1.0 2010-04-08 22:07:27 UTC 2025-11-18 23:03:57 UTC FDB007124 N-Demethyldiazepam N-demethyldiazepam, also known as nordiazepam or calmday, is a member of the class of compounds known as 1,4-benzodiazepines. 1,4-benzodiazepines are organic compounds containing a benzene ring fused to a 1,4-azepine. N-demethyldiazepam is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). N-demethyldiazepam can be found in common wheat, corn, and potato, which makes N-demethyldiazepam a potential biomarker for the consumption of these food products. N-demethyldiazepam can be found primarily in blood and urine, as well as in human kidney and liver tissues. N-demethyldiazepam is a non-carcinogenic (not listed by IARC) potentially toxic compound. General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended (T3DB). 1-Demethyldiazepam 2H-1,4-Benzodiazepin-2-one, 1, 3-dihydro-7-chloro-5-phenyl- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl- 5-phenyl-7-chloro-1,4-benzodiazepin-2-one 7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on 7-Chloro-1, 3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Calmday Chlordesmethyldiazepam Clorazepate (break down) Dealkylprazepam Demadar Demethyldiazepam Deoxydemoxepam Desalkylprazepam Desmethyldiazepam DMDZ Lomax Madar N-demethyldiazepam N-deoxydemoxapam N-deoxydemoxepam N-desalkylhalazepam N-descyclopropylmethyl-prazepam N-descyclopropylmethylprazepam N-desmethyldiazepam N-destrifluoroethylhalazepam N1-Desmethyldiazepam NDD NDZ Nordaz Nordazepam Nordazepam [inn] Nordazepamum Nordiazepam Norprazepam Praxadium Sopax Stilny Vegesan C15H11ClN2O 270.714 270.055990691 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one nordiazepam 1088-11-5 ClC1=CC=C2NC(=O)CN=C(C3=CC=CC=C3)C2=C1 InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19) AKPLHCDWDRPJGD-UHFFFAOYSA-N belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine. 1,4-benzodiazepines Organic compounds Organoheterocyclic compounds Benzodiazepines 1,4-benzodiazepines Aromatic heteropolycyclic compounds Aryl chlorides Azacyclic compounds Benzene and substituted derivatives Cyclic carboximidic acids Hydrocarbon derivatives Ketimines Organochlorides Organooxygen compounds Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds 1,4-benzodiazepine Aromatic heteropolycyclic compound Aryl chloride Aryl halide Azacycle Benzenoid Cyclic carboximidic acid Hydrocarbon derivative Imine Ketimine Monocyclic benzene moiety Organic 1,3-dipolar compound Organic nitrogen compound Organic oxygen compound Organochloride Organohalogen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound 1,4-benzodiazepinone organochlorine compound logp 2.79 ALOGPS logs -4.09 ALOGPS solubility 2.19e-02 g/l ALOGPS melting_point 216.5 oC logp 3.21 ChemAxon pka_strongest_acidic 12.3 ChemAxon pka_strongest_basic 2.85 ChemAxon iupac 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ChemAxon average_mass 270.714 ChemAxon mono_mass 270.055990691 ChemAxon smiles ClC1=CC=C2NC(=O)CN=C(C3=CC=CC=C3)C2=C1 ChemAxon formula C15H11ClN2O ChemAxon inchi InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19) ChemAxon inchikey AKPLHCDWDRPJGD-UHFFFAOYSA-N ChemAxon polar_surface_area 41.46 ChemAxon refractivity 76.7 ChemAxon polarizability 27.41 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 1372 Specdb::CMs 34607 Specdb::CMs 165074 Specdb::MsMs 47853 Specdb::MsMs 47854 Specdb::MsMs 47855 Specdb::MsMs 121443 Specdb::MsMs 121444 Specdb::MsMs 121445 Specdb::MsMs 436715 Specdb::MsMs 436716 Specdb::MsMs 436717 Specdb::MsMs 436718 Specdb::MsMs 436719 Specdb::MsMs 436720 Specdb::MsMs 436721 Specdb::MsMs 436722 Specdb::MsMs 441156 Specdb::MsMs 441157 Specdb::MsMs 441158 Specdb::MsMs 441159 Specdb::MsMs 444446 Specdb::MsMs 444447 Specdb::MsMs 444448 Specdb::MsMs 444449 Specdb::MsMs 444450 Specdb::MsMs 444451 Specdb::MsMs 444452 HMDB0060538 Common wheat Type 1 specific Triticum aestivum 4565 Corn Type 1 specific Zea mays 4577 Potato Type 1 specific Solanum tuberosum 4113 Anxiolytic 698 Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. Sedative 1311 A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.