| Health Effects / Bioactivities | | Descriptor | ID | Definition | Reference |
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| Anti-alopecic | 52217 | An agent that promotes hair growth and prevents hair loss, commonly used to treat alopecia and other hair-related disorders, by inhibiting dihydrotestosterone (DHT) and stimulating hair follicle growth. | DUKE | | Anti-atherosclerotic | 38070 | An agent that prevents or slows the formation of atherosclerosis, a condition characterized by plaque buildup in arteries. It reduces inflammation, improves lipid profiles, and inhibits platelet aggregation, commonly used to manage cardiovascular diseases, such as coronary artery disease, and prevent heart attacks and strokes. | DUKE | | Anti bacterial | 33282 | An agent that inhibits the growth of or destroys bacteria, playing a crucial role in preventing and treating infections. Therapeutically, it is used to combat bacterial infections, with key medical applications including treating pneumonia, tuberculosis, and skin infections, as well as preventing surgical site infections and sepsis. | DUKE | | Anti CVI | | An antibiotic that counteracts colicin V, a protein involved in E. coli immunity, used to combat bacterial infections and potentially applied in treating E. coli-related diseases. | DUKE | | Anti-diabetic | 52217 | An agent that regulates blood sugar levels, enhancing insulin sensitivity or secretion. Therapeutically, it's used to manage diabetes, reducing symptoms and complications, and commonly prescribed to treat type 1 and 2 diabetes, as well as gestational diabetes. | DUKE | | Anti-edemic | | An agent that relieves or prevents edema, reducing abnormal fluid accumulation in tissues or the circulatory system, commonly used to treat conditions such as swelling, inflammation, and water retention. | DUKE | | Anti histaminic | 37956 | An agent that blocks histamine receptors, reducing allergic symptoms. Therapeutically, it alleviates itching, sneezing, and runny nose, commonly used in managing allergies, itching, and hives, as well as treating conditions like anaphylaxis and allergic rhinitis. | DUKE | | Anti-ischemic | 52217 | An agent that reduces or prevents tissue damage from inadequate blood flow, commonly used to manage angina, heart attacks, and strokes by improving oxygen delivery and reducing cardiac workload. | DUKE | | Anti-oxidant | 22586 | An agent that neutralizes free radicals, reducing oxidative stress and cell damage. Its biological role involves protecting cells from harm, and it has therapeutic applications in managing chronic diseases, such as cancer, diabetes, and neurodegenerative disorders, with key medical uses including anti-aging, anti-inflammatory, and cardio protective effects. | DUKE | | Anti periodontal | | An agent that prevents or treats gum disease, reducing inflammation and infection in the gums and supporting tissues of the teeth, commonly used in managing periodontitis and promoting oral health. | DUKE | | Anti-plaque | | An agent that removes or prevents the formation of dental plaque, a biofilm of bacteria, to prevent tooth decay and gum disease, commonly used in oral care products and therapeutic applications for periodontal health. | DUKE | | Anti proliferant | | An agent that prevents or inhibits cell growth and division, used therapeutically to treat cancer, manage tumor growth, and prevent restenosis after angioplasty, reducing abnormal cell proliferation. | DUKE | | Anti retinopathic | 52217 | An agent that prevents or treats retinopathy, a disease damaging the retina. It plays a biological role in reducing oxidative stress and inflammation, and has therapeutic applications in managing diabetic retinopathy and other retinal disorders, with key medical uses including preserving vision and preventing blindness. | DUKE | | Anti septic | 33281 | An agent that prevents or reduces the growth of microorganisms, such as bacteria, fungi, or viruses, to promote wound healing and prevent infection. Therapeutically, anti septics are used to treat minor cuts, scrapes, and burns, and are commonly applied topically to reduce the risk of infection and promote tissue repair. Key medical uses include wound care, surgical site preparation, and skin infection management. | DUKE | | Anti-stroke | 52217 | An agent that prevents or reduces the severity of stroke, typically by inhibiting blood clot formation or improving cerebral blood flow, commonly used in managing cardiovascular diseases, preventing stroke recurrence, and reducing stroke-related brain damage. | DUKE | | Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE | | Anti-viral | 22587 | An agent that inhibits the replication of viruses, playing a crucial role in preventing and treating viral infections. Therapeutically, anti-virals are used to manage diseases such as HIV, herpes, and influenza, reducing symptoms and slowing disease progression. Key medical uses include treating viral hepatitis, respiratory syncytial virus, and COVID-19. | DUKE | | Beta-glucuronidase inhibitor | 23924 | An agent that blocks the activity of beta-glucuronidase, an enzyme that breaks down glucuronides. It reduces the toxicity of certain drugs and is used to manage conditions like cancer, inflammatory bowel disease, and irinotecan-induced diarrhea, improving treatment outcomes and reducing side effects. | DUKE | | Capillariprotective | | An agent that protects and strengthens capillaries, alleviating conditions such as fragility and permeability. Therapeutically, it helps manage disorders like hemorrhoids and varicose veins, and has applications in reducing inflammation and improving microcirculation, commonly used in vascular health and wound healing. | DUKE | | Cardioprotective | 38070 | An agent that protects the heart from damage, reducing the risk of cardiovascular disease. It plays a biological role in mitigating cardiac stress and injury, with therapeutic applications in preventing heart attacks, strokes, and arrhythmias, and key medical uses in treating hypertension, heart failure, and coronary artery disease. | DUKE | | Collagenase inhibitor | 23924 | An agent that blocks the activity of collagenase, an enzyme that breaks down collagen. It reduces tissue damage and inflammation, commonly used in managing conditions such as osteoarthritis, tendonitis, and wound healing. | DUKE | | Collagenic | | An agent that stimulates collagen production, the primary protein in connective tissue, promoting tissue repair and regeneration. It has therapeutic applications in wound healing, orthopedics, and dermatology, with key medical uses including skin rejuvenation, joint health, and bone fracture repair. | DUKE | | Deodorant | | A substance that removes or conceals unpleasant smells, especially bodily odors, playing a hygienic role in reducing sweat-induced bacteria growth, with therapeutic applications in managing body odor disorders, and key medical uses in treating hyperhidrosis and bromhidrosis. | DUKE | | Elastase inhibitor | 23924 | An agent that blocks the activity of elastase, an enzyme that breaks down elastin, reducing tissue damage and inflammation. Therapeutically, it's used to manage conditions like chronic obstructive pulmonary disease (COPD), cystic fibrosis, and emphysema, protecting lung tissue and improving respiratory function. | DUKE | | Gram(+)icide | 33282 | An agent that targets and kills Gram-positive bacteria, playing a crucial role in treating bacterial infections. Therapeutically, it is used to combat infections caused by Gram-positive microorganisms, with key medical applications including treating skin infections, pneumonia, and sepsis. | DUKE | | Gram(-)icide | 33282 | An agent that kills Gram-negative bacteria, playing a crucial role in treating infections. Therapeutically, it is used to combat bacterial infections, particularly those resistant to other antibiotics. Key medical uses include treating sepsis, pneumonia, and urinary tract infections caused by Gram-negative bacteria. | DUKE | | Hepatoprotective | 62868 | An agent that protects the liver from damage, promoting liver health and function. It plays a biological role in reducing oxidative stress and inflammation, and has therapeutic applications in managing liver diseases, such as hepatitis and cirrhosis, and key medical uses in treating drug-induced liver injury and toxicities. | DUKE | | Hyaluronidase inhibitor | 23924 | An agent that blocks the activity of hyaluronidase, an enzyme that breaks down hyaluronic acid. This inhibition helps maintain hyaluronic acid levels, reducing inflammation and improving tissue hydration, with therapeutic applications in ophthalmology, dermatology, and oncology, and key medical uses in treating dry eye, wrinkles, and certain cancers. | DUKE | | Hypoglycemic | 35526 | An agent that lowers blood glucose levels, playing a crucial role in glucose metabolism. Therapeutically, it is used to manage diabetes and insulin resistance, with key medical applications in treating type 1 and 2 diabetes, and preventing diabetic complications. | DUKE | | Ornithine-decarboxylase inhibitor | 23924 | An agent that blocks the activity of ornithine decarboxylase, an enzyme involved in cell growth and proliferation. It reduces polyamine synthesis, inhibiting tumor growth and proliferation. Therapeutically, it is used to treat cancer, particularly in combination with other therapies, and has potential applications in managing parasitic infections and skin disorders. | DUKE | | Tyrosine kinase inhibitor | | An agent that blocks the enzymatic activity of tyrosine kinases, enzymes responsible for the activation of many proteins involved in signal transduction pathways regulating cell growth and survival. Therapeutically, tyrosine kinase inhibitors are widely used in the treatment of various cancers and proliferative diseases, by halting aberrant signaling that drives tumor progression and pathological tissue remodeling. | DUKE | | Vasodilator | 35620 | An agent that widens blood vessels, reducing blood pressure and increasing blood flow. It plays a biological role in regulating cardiovascular function. Therapeutically, vasodilators are used to treat conditions such as hypertension, angina, and heart failure, improving oxygen delivery and reducing cardiac workload. | DUKE | | Vasorelaxant | | An agent that promotes vasorelaxation, reducing vascular tension and blood pressure. It plays a biological role in regulating blood flow and is therapeutically used to treat hypertension, angina, and heart failure, improving cardiovascular health. | DUKE |
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