Record Information
Version1.0
Creation date2011-09-21 00:12:44 UTC
Update date2019-11-26 03:21:02 UTC
Primary IDFDB022360
Secondary Accession Numbers
  • FDB030585
Chemical Information
FooDB NamePhosphoribosylformylglycineamidine
DescriptionPhosphoribosylformylglycineamidine, also known as FGAM, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. Phosphoribosylformylglycineamidine is a very strong basic compound (based on its pKa). Phosphoribosylformylglycineamidine exists in all living organisms, ranging from bacteria to humans. Phosphoribosylformylglycineamidine has been detected, but not quantified in, several different foods, such as sourdocks, cassava, cardamoms, wheats, and rosemaries. This could make phosphoribosylformylglycineamidine a potential biomarker for the consumption of these foods.
CAS Number37721-04-3
Structure
Thumb
Synonyms
SynonymSource
1-(5'-Phosphoribosyl)-N-formylglycinamidineKegg
5'-Phosphoribosyl-N-formylglycinamidineKegg
5'-PhosphoribosylformylglycinamidineKegg
2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidineKegg
5'-Phosphoribosyl-N-formyl glycineamidineHMDB
FGAMHMDB
N-(2-Amino-2-iminoethyl)-N-(5-O-phosphono-b-D-ribofuranosyl)-formamideHMDB
N-(2-Amino-2-iminoethyl)-N-(5-O-phosphono-beta-delta-ribofuranosyl)-formamideHMDB
1-(5’-Phosphoribosyl)-N-formylglycinamidineHMDB
2-(Formamido)-N1-(5'-phosphoribosyl)acetamidineHMDB
2-(Formamido)-N1-(5’-phosphoribosyl)acetamidineHMDB
2-Formamido-N(1)-(5-O-phosphonato-D-ribosyl)acetamidineHMDB
5'-Phosphoribosyl-alpha-N-formylglycineamidineHMDB
5'-Phosphoribosyl-α-N-formylglycineamidineHMDB
5’-Phosphoribosyl-N-formyl glycineamidineHMDB
5’-Phosphoribosyl-N-formylglycinamidineHMDB
5’-Phosphoribosyl-α-N-formylglycineamidineHMDB
5’-PhosphoribosylformylglycinamidineHMDB
N-[2-Imino-2-[(5-O-phosphono-beta-D-ribofuranosyl)amino]ethyl]formamideHMDB
N-[2-Imino-2-[(5-O-phosphono-β-D-ribofuranosyl)amino]ethyl]formamideHMDB
PhosphoribosylformylglycineamidineHMDB
Formylglycinamidine ribonucleotideHMDB
PhosphoribosylformylglycinamidineHMDB
1-(5'-Oribosyl)-N-formylglycinamidineKegg
2-(Formamido)-N1-(5-O-D-ribosyl)acetamidineKegg
5-Oribosyl-N-formylglycineamidineHMDB
5-phosphoribosyl-N-formylglycineamidinehmdb
5'-Oribosyl-N-formyl glycineamidineHMDB
5'-Oribosyl-N-formylglycinamidineKegg
5'-OribosylformylglycinamidineKegg
5'-phosphoribosyl-N-formyl glycineamidinehmdb
N-(2-amino-2-Iminoethyl)-N-(5-O-ONO-b-D-ribofuranosyl)-formamideHMDB
N-(2-amino-2-Iminoethyl)-N-(5-O-ONO-beta-delta-ribofuranosyl)-formamideHMDB
N-(2-amino-2-iminoethyl)-N-(5-O-phosphono-b-D-ribofuranosyl)-Formamidehmdb
N-(2-amino-2-iminoethyl)-N-(5-O-phosphono-beta-delta-ribofuranosyl)-Formamidehmdb
Predicted Properties
PropertyValueSource
Water Solubility8.65 g/LALOGPS
logP-2.6ALOGPS
logP-4.1ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)1.23ChemAxon
pKa (Strongest Basic)7.38ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area181.43 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity72.72 m³·mol⁻¹ChemAxon
Polarizability25.96 ųChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC8H16N3O8P
IUPAC name{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoethanimidamido)oxolan-2-yl]methoxy}phosphonic acid
InChI IdentifierInChI=1S/C8H16N3O8P/c9-5(1-10-3-12)11-8-7(14)6(13)4(19-8)2-18-20(15,16)17/h3-4,6-8,13-14H,1-2H2,(H2,9,11)(H,10,12)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
InChI KeyPMCOGCVKOAOZQM-XVFCMESISA-N
Isomeric SMILESO[C@H]1[C@@H](O)[C@H](NC(=N)CNC=O)O[C@@H]1COP(O)(O)=O
Average Molecular Weight313.2017
Monoisotopic Molecular Weight313.067501015
Classification
Description belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentPentose phosphates
Alternative Parents
Substituents
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • Monosaccharide phosphate
  • Monoalkyl phosphate
  • Organic phosphoric acid derivative
  • Alkyl phosphate
  • Phosphoric acid ester
  • Tetrahydrofuran
  • 1,2-diol
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Amidine
  • Carboxylic acid amidine
  • Carboxylic acid derivative
  • Oxacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboximidamide
  • Organic oxide
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Carbonyl group
  • Organonitrogen compound
  • Alcohol
  • Organopnictogen compound
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Source:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9860000000-053d3def2f2031f6f985JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positivesplash10-03fv-9626200000-4af28dfe3b4dc1c71a02JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-114i-9732000000-7a823a35c9828d22327cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0kmi-9300000000-2f206fd034f1fb2795fcJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0kmr-9400000000-a855d87bf0ed7c457172JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0w2c-6903000000-621c45a21326a0c06addJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9300000000-0415faa4289f87539ce2JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-73ad9c3af703650a3eedJSpectraViewer
ChemSpider ID7830994
ChEMBL IDNot Available
KEGG Compound IDC04640
Pubchem Compound ID440417
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB00999
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
Trifunctional purine biosynthetic protein adenosine-3GARTP22102
Phosphoribosylformylglycinamidine synthasePFASO15067
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference