| Synonyms | | Synonym | Source |
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| Eicosapentaenoate | Generator | | (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoate | Generator | | (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid | biospider | | (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate | biospider | | (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid | biospider | | (5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenoic acid | biospider | | (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoate | Generator | | (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid | biospider | | (all-cis)-5,8,11,14,17-Eicosapentaenoic acid | biospider | | (all-Z)-5,8,11,14,17-Eicosapentaenoate | Generator | | (all-Z)-5,8,11,14,17-Eicosapentaenoic acid | biospider | | (all-Z)-Delta5,8,11,14,17-Eicosapentaenoic acid | biospider | | (Z,Z,Z,Z,Z)-5,8,11,14,17-Eicosapentaenoic acid | biospider | | 5,8,11,14,17-EICOSAPENTAENOate | Generator | | 5,8,11,14,17-EICOSAPENTAENOIC ACID | ChEBI | | 5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)- | biospider | | 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)- (8CI) | biospider | | 5,8,11,14,17-Icosapentaenoate | Generator | | 5,8,11,14,17-Icosapentaenoic acid | ChEBI | | 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoate | biospider | | 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid | biospider | | all-cis-5,8,11,14,17-Eicosapentaenoate | Generator | | all-cis-5,8,11,14,17-Eicosapentaenoic acid | ChEBI | | all-cis-Icosa-5,8,11,14,17-pentaenoate | Generator | | all-cis-Icosa-5,8,11,14,17-pentaenoic acid | biospider | | all-cis-Icosapentaenoate | biospider | | all-cis-Icosapentaenoic acid | biospider | | C20:5 omega-3 | biospider | | cis-5,8,11,14,17-Eicosapentaenoate | biospider | | cis-5,8,11,14,17-Eicosapentaenoic acid | biospider | | cis-5,8,11,14,17-EPA | ChEBI | | cis-delta(5,8,11,14,17)-Eicosapentaenoate | Generator | | cis-Delta(5,8,11,14,17)-Eicosapentaenoic acid | biospider | | cis-δ(5,8,11,14,17)-eicosapentaenoate | Generator | | cis-δ(5,8,11,14,17)-eicosapentaenoic acid | Generator | | cis, cis, cis, cis, cis-Eicosa-5,8,11,14,17-pentaenoate | Generator | | cis, cis, cis, cis, cis-Eicosa-5,8,11,14,17-pentaenoic acid | ChEBI | | EPA | biospider | | Icosapent | ChEBI | | Icosapent, INN | db_source | | Icosapentaenoate | biospider | | Icosapentaenoic acid | biospider | | Icosapento | ChEBI | | Icosapentum | ChEBI | | Timnodonate | biospider | | Timnodonic acid | db_source |
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| Health Effects / Bioactivities | | Descriptor | ID | Definition | Reference |
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| 5-hydroxyeicosatetraenoic-acid inhibitor | 35222 | An agent that blocks the activity of 5-lipoxygenase, reducing leukotriene production and inflammation. Therapeutically, it's used to treat asthma, allergic rhinitis, and other inflammatory conditions, providing relief from symptoms such as congestion and bronchospasm. | DUKE | | Anti-arthritic | 52217 | An agent that reduces joint inflammation and alleviates symptoms of arthritis, commonly used in managing rheumatoid arthritis, osteoarthritis, and other inflammatory joint disorders, to improve mobility and quality of life. | DUKE | | Anti-atherotic | 38070 | An agent that prevents or slows the formation of atheromas (plaques) in arteries, reducing the risk of cardiovascular disease. It inhibits the accumulation of lipids and inflammatory cells, promoting healthy blood vessel function. Therapeutically, anti-atherotics are used to manage atherosclerosis, hyperlipidemia, and prevent cardiovascular events such as heart attacks and strokes. | DUKE | | Anti dermatitic | 50177 | An agent that reduces skin inflammation and irritation, commonly used to treat dermatitis, eczema, and other skin disorders, providing relief from itching, redness, and swelling. | DUKE | | Anti fibrosarcomic | | An agent that inhibits the growth of fibrosarcoma, a type of cancer characterized by malignant fibroblasts. It plays a biological role in regulating cell proliferation, and has therapeutic applications in oncology. Key medical uses include treating fibrosarcoma and other soft tissue sarcomas, reducing tumor growth and improving patient outcomes. | DUKE | | Anti-inflammatory | 35472 | An agent that reduces inflammation, playing a biological role in suppressing immune responses and therapeutic applications in managing pain, swelling, and redness. Key medical uses include treating arthritis, allergies, and autoimmune disorders, as well as relieving symptoms of conditions such as asthma and dermatitis. | DUKE | | Anti-ischemic | 52217 | An agent that reduces or prevents tissue damage from inadequate blood flow, commonly used to manage angina, heart attacks, and strokes by improving oxygen delivery and reducing cardiac workload. | DUKE | | Anti leukemic | 35610 | An agent that targets and inhibits the growth of leukemia cells, playing a crucial role in cancer treatment. Therapeutically, it is used to induce remission, manage symptoms, and improve survival rates in patients with leukemia. Key medical uses include treating acute and chronic leukemia, lymphoma, and other hematological malignancies. | DUKE | | Anti leukotriene-B4 | 35222 | An agent that inhibits leukotriene B4, reducing inflammation and immune responses. It has therapeutic applications in managing inflammatory diseases, such as asthma and arthritis, by blocking leukotriene B4's role in attracting white blood cells to sites of inflammation. Key medical uses include treating respiratory and autoimmune disorders. | DUKE | | Anti-melanomic | 35610 | An agent that inhibits melanin production, reducing melanoma cell growth. It has therapeutic applications in treating skin cancers, particularly melanoma, and key medical uses include preventing tumor progression and metastasis, as well as managing pigmentation disorders. | DUKE | | Anti metastatic | 35610 | An agent that inhibits cancer cell spread, reducing tumor metastasis. It plays a biological role in blocking cell migration and invasion, and has therapeutic applications in cancer treatment. Key medical uses include preventing cancer recurrence and improving survival rates in patients with various types of cancer. | DUKE | | Anti proliferant | | An agent that prevents or inhibits cell growth and division, used therapeutically to treat cancer, manage tumor growth, and prevent restenosis after angioplasty, reducing abnormal cell proliferation. | DUKE | | Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE | | Collagenase inhibitor | 23924 | An agent that blocks the activity of collagenase, an enzyme that breaks down collagen. It reduces tissue damage and inflammation, commonly used in managing conditions such as osteoarthritis, tendonitis, and wound healing. | DUKE | | Cyclooxygenase-2 inhibitor | 50629 | An agent that blocks the activity of cyclooxygenase-2 (COX-2), reducing inflammation and pain. Therapeutically, it is used to manage conditions such as arthritis, menstrual cramps, and other inflammatory disorders, providing relief from symptoms with reduced gastrointestinal side effects compared to non-selective NSAIDs. | DUKE | | Differentiator | | An agent that induces cell differentiation, promoting mature cell formation. Its biological role involves regulating cell growth and development. Therapeutically, it has applications in cancer treatment, helping to mature cancer cells, making them more susceptible to chemotherapy. Key medical uses include leukemia and other malignancies, where differentiation therapy can improve treatment outcomes. | DUKE | | Hypotensive | | An agent that lowers blood pressure, playing a biological role in regulating cardiovascular function. Therapeutically, it's used to manage hypertension, heart failure, and angina, with key medical applications in preventing stroke, kidney disease, and cardiac complications. | DUKE | | Nephroprotective | 76595 | An agent that protects the kidneys from damage, reducing inflammation and oxidative stress. Therapeutically, it helps prevent or treat kidney diseases, such as nephropathy and acute kidney injury, and is used in managing conditions like diabetes and hypertension to preserve renal function. | DUKE | | Tyrosine-kinase inhibitor | 23924 | An agent that blocks tyrosine kinase enzymes, reducing cell signaling and proliferation. Therapeutically, it's used to treat cancers, such as leukemia and breast cancer, by inhibiting tumor growth, and also has applications in managing certain autoimmune and inflammatory diseases. | DUKE | | VEGF inhibitor | 35222 | An agent that blocks the activity of Vascular Endothelial Growth Factor (VEGF), reducing angiogenesis. Therapeutically, it's used to treat cancer, age-related macular degeneration, and diabetic retinopathy by inhibiting tumor growth and abnormal blood vessel formation. | DUKE |
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