1.0 2011-09-21 00:35:20 UTC 2019-11-26 03:21:10 UTC FDB023822 o-Tyrosine o-Tyrosine is a normal human metabolite. Its presence is possible due to the hydroxylation of l-phenylalanine by hydroxyl radical (*OH), and is proposed as an hydroxy radical biomarker of oxidative damage to proteins. o-Tyrosine might also be included in the diet and absorbed. It has been associated with disease such as Kwashiorkor, a severe form of protein-energy malnutrition. However, many publications mention that the results are inconclusive, and o-tyrosine is not selectively altered by antioxidant intervention, exercise training or age. (PMID: 14670743, 10969271, 9887186) [HMDB] 2-hydroxy-DL-Phenylalanine 2-hydroxy-Phenylalanine 2-Hydroxyphenylalanine 2-Tyrosine 3-(o-hydroxyphenyl)DL-Alanine DL- O-tyrosine DL-3-(o-Hydroxyphenyl)alanine DL-o-tyrosine Ortho-tyrosine C9H11NO3 181.1885 181.073893223 2-amino-3-(2-hydroxyphenyl)propanoic acid 2-tyrosine 2370-61-8 NC(CC1=CC=CC=C1O)C(O)=O InChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13) WRFPVMFCRNYQNR-UHFFFAOYSA-N belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Phenylalanine and derivatives Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aromatic homomonocyclic compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alpha amino acids Amino acids Amphetamines and derivatives Aralkylamines Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Phenylpropanoic acids 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 3-phenylpropanoic-acid Alpha-amino acid Amine Amino acid Amphetamine or derivatives Aralkylamine Aromatic homomonocyclic compound Benzenoid Carbonyl group Carboxylic acid Hydrocarbon derivative Monocarboxylic acid or derivatives Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Phenol Phenylalanine or derivatives Primary aliphatic amine Primary amine an amino acid derivative Solid logp -2.34 ALOGPS logs -1.51 ALOGPS solubility 5.57e+00 g/l ALOGPS logp -1.5 ChemAxon pka_strongest_acidic 2.01 ChemAxon pka_strongest_basic 8.88 ChemAxon iupac 2-amino-3-(2-hydroxyphenyl)propanoic acid ChemAxon average_mass 181.1885 ChemAxon mono_mass 181.073893223 ChemAxon smiles NC(CC1=CC=CC=C1O)C(O)=O ChemAxon formula C9H11NO3 ChemAxon inchi InChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13) ChemAxon inchikey WRFPVMFCRNYQNR-UHFFFAOYSA-N ChemAxon polar_surface_area 83.55 ChemAxon refractivity 47.1 ChemAxon polarizability 17.76 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 13709 Specdb::CMs 38950 Specdb::CMs 127933 Specdb::CMs 135828 Specdb::CMs 143562 Specdb::CMs 831120 Specdb::CMs 831121 Specdb::CMs 831122 Specdb::CMs 831123 Specdb::CMs 831124 Specdb::CMs 831125 Specdb::CMs 831126 Specdb::CMs 831127 Specdb::CMs 831128 Specdb::CMs 831129 Specdb::CMs 831130 Specdb::CMs 831131 Specdb::CMs 831132 Specdb::NmrTwoD 1969 Specdb::NmrOneD 2035 Specdb::NmrOneD 61632 Specdb::NmrOneD 61633 Specdb::NmrOneD 61634 Specdb::NmrOneD 61635 Specdb::NmrOneD 61636 Specdb::NmrOneD 61637 Specdb::NmrOneD 61638 Specdb::NmrOneD 61639 Specdb::NmrOneD 61640 Specdb::NmrOneD 61641 Specdb::NmrOneD 61642 Specdb::NmrOneD 61643 Specdb::NmrOneD 61644 Specdb::NmrOneD 61645 Specdb::NmrOneD 61646 Specdb::NmrOneD 61647 Specdb::NmrOneD 61648 Specdb::NmrOneD 61649 Specdb::NmrOneD 61650 Specdb::NmrOneD 61651 Specdb::NmrOneD 166565 Specdb::MsIr 2359 Specdb::MsIr 2360 Specdb::MsIr 2361 Specdb::MsMs 2466 Specdb::MsMs 2467 Specdb::MsMs 2468 Specdb::MsMs 296221 Specdb::MsMs 296222 Specdb::MsMs 296223 Specdb::MsMs 337465 Specdb::MsMs 337466 Specdb::MsMs 337467 Specdb::MsMs 2391610 Specdb::MsMs 2391611 Specdb::MsMs 2391612 Specdb::MsMs 2570597 Specdb::MsMs 2570598 Specdb::MsMs 2570599 HMDB06050 #<Reference:0x000055ce31878ae8> #<Reference:0x000055ce31878930> #<Reference:0x000055ce31878778> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823