1.0 2010-04-08 22:10:11 UTC 2019-11-26 03:06:52 UTC FDB012468 Pyrazine Maillard product In the Staedel-Rugheimer pyrazine synthesis (1876) 2-chloroacetophenone is reacted with ammonia to the amino ketone, then condensed and then oxidized to a pyrazine A variation is the Gutknecht Pyrazine Synthesis (1879) also based on this selfcondensation but differing in the way the alpha-ketoamine is synthesised (the chlorine compound in the above method is a lachrymatory agent); Pyrazine is a heterocyclic aromatic organic compound.; Pyrazine is a symmetrical molecule with point group D2h. It is found in folic acid in the form of pterin. Derivatives like Phenazine are well known for their antitumor, antibiotic and diuretic activity. Pyrazine is less basic in nature than pyridine, pyridazine and pyrimidine. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human polymorphonuclear leukocytes. Tetramethylpyrazine is also a component of some herbs in Traditional Chinese Medicine. 1, 4-Diazabenzene 1,4-Diazabenzene 1,4-Diazin 1,4-Diazine 2-Cyanopyrazine Cyanopyrazine P-diazine Paradiazine Piazine Piazine (obsol.) Pyrazin PYZ C4H4N2 80.088 80.037448138 pyrazine pyrazine 290-37-9 C1=CN=CC=N1 InChI=1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H KYQCOXFCLRTKLS-UHFFFAOYSA-N belongs to the class of organic compounds known as pyrazines. Pyrazines are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms. Pyrazines Organic compounds Organoheterocyclic compounds Diazines Pyrazines Aromatic heteromonocyclic compounds Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Organonitrogen compounds Organopnictogen compounds Aromatic heteromonocyclic compound Azacycle Heteroaromatic compound Hydrocarbon derivative Organic nitrogen compound Organonitrogen compound Organopnictogen compound Pyrazine diazine pyrazines logp -0.29 ALOGPS logs 0.82 ALOGPS solubility 5.34e+02 g/l ALOGPS melting_point Mp 54-56° (47°) logp -0.46 ChemAxon pka_strongest_basic 0.88 ChemAxon iupac pyrazine ChemAxon average_mass 80.088 ChemAxon mono_mass 80.037448138 ChemAxon smiles C1=CN=CC=N1 ChemAxon formula C4H4N2 ChemAxon inchi InChI=1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H ChemAxon inchikey KYQCOXFCLRTKLS-UHFFFAOYSA-N ChemAxon polar_surface_area 25.78 ChemAxon refractivity 21.74 ChemAxon polarizability 7.62 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 2 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 21313 Specdb::CMs 27090 Specdb::CMs 29392 Specdb::CMs 101557 Specdb::CMs 101558 Specdb::CMs 131494 Specdb::CMs 139228 Specdb::MsIr 6463 Specdb::MsIr 6464 Specdb::NmrOneD 124718 Specdb::NmrOneD 124719 Specdb::NmrOneD 124720 Specdb::NmrOneD 124721 Specdb::NmrOneD 124722 Specdb::NmrOneD 124723 Specdb::NmrOneD 124724 Specdb::NmrOneD 124725 Specdb::NmrOneD 124726 Specdb::NmrOneD 124727 Specdb::NmrOneD 124728 Specdb::NmrOneD 124729 Specdb::NmrOneD 124730 Specdb::NmrOneD 124731 Specdb::NmrOneD 124732 Specdb::NmrOneD 124733 Specdb::NmrOneD 124734 Specdb::NmrOneD 124735 Specdb::NmrOneD 124736 Specdb::NmrOneD 124737 Specdb::MsMs 74073 Specdb::MsMs 74074 Specdb::MsMs 74075 Specdb::MsMs 133368 Specdb::MsMs 133369 Specdb::MsMs 133370 Specdb::MsMs 448303 Specdb::MsMs 448304 Specdb::MsMs 448305 Specdb::MsMs 448306 Specdb::MsMs 448307 Specdb::MsMs 448308 Specdb::MsMs 448309 Specdb::MsMs 448310 Specdb::MsMs 448311 Specdb::MsMs 448312 Specdb::MsMs 448549 Specdb::MsMs 448550 Specdb::MsMs 448551 Specdb::MsMs 448552 Specdb::MsMs 448553 Specdb::MsMs 448554 Specdb::MsMs 448555 Specdb::MsMs 448556 Specdb::MsMs 448557 HMDB34176 30953 #<Reference:0x000055ce31728b98> Asparagus Type 1 specific Asparagus officinalis 4686 Corn Type 1 specific Zea mays 4577 0.0 0.0 0.0 mg/L Fenugreek Type 1 specific Trigonella foenum-graecum 78534 Kohlrabi Type 1 specific Brassica oleracea var. gongylodes 109379 Taco Type 2 specific 0.0 0.0 0.0 mg/100 g Tortilla chip Type 2 specific barley hazelnut pungent roasted sweet corn