1.0 2010-04-08 22:09:57 UTC 2018-05-28 23:33:18 UTC FDB012017 Polyvidone It is used as a diluent in colour additive mixtures for marking food; in coatings on fresh citrus fruits; as a clarifying agent for beer, wine and vinegar; as a tableting adjuvant A cross-linked form of PVP is also used as a disintegrant (see also excipients) in pharmaceutical tablets. It is also known as cross-linked polyvinyl pyrrolidone, Polyvinyl Polypyrrolidone (PVPP), crospovidone, crospolividone. Basically, PVPP is a highly cross-linked version of PVP, which makes it insoluble in water but it still absorbs water and swells very rapidly and generate a swelling force. That is why it can be used a disintegrant in tablets. It is also used to bind impurities to remove them from solutions.It is also used as a fining to extract impurities (via agglomeration followed by filtration). Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced. PVPP can be used as well as a drug taken as a tablet or suspension and it absorbs compounds (so called Endotoxins) causing diarrhoea. (Cf. bone char, charcoal.); As a food additive, PVP is a stabilizer and has E number E1201. PVPP is E1202. It is also used in the wine industry as a fining agent for white wine. Other references state that as polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin. Therefore, its use in the production should not be a problem for vegans.; PVP is soluble in water and other polar solvents. In water it has the useful property of Newtonian viscosity. When dry it is a light flaky powder, which readily absorbs up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.; PVP was first synthesized by Prof. Walter Reppe and a patent was filed in 1939 for one of the most interesting derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.; Polyvinylpolypyrrolidone (PVPP, crospovidone) is a highly cross-linked modification of PVP.; Polyvinylpyrrolidone (PVP) is a water-soluble polymer made from the monomer N-vinylpyrrolidone:. 'Kollidon 25' 'plasdone' 1-Ethenyl-2-pyrrolidinone 1-Ethenyl-2-pyrrolidinone (9CI) 1-Ethenyl-2-pyrrolidinone homopolymer 1-Ethenyl-2-pyrrolidinone homopolymer, 9CI 1-Ethenyl-2-pyrrolidinone polymers 1-Ethenyl-2-pyrrolidinone, homopolymer 1-Vinyl-2-pyrrolidinone 1-Vinyl-2-pyrrolidinone cross-linked insoluble polymer 1-Vinyl-2-pyrrolidinone homopolymer 1-Vinyl-2-pyrrolidinone polymer 1-Vinyl-2-pyrrolidinone, monomer 1-Vinyl-2-pyrrolidinone, polymer 1-Vinyl-2-pyrrolidone 1-Vinyl-2-pyrrolidone polymer 1-vinylpyrrolidin-2-one 1-Vinylpyrrolidinone 1-Vinylpyrrolidone 2-Pyrrolidinone, 1-ethenyl- 2-Pyrrolidinone, 1-ethenyl-, homopolymer 2-Pyrrolidinone, 1-ethenyl, homopolymer 2-Pyrrolidinone, 1-vinyl- 2-Pyrrolidinone, 1-vinyl-, polymers Agent AT 717 Agent AT-717 Agrimer Albigen a Aldacol q Antaron P 804 Bolinan Crospovidone Disadine Ganex P 804 Ganex P-804 Hemodesis Hemodez K 115 (polyamide) K 25 K 25 (polymer) K 25 (VAN) K 30 K 30 (polymer) K 30 (VAN) K 60 K 60 (polymer) K 60 (VAN) K115 (polyamide) K25 (polymer) K30 (polymer) K60 (polymer) Kollidin CLM Kollidon Kollidon 17 Kollidon 25 Kollidon 30 Kollidon CL Luviskol Luviskol K 30 Luviskol K 90 Luviskol K-30 Luviskol K30 Luviskol K90 N-vinyl pyrrolidone N-Vinyl-2-pyrrolidinone N-Vinyl-2-pyrrolidone N-Vinyl-2-pyrrolidone polymer N-vinylbutyrolactam polymer N-vinylpyrrolidinone N-vinylpyrrolidinone polymer N-vinylpyrrolidone N-vinylpyrrolidone polymer N-Vinylpyrrolidone-2 Neocompensan Peragal ST Peregal ST Periston Periston-n Peviston Plasdone Plasdone 4 Plasdone K 29-32 Plasdone K-26/28 Plasdone No. 4 Plasdone XL Plasmosan Polividone Polividone [dcit] Poly-n-vinyl pyrrolidone Poly-n-vinylpyrrolidone Poly(1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl) Poly(1-(2-oxo-1-pyrrolidinyl)ethylene) Poly(1-ethenyl-2-pyrrolidinone) Poly(1-vinyl-2-pyrrolidinone) Poly(1-vinyl-2-pyrrolidinone) homopolymer Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.1 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.2 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.3 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.4 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.5 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.6 Poly(1-vinyl-2-pyrrolidinone) hueper's polymer no.7 Poly(1-vinyl-2-pyrrolidone) Poly(1-vinylpyrrolidinone) Poly(N-vinyl-2-pyrrolidinone) Poly(N-vinyl-2-pyrrolidone) Poly(n-vinylbutyrolactam) Poly(n-vinylpyrrolidinone) Poly(n-vinylpyrrolidone) Poly(vinylpolypyrrolidone) Poly(vinylpyrrolidinone) Poly(vinylpyrrolidone) Polyclar a. t Polyclar a. t. Polyclar at Polyclar h Polyclar l Polyclar-at Polygyl Polyplasdone Polyplasdone XL Polyvidonum Polyvinyl pyrrolidone Polyvinylpolypyrrolidone Polyvinylpyrrolidone Polyvinylpyrrolidone polymers Polyvinylpyrrolidone, cross-linked Povidone Povidone (usp xix) Povidone [usan:inn:ban] Povidone, BAN, USAN Povidone(usan) Protagent PVP 1 PVP 2 PVP 3 PVP 4 PVP 5 PVP 6 PVP 7 PVP K 3 PVP-K 15 PVP-K 3 PVP-K 30 PVP-K 60 PVP-K 90 PVP10_SIAL PVP40_SIAL PVPP Refresh Sauflon Soothe Subtosan Tears plus Tolpovidone I 131 Tolpovidone I 131 [USAN:INN] Tolpovidone I-131 Toxobin V-pyrol Vinisil Vinyl-2-pyrrolidone Vinylbutyrolactam Vinylpyrrolidinone Vinylpyrrolidinone polymer Vinylpyrrolidone Vinylpyrrolidone polymer C6H13NOP2 177.121 177.047237067 1-(1,2-diphosphanylethyl)pyrrolidin-2-one 1-(1,2-diphosphanylethyl)pyrrolidin-2-one 9003-39-8 PCC(P)N1CCCC1=O InChI=1S/C6H13NOP2/c8-5-2-1-3-7(5)6(10)4-9/h6H,1-4,9-10H2 LQIAZOCLNBBZQK-UHFFFAOYSA-N belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. N-alkylpyrrolidines Organic compounds Organoheterocyclic compounds Pyrrolidines N-alkylpyrrolidines Aliphatic heteromonocyclic compounds Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Lactams Organic oxides Organonitrogen compounds Organophosphorus compounds Organopnictogen compounds Pyrrolidine-2-ones Tertiary carboxylic acid amides 2-pyrrolidone Aliphatic heteromonocyclic compound Azacycle Carbonyl group Carboxamide group Carboxylic acid derivative Hydrocarbon derivative Lactam N-alkylpyrrolidine Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organophosphorus compound Organopnictogen compound Pyrrolidone Tertiary carboxylic acid amide logp -0.77 ALOGPS logs 0.00 ALOGPS solubility 1.79e+02 g/l ALOGPS melting_point 110 - 180 °C (glass temperature) logp -1.4 ChemAxon pka_strongest_basic -1.1 ChemAxon iupac 1-(1,2-diphosphanylethyl)pyrrolidin-2-one ChemAxon average_mass 177.121 ChemAxon mono_mass 177.047237067 ChemAxon smiles PCC(P)N1CCCC1=O ChemAxon formula C6H13NOP2 ChemAxon inchi InChI=1S/C6H13NOP2/c8-5-2-1-3-7(5)6(10)4-9/h6H,1-4,9-10H2 ChemAxon inchikey LQIAZOCLNBBZQK-UHFFFAOYSA-N ChemAxon polar_surface_area 20.31 ChemAxon refractivity 43.21 ChemAxon polarizability 16.67 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 25310 Specdb::CMs 133203 Specdb::CMs 140937 Specdb::MsIr 6300 Specdb::MsIr 6301 Specdb::MsMs 322033 Specdb::MsMs 322034 Specdb::MsMs 322035 Specdb::MsMs 369820 Specdb::MsMs 369821 Specdb::MsMs 369822 Specdb::MsMs 2468617 Specdb::MsMs 2468618 Specdb::MsMs 2468619 Specdb::MsMs 2493062 Specdb::MsMs 2493063 Specdb::MsMs 2493064 Specdb::NmrOneD 123238 Specdb::NmrOneD 123239 Specdb::NmrOneD 123240 Specdb::NmrOneD 123241 Specdb::NmrOneD 123242 Specdb::NmrOneD 123243 Specdb::NmrOneD 123244 Specdb::NmrOneD 123245 Specdb::NmrOneD 123246 Specdb::NmrOneD 123247 Specdb::NmrOneD 123248 Specdb::NmrOneD 123249 Specdb::NmrOneD 123250 Specdb::NmrOneD 123251 Specdb::NmrOneD 123252 Specdb::NmrOneD 123253 Specdb::NmrOneD 123254 Specdb::NmrOneD 123255 Specdb::NmrOneD 123256 Specdb::NmrOneD 123257 HMDB33843 #<Reference:0x000055ce315d1380> #<Reference:0x000055ce315d1178> #<Reference:0x000055ce315d0f20>