.0
Creation date2020-04-20 20:17:03 UTC
Update date2020-04-21 18:03:45 UTC
Primary IDFDB112383
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameFolinic acid
DescriptionFolinic acid, also known as (6S)-leucovorin or levoleucovorin, belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit. Folinic acid has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make folinic acid a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on Folinic acid.
CAS NumberNot Available
Structure
Thumb
Synonyms
SynonymSource
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acidChEBI
(6S)-Folinic acidChEBI
(6S)-LeucovorinChEBI
(S)-LeucovorinChEBI
Citrovorum factorChEBI
L-Folinic acidChEBI
LevofoleneChEBI
Levofolinic acidChEBI
LevoleucovorinChEBI
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acidChEBI
(6S)-5-Formyl-5,6,7,8-tetrahydrofolateGenerator
(6S)-FolinateGenerator
L-FolinateGenerator
LevofolinateGenerator
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamateGenerator
FolinateGenerator
5-FormyltetrahydrofolateHMDB
Pteroyl-D-glutamateHMDB
5 FormyltetrahydropteroylglutamateHMDB
5-FormyltetrahydropteroylglutamateHMDB
Calcium folinateHMDB
Folinic acid-SFHMDB
LeucovorinHMDB
Leucovorin, (S)-isomerHMDB
Leucovorin, monosodium saltHMDB
Leucovorin, (R)-isomerHMDB
Leucovorin, calciumHMDB
Leucovorin, calcium (1:1) salt, (DL)-isomerHMDB
Leucovorin, calcium (1:1) salt, (S)-isomerHMDB
LeukovorinHMDB
LeukovorumHMDB
Monosodium salt leucovorinHMDB
WellcovorinHMDB
Levo leucovorinHMDB
6 S LeucovorinHMDB
Acid, folinicHMDB
Factor, citrovorumHMDB
Folinic acid SFHMDB
FusilevHMDB
Leucovorin, calcium (1:1) salt, pentahydrateHMDB
Leucovorin, monopotassium salt, (S)-isomerHMDB
N(5)-FormyltetrahydrofolateHMDB
S-LeucovorinHMDB
5 FormyltetrahydrofolateHMDB
6-S-LeucovorinHMDB
6S LeucovorinHMDB
6S-LeucovorinHMDB
Calcium leucovorinHMDB
Folinate, calciumHMDB
Leucovorin, (D)-isomerHMDB
Leucovorin, (DL)-isomerHMDB
Leucovorin, calcium (1:1) saltHMDB
Leucovorin, monosodium salt, (S)-isomerHMDB
S LeucovorinHMDB
Levo-leucovorinHMDB
5-Formyl-(6S)-tetrahydrofolic acidHMDB
5-Formyl-5,6,7,8-tetrahydrofolic acidHMDB
5-Formyltetrahydrofolic acidHMDB
5-Formyltetrahydropteroylglutamic acidHMDB
CFHMDB
KunyrinHMDB
LeucoverinHMDB
N5-Formyl-5,6,7,8-tetrahydrofolic acidHMDB
N5-Formyl-THFHMDB
N5-Formyltetrahydrofolic acidHMDB
WelcovorinHMDB
(6S)-5-FormyltetrahydrofolateHMDB
(6S)-5-Formyltetrahydrofolic acidHMDB
Folinic acidMeSH
Predicted PropertiesNot Available
Chemical FormulaC20H23N7O7
IUPAC name
InChI IdentifierInChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1
InChI KeyVVIAGPKUTFNRDU-STQMWFEESA-N
Isomeric SMILESNC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2C=O)N1
Average Molecular Weight473.4393
Monoisotopic Molecular Weight473.165896125
Classification
Description Belongs to the class of organic compounds known as tetrahydrofolic acids. These are heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with at least one L-glutamic acid unit.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPteridines and derivatives
Sub ClassPterins and derivatives
Direct ParentTetrahydrofolic acids
Alternative Parents
Substituents
  • Tetrahydrofolic acid
  • Glutamic acid or derivatives
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Hippuric acid
  • Hippuric acid or derivatives
  • Alpha-amino acid or derivatives
  • Aminobenzamide
  • Aminobenzoic acid or derivatives
  • Benzamide
  • Benzoic acid or derivatives
  • Benzoyl
  • Aniline or substituted anilines
  • Phenylalkylamine
  • Aminopyrimidine
  • Secondary aliphatic/aromatic amine
  • Pyrimidone
  • Dicarboxylic acid or derivatives
  • Benzenoid
  • Pyrimidine
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Vinylogous amide
  • Tertiary carboxylic acid amide
  • Secondary carboxylic acid amide
  • Amino acid or derivatives
  • Amino acid
  • Carboxamide group
  • Secondary amine
  • Carboxylic acid
  • Carboxylic acid derivative
  • Azacycle
  • Organooxygen compound
  • Carbonyl group
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Amine
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Primary amine
  • Organonitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
OntologyNo ontology term
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MSNot Available
MS/MSNot Available
NMRNot Available
ChemSpider IDNot Available
ChEMBL IDNot Available
KEGG Compound IDNot Available
Pubchem Compound IDNot Available
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference