Record Information |
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Version | 1.0 |
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Creation date | 2010-04-08 22:08:17 UTC |
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Update date | 2019-11-26 03:03:19 UTC |
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Primary ID | FDB008857 |
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Secondary Accession Numbers | Not Available |
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Chemical Information |
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FooDB Name | 3-(3,4-Dihydroxyphenyl)propanoic acid |
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Description | 3,4-Dihydroxyhydrocinnamic acid (or Dihydrocaffeic acid, DHCA) is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties. DHCA has been detected in human plasma following coffee ingestion (PMID 15607645), and is increased with some dietary sources, such as after ingestion of phenolic constituents of artichoke leaf extract. (PMID 15693705) Polyphenol-rich foods such as vegetables and fruits have been shown to significantly improve platelet function in ex vivo studies in humans. (PMID 16038718) Its antioxidant activity has been tested to reduce ferric iron in the ferric reducing antioxidant power (FRAP) assay, and it has been suggested that its catechol structure convey the antioxidant effect in plasma and in erythrocytes. (PMID 11768243) [HMDB]. 3-(3,4-Dihydroxyphenyl)propanoic acid is found in red beetroot, common beet, and olive. |
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CAS Number | 1078-61-1 |
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Structure | |
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Synonyms | Synonym | Source |
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3,4-Dihydroxy-beta-phenylpropionic acid | ChEBI | 3,4-Dihydroxybenzenepropionic acid | ChEBI | 3,4-Dihydroxydihydrocinnamic acid | ChEBI | 3,4-Dihydroxyphenylpropionic acid | ChEBI | 3-(3,4-Dihydroxyphenyl)propanoate | Kegg | 3,4-Dihydroxy-b-phenylpropionate | Generator | 3,4-Dihydroxy-b-phenylpropionic acid | Generator | 3,4-Dihydroxy-beta-phenylpropionate | Generator | 3,4-Dihydroxy-β-phenylpropionate | Generator | 3,4-Dihydroxy-β-phenylpropionic acid | Generator | 3,4-Dihydroxybenzenepropanoate | Generator | 3,4-Dihydroxybenzenepropionate | Generator | 3,4-Dihydroxydihydrocinnamate | Generator | 3,4-Dihydroxyphenylpropionate | Generator | 3-(3,4-Dihydroxyphenyl)propionate | Generator | Dihydrocaffeate | Generator | Hydrocaffeate | Generator | 3-(3,4-Dihydroxyphenyl)propanoic acid | Generator | 3,4-Dihydroxyhydrocinnamate | Generator | 3,4-Dihydroxy-(6ci,7ci,8ci)hydrocinnamate | HMDB | 3,4-Dihydroxy-(6ci,7ci,8ci)hydrocinnamic acid | HMDB | 3,4-Dihydroxyphenylpropionic acid, potassium salt | HMDB | DHC | HMDB | 3,4-Dihydroxyhydrocinnamic acid | HMDB | 3-(3',4'-Dihydroxyphenyl)propanoic acid | HMDB | 3-(3,4-Dihydroxyphenyl)propionic acid | ChEBI | 3,4-Dihydroxybenzenepropanoic acid | ChEBI | 3,4-Dihydroxybenzenepropanoic acid, 9CI | db_source | 3,4-Dihydroxyhydrocinnamic acid, 8CI | db_source | Dihydrocaffeic acid | ChEBI | Hydrocaffeic acid | db_source |
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Predicted Properties | |
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Chemical Formula | C9H10O4 |
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IUPAC name | 3-(3,4-dihydroxyphenyl)propanoic acid |
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InChI Identifier | InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13) |
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InChI Key | DZAUWHJDUNRCTF-UHFFFAOYSA-N |
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Isomeric SMILES | OC(=O)CCC1=CC=C(O)C(O)=C1 |
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Average Molecular Weight | 182.1733 |
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Monoisotopic Molecular Weight | 182.057908808 |
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Classification |
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Description | Belongs to the class of organic compounds known as phenylpropanoic acids. Phenylpropanoic acids are compounds with a structure containing a benzene ring conjugated to a propanoic acid. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Phenylpropanoic acids |
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Sub Class | Not Available |
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Direct Parent | Phenylpropanoic acids |
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Alternative Parents | |
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Substituents | - 3-phenylpropanoic-acid
- Catechol
- 1-hydroxy-4-unsubstituted benzenoid
- 1-hydroxy-2-unsubstituted benzenoid
- Phenol
- Monocyclic benzene moiety
- Benzenoid
- Carboxylic acid derivative
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Organic oxide
- Organic oxygen compound
- Carbonyl group
- Organooxygen compound
- Hydrocarbon derivative
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Ontology |
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Disposition | Route of exposure: Source: Biological location: |
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Foods | Cocoa and cocoa products Grains: Nuts and legumes: Fruits and vegetables: Fats and oils: Beverages: |
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Physico-Chemical Properties - Experimental |
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Physico-Chemical Properties - Experimental | Property | Value | Reference |
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Physical state | Solid | |
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Physical Description | Not Available | |
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Mass Composition | C 59.34%; H 5.53%; O 35.13% | DFC |
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Melting Point | Not Available | |
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Boiling Point | Not Available | |
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Experimental Water Solubility | Not Available | |
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Experimental logP | Not Available | |
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Experimental pKa | Not Available | |
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Isoelectric point | Not Available | |
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Charge | Not Available | |
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Optical Rotation | Not Available | |
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Spectroscopic UV Data | Not Available | |
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Density | Not Available | |
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Refractive Index | Not Available | |
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Spectra |
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Spectra | |
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EI-MS/GC-MS | Type | Description | Splash Key | View |
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GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, 3 TMS, GC-MS Spectrum | splash10-004i-0921000000-69e0a3dba4177ea9ada1 | Spectrum | GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, non-derivatized, GC-MS Spectrum | splash10-004i-0921000000-69e0a3dba4177ea9ada1 | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | splash10-00dr-1900000000-8f0742a594d0db727f11 | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positive | splash10-00ur-8069000000-113cede8ffd5381ab0cb | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | 3-(3,4-Dihydroxyphenyl)propanoic acid, TBDMS_3_1, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum |
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MS/MS | Type | Description | Splash Key | View |
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MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated) | splash10-000f-0900000000-1dc54a535903f260b0b5 | 2012-07-24 | View Spectrum | MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated) | splash10-00kf-9100000000-74f0336af78b5918b04c | 2012-07-24 | View Spectrum | MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated) | splash10-014i-9000000000-1d433aef86dca3b39c53 | 2012-07-24 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative | splash10-001i-0900000000-4589cb5cf740dc1eefe5 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative | splash10-000i-1900000000-bc36f01d18b6b4248472 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative | splash10-0a4i-6900000000-e57c83d231268edc054f | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative | splash10-0a4i-9700000000-53a68c60a48fdb8e01e6 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative | splash10-0a4l-9600000000-a48102a57ed6eae9a8bf | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-001i-0900000000-4589cb5cf740dc1eefe5 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-000i-1900000000-8a038a280dd3f89e7884 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-0a4i-6900000000-2b1f1c909f6abe0d4256 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-0a4i-9700000000-53a68c60a48fdb8e01e6 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-0a4l-9600000000-a48102a57ed6eae9a8bf | 2017-09-14 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-014i-0900000000-2cfd60989d2ef67b4c9b | 2015-04-24 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00kr-0900000000-fbaa85a997efb64c857a | 2015-04-24 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0l4i-9700000000-f7bdc64c528a71696640 | 2015-04-24 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001i-0900000000-867d0860de62a4c828f0 | 2015-04-25 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-01qi-1900000000-7a274d4ecad972f6ce6f | 2015-04-25 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4l-9700000000-110fe57d501253fffb52 | 2015-04-25 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001i-3900000000-53d05d44c9f04241cf04 | 2021-09-22 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-000i-2900000000-6e00dd669916da3428f4 | 2021-09-22 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-052o-7900000000-2bdbc4d0abb4a38f24a2 | 2021-09-22 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00ri-0900000000-b16be98ef6ecf4a3e14e | 2021-09-22 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00ds-3900000000-d4579b1d6243d67dbb8d | 2021-09-22 | View Spectrum | Predicted MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0uyj-9300000000-ead994336f6a97bcf6ee | 2021-09-22 | View Spectrum |
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NMR | Type | Description | | View |
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1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, experimental) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 100 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 200 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 300 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 400 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 600 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 700 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 800 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, D2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 900 MHz, D2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, D2O, predicted) | | Spectrum | 2D NMR | [1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental) | | Spectrum |
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External Links |
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ChemSpider ID | 308986 |
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ChEMBL ID | CHEMBL136927 |
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KEGG Compound ID | C10447 |
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Pubchem Compound ID | 348154 |
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Pubchem Substance ID | Not Available |
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ChEBI ID | Not Available |
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Phenol-Explorer ID | 579 |
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DrugBank ID | Not Available |
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HMDB ID | HMDB00423 |
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CRC / DFC (Dictionary of Food Compounds) ID | DZN32-V:DZN32-V |
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EAFUS ID | Not Available |
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Dr. Duke ID | HYDROCAFFEIC-ACID|DIHYDROCAFFEIC-ACID |
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BIGG ID | Not Available |
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KNApSAcK ID | C00002735 |
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HET ID | Not Available |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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Flavornet ID | Not Available |
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GoodScent ID | Not Available |
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SuperScent ID | Not Available |
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Wikipedia ID | Not Available |
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Phenol-Explorer Metabolite ID | 579 |
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Duplicate IDS | Not Available |
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Old DFC IDS | Not Available |
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Associated Foods |
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Food | Content Range | Average | Reference |
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Food | | | Reference |
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Biological Effects and Interactions |
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Health Effects / Bioactivities | Descriptor | ID | Definition | Reference |
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antioxidant | 22586 | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324. | CHEBI |
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Enzymes | Not Available |
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Pathways | Not Available |
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Metabolism | Not Available |
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Biosynthesis | Not Available |
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Organoleptic Properties |
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Flavours | Not Available |
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Files |
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MSDS | show |
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References |
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Synthesis Reference | Not Available |
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General Reference | Not Available |
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Content Reference | — Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181. — Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070. — Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
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